Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review)

Organista-Nava,Jorge; Gómez-Gómez,Yazmín; Illades-Aguiar,Berenice; Leyva-Vázquez,Marco  Antonio

doi:10.3892/or.2016.4948

Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review)

Authors:
- Jorge Organista-Nava
- Yazmín Gómez-Gómez
- Berenice Illades-Aguiar
- Marco Antonio Leyva-Vázquez
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Affiliations: Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, D.F., Mexico, Laboratory of Molecular Biomedicine, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico
Published online on: July 19, 2016 https://doi.org/10.3892/or.2016.4948
Pages: 1226-1232

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Abstract

MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs that play important regulatory roles by targeting mRNAs for cleavage or translational repression. miRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis. The miRNA expression is associated with specific cytogenetic changes and can also be used to discriminate between the different subtypes of leukemia in acute lymphoblastic leukemia with common translocations, it is shown that the miRNAs have the potential to be used for clinical diagnosis and prognosis. We reviewed the roles of miRNA here with emphasis on their function in human leukemia and the mechanisms of the TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins on miRNAs expression in acute lymphoblastic leukemia.

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