Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice

Yuan,Huaibo; Zhu,Xiping; Chen,Deyi; Wang,Wenjuan; Meng,Shaohua; Wang,Junhui

doi:10.3892/etm.2017.4172

Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice

Authors:
- Huaibo Yuan
- Xiping Zhu
- Deyi Chen
- Wenjuan Wang
- Shaohua Meng
- Junhui Wang
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Affiliations: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui 230009, P.R. China
Published online on: March 2, 2017 https://doi.org/10.3892/etm.2017.4172
Pages: 2036-2042

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Abstract

In this study, the effects of different doses of dual modification‑treated (DMT) indica rice resistant starch (IR-RS) on azoxymethane (AOM)-induced early colon cancer in mice were investigated. The investigated factors included body weight, gastrointestinal emptying rate, the number and morphology of aberrant crypt foci (ACFs) and the specific expressions of adenomatous polyposis coli (APC), B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and cytochrome c genes. The results demonstrated that DMT IR‑RS controlled the increase in the body weights of the mice, increased the gastrointestinal emptying rates and reduced the numbers of ACFs and aberrant crypts. Reverse transcription-polymerase chain reaction revealed that DMT IR‑RS promoted the expression of APC, Bax and cytochrome c and inhibited the expression of Bcl-2. These results demonstrate that a DMT IR‑RS diet may induce apoptosis and has beneficial health effects in AOM-induced early colon cancer in mice.

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