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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2011 Volume 25 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells

  • Authors:
    • Cinzia Puppin
    • Nadia Passon
    • Alessandra Franzoni
    • Diego Russo
    • Giuseppe Damante

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, Udine, Italy, Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
  • Pages: 393-397
    |
    Published online on: December 7, 2010
       https://doi.org/10.3892/or.2010.1075
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Abstract

Prohibitin (PHB) is a ubiquitous protein with a number of different molecular functions. PHB is involved in tumorigenesis by exerting either a permissive or blocking action on tumor growth, depending on the cell context. In the present study, we investigated the effects of the histone deacetylase inhibitors (HDACis), trichostatin A (TSA) and sodium butyrate (NaB), on PHB expression in the thyroid tumor cell lines, TPC-1 and FRO. Both TSA and NaB increased PHB mRNA levels. Transfection experiments showed that the overexpression of HDAC1 or 2, but not 3, inhibited PHB promoter activity. The effects of TSA and NaB on the two major PHB mRNA splicing isoforms, were also investigated. Both TSA and NaB decreased the mRNA levels of the shorter isoform, but increased those of the longer isoform. Only the latter isoform contains a 3'UTR, which has been reported to exert a growth suppressive action. Thus, our data demonstrate that HDACis control both PHB transcription and alternative splicing. The effect of HDACis on PHB alternative splicing was not due to the modification of the expression of the ASF/SF2 splicing factor.

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Copy and paste a formatted citation
Spandidos Publications style
Puppin C, Passon N, Franzoni A, Russo D and Damante G: Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. Oncol Rep 25: 393-397, 2011.
APA
Puppin, C., Passon, N., Franzoni, A., Russo, D., & Damante, G. (2011). Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. Oncology Reports, 25, 393-397. https://doi.org/10.3892/or.2010.1075
MLA
Puppin, C., Passon, N., Franzoni, A., Russo, D., Damante, G."Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells". Oncology Reports 25.2 (2011): 393-397.
Chicago
Puppin, C., Passon, N., Franzoni, A., Russo, D., Damante, G."Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells". Oncology Reports 25, no. 2 (2011): 393-397. https://doi.org/10.3892/or.2010.1075
Copy and paste a formatted citation
x
Spandidos Publications style
Puppin C, Passon N, Franzoni A, Russo D and Damante G: Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. Oncol Rep 25: 393-397, 2011.
APA
Puppin, C., Passon, N., Franzoni, A., Russo, D., & Damante, G. (2011). Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. Oncology Reports, 25, 393-397. https://doi.org/10.3892/or.2010.1075
MLA
Puppin, C., Passon, N., Franzoni, A., Russo, D., Damante, G."Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells". Oncology Reports 25.2 (2011): 393-397.
Chicago
Puppin, C., Passon, N., Franzoni, A., Russo, D., Damante, G."Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells". Oncology Reports 25, no. 2 (2011): 393-397. https://doi.org/10.3892/or.2010.1075
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