Open Access

Clinical significance and effect of Sam68 expression in gastric cancer

  • Authors:
    • Jinzhang Xiao
    • Qiuhong Wang
    • Qichang Yang
    • Hua Wang
    • Fulin Qiang
    • Song He
    • Jin Cai
    • Lei Yang
    • Yingying Wang
  • View Affiliations

  • Published online on: February 2, 2018     https://doi.org/10.3892/ol.2018.7930
  • Pages: 4745-4752
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer is one of the most common types of malignancy worldwide. However, the molecular mechanisms of cancer development remain unclear. Src‑associated in mitosis of 68 kDa (Sam68) is involved in cell proliferation, transformation, tumorigenesis and metastasis in several types of cancer. The present study aimed to assess the expression and function of Sam68 in human gastric cancer. Western blot analysis and immunohistochemistry indicated that Sam68 expression was increased in tumor samples and the levels were associated with the grade of malignancy. High Sam68 expression was associated with the poor prognosis of patients with gastric cancer. In vitro, following knockdown of Sam68 by transfection of gastric cancer cells with small interfering RNA, the cell viability, cell cycle progress, migration and invasion were decreased. The results of the present study revealed that Sam68 may be a novel prognostic factor for, and is associated with cell growth, migration and invasion in, gastric cancer.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S. ... Wang, Y. (2018). Clinical significance and effect of Sam68 expression in gastric cancer. Oncology Letters, 15, 4745-4752. https://doi.org/10.3892/ol.2018.7930
MLA
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S., Cai, J., Yang, L., Wang, Y."Clinical significance and effect of Sam68 expression in gastric cancer". Oncology Letters 15.4 (2018): 4745-4752.
Chicago
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S., Cai, J., Yang, L., Wang, Y."Clinical significance and effect of Sam68 expression in gastric cancer". Oncology Letters 15, no. 4 (2018): 4745-4752. https://doi.org/10.3892/ol.2018.7930