Anticancer activity of gomisin J from Schisandra chinensis fruit

Jung,Samil; Moon,Hyung-In; Kim,Subeen; Quynh,Nguyen   Thi Ngoc; Yu,Jimin; Sandag,Zolzaya; Le,Dan-Diem   Thi; Lee,Hyegyeong; Lee,Hyojeong; Lee,Myeong-Sok

doi:10.3892/or.2018.6850

Anticancer activity of gomisin J from Schisandra chinensis fruit

Authors:
- Samil Jung
- Hyung-In Moon
- Subeen Kim
- Nguyen Thi Ngoc Quynh
- Jimin Yu
- Zolzaya Sandag
- Dan-Diem Thi Le
- Hyegyeong Lee
- Hyojeong Lee
- Myeong-Sok Lee
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Affiliations: Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea
Published online on: November 2, 2018 https://doi.org/10.3892/or.2018.6850
Pages: 711-717

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Abstract

In attempting to identify effective anticancer drugs from natural products that are harmless to humans, we found that the gomisin J from Schisandra chinensis fruit has anticancer activity. Schisandra chinensis fruits are used in traditional herbal medicine and gomisin J is one of their chemical constituents. In the present study, we examined the anticancer activity of gomisin J in MCF7 and MDA-MB-231 breast cancer cell lines and in MCF10A normal cell line, in a time- and concentration-dependent manner. Our data revealed that gomisin J exerted a much stronger cytotoxic effect on MCF7 and MDA-MB-231 cancer cells than on MCF10A normal cells. Gomisin J suppressed the proliferation and decreased the viability of MCF7 and MDA-MB-231 cells at relatively low (<10 µg/ml) and high (>30 µg/ml) concentrations, respectively. Our data also revealed that gomisin J induced necroptosis, a programmed form of necrosis, as well as apoptosis. Notably, gomisin J predominantly induced necroptosis in MCF7 cells that are known to have high resistance to many pro-apoptotic anticancer drugs, while MDA-MB-231 exhibited a much lower level of necroptosis but instead a higher level of apoptosis. This data indicated the possibility that it may be used as a more effective anticancer drug, especially in apoptosis-resistant malignant cancer cells. In an extended study, gomisin J exhibited a strong cytotoxic effect on all tested various types of 13 cancer cell lines, indicating its potential to be used against a wide range of different types of cancer cells.

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