miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer

  • Authors:
    • Dong Wang
    • Junjie Ma
    • Xiangyu Ji
    • Feng Xu
    • Yucheng Wei
  • View Affiliations

  • Published online on: November 2, 2016     https://doi.org/10.3892/or.2016.5214
  • Pages: 608-616
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study investigated the role of miR-141 regulation of eukaryotic initiation factor-4E (EIF4E) expression in docetaxel chemoresistance of human non-small cell lung cancer (NSCLC). The expression of miR-141 in docetaxel chemoresistant patients with NSCLCs was markedly higher than those of non-docetaxel chemoresistant patients with NSCLCs. The expression of EIF4E in docetaxel chemoresistant patients with NSCLCs was markedly lower than those of non-docetaxel chemoresistant patients with NSCLCs. Downregulation of miR-141 suppressed cell proliferation, induced cell death and increased caspase-3 activity in H1299 or H2009/docetaxel cells. Downregulation of miR-141 also increased the protein expression of EIF4E, VEGF, c-Myc and Bax in H1299 or H2009/docetaxel cells. Conversely, up­regulation of miR-141 promoted cell proliferation, inhibited cell death and caspase-3 activity in H1299 or H2009/docetaxel cell. Upregulation of miR-141 suppressed EIF4E, VEGF, c-Myc protein expression and inhibited Bax in H1299 or H2009/docetaxel cells. Thus, the present study is the first to show the induction of miR-141/EIF4E expression in an acquired model of docetaxel chemoresistant patients with NSCLCs. This serves as a mechanism of acquired docetaxel chemoresistant patients with NSCLCs, possibly through direct interactions with VEGF, c-Myc, and Bax, therefore presenting a potential therapeutic target for the treatment of docetaxel chemoresistant patients with NSCLCs.
View Figures
View References

Related Articles

Journal Cover

January-2017
Volume 37 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Ma J, Ji X, Xu F and Wei Y: miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncol Rep 37: 608-616, 2017
APA
Wang, D., Ma, J., Ji, X., Xu, F., & Wei, Y. (2017). miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncology Reports, 37, 608-616. https://doi.org/10.3892/or.2016.5214
MLA
Wang, D., Ma, J., Ji, X., Xu, F., Wei, Y."miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer". Oncology Reports 37.1 (2017): 608-616.
Chicago
Wang, D., Ma, J., Ji, X., Xu, F., Wei, Y."miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer". Oncology Reports 37, no. 1 (2017): 608-616. https://doi.org/10.3892/or.2016.5214