Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis

  • Authors:
    • Li-Ping Zhou
    • Hong Luan
    • Xin-Hua Dong
    • Guo-Jiang Jin
    • Dong-Liang Man
    • Hong Shang
  • View Affiliations

  • Published online on: May 31, 2011     https://doi.org/10.3892/etm.2011.278
  • Pages: 931-936
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Abstract

The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase and CBM databases. Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2 software. From these data, the odds ratio (OR) with 95% confidence interval (CI) was calculated. Finally, 8 case-control studies were retrieved reporting a total of 2,131 gastrointestinal cancer patients and 2,670 controls. Meta-analysis results showed that there was no significant association between the VEGF +936C/T polymorphism and GC risk in all comparisons of the T allele vs. C allele (OR=1.08, 95% CI 0.90‑1.30, P=0.42), CT+TT vs. CC (OR=1.08, 95% CI 0.87-1.34, P=0.49), TT vs. CC+CT (OR=1.14, 95% CI 0.85-1.53, P=0.37), TT vs. CC (OR=1.18, 95% CI 0.87-1.59, P=0.28) and TT vs. CT (OR=1.11, 95% CI 0.79-1.56, P=0.56). This meta-analysis confirms that there is a lack of association between the VEGF +936C/T polymorphism and GC risk.
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September-October 2011
Volume 2 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou L, Luan H, Dong X, Jin G, Man D and Shang H: Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis. Exp Ther Med 2: 931-936, 2011
APA
Zhou, L., Luan, H., Dong, X., Jin, G., Man, D., & Shang, H. (2011). Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis. Experimental and Therapeutic Medicine, 2, 931-936. https://doi.org/10.3892/etm.2011.278
MLA
Zhou, L., Luan, H., Dong, X., Jin, G., Man, D., Shang, H."Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis". Experimental and Therapeutic Medicine 2.5 (2011): 931-936.
Chicago
Zhou, L., Luan, H., Dong, X., Jin, G., Man, D., Shang, H."Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis". Experimental and Therapeutic Medicine 2, no. 5 (2011): 931-936. https://doi.org/10.3892/etm.2011.278