Comprehensive bioinformatics analysis of lncRNAs in gastric cancer

  • Authors:
    • Dongdong Qi
    • Qiang Wang
    • Meiqing Wu
    • Xiong Zhang
  • View Affiliations

  • Published online on: November 15, 2018     https://doi.org/10.3892/ol.2018.9707
  • Pages: 1279-1291
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Abstract

Long non‑coding RNAs (lncRNAs) have been generally considered to serve important roles in various types of cancer, including gastric cancer. However, a comprehensive understanding of lncRNAs in gastric cancer requires further study. The present study performed an in‑depth study revealed 50 differently expressed lncRNAs. The changed cellular pathways and biological process in gastric cancer were determined. To further confirm the functions of the differently expressed lncRNAs, co‑expression networks were constructed between the lncRNAs and mRNA; this lead to the identification of 6 modules, which participated in various cellular pathways. In addition, 2 lncRNAs were identified which were associated with clinical outcome. The biological analysis and experimental evidence suggested that LINC00982 inhibited, while LL22NC03‑N14H11.1 promoted the proliferation of gastric cancer cells. These lncRNAs may be considered as potential prognostic factor in gastric cancer.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qi D, Wang Q, Wu M and Zhang X: Comprehensive bioinformatics analysis of lncRNAs in gastric cancer. Oncol Lett 17: 1279-1291, 2019
APA
Qi, D., Wang, Q., Wu, M., & Zhang, X. (2019). Comprehensive bioinformatics analysis of lncRNAs in gastric cancer. Oncology Letters, 17, 1279-1291. https://doi.org/10.3892/ol.2018.9707
MLA
Qi, D., Wang, Q., Wu, M., Zhang, X."Comprehensive bioinformatics analysis of lncRNAs in gastric cancer". Oncology Letters 17.1 (2019): 1279-1291.
Chicago
Qi, D., Wang, Q., Wu, M., Zhang, X."Comprehensive bioinformatics analysis of lncRNAs in gastric cancer". Oncology Letters 17, no. 1 (2019): 1279-1291. https://doi.org/10.3892/ol.2018.9707