Open Access

MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma

  • Authors:
    • Junsheng Lian
    • Yujie Li
    • Min Yu
  • View Affiliations

  • Published online on: November 1, 2018     https://doi.org/10.3892/ol.2018.9650
  • Pages: 1172-1176
  • Copyright: © Lian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study investigated whether microRNA‑183 and microRNA‑141 in nasopharyngeal carcinoma (NPC) lesions are potential risk factors for poor prognosis. A total of 317 NPC patients admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2010 to March 2015 were included. Reverse transcription‑quantitative PCR (RT‑qPCR) was used to detect the expression of microRNA‑183 and microRNA‑141 in lesions and adjacent tissues, and the relationship between the microRNA‑183 and microRNA‑141 expression levels and prognosis was analyzed. The expression levels of microRNA‑183 and microRNA‑141 in lesions were significantly higher than those in adjacent tissues (p<0.05). Patients with distant metastasis had significantly higher expression levels of microRNA‑183 and microRNA‑141 than patients without distant metastasis (p<0.01). Patients with disease‑free survival (DFS) <3 years showed significantly higher expression levels of microRNA‑183 and microRNA‑141 than those with DFS ≥3 years (p<0.01). NPC patients with high expression levels of microRNA‑183 and microRNA‑141 showed poor prognosis. MicroRNA‑183 and microRNA‑141 may play an important role in the distant metastasis of NPC, and have a great impact on prognosis.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lian J, Li Y and Yu M: MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma. Oncol Lett 17: 1172-1176, 2019
APA
Lian, J., Li, Y., & Yu, M. (2019). MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma. Oncology Letters, 17, 1172-1176. https://doi.org/10.3892/ol.2018.9650
MLA
Lian, J., Li, Y., Yu, M."MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 17.1 (2019): 1172-1176.
Chicago
Lian, J., Li, Y., Yu, M."MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 17, no. 1 (2019): 1172-1176. https://doi.org/10.3892/ol.2018.9650