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Article

Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice

  • Authors:
    • Huaibo Yuan
    • Xiping Zhu
    • Deyi Chen
    • Wenjuan Wang
    • Shaohua Meng
    • Junhui Wang
  • View Affiliations / Copyright

    Affiliations: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui 230009, P.R. China
  • Pages: 2036-2042
    |
    Published online on: March 2, 2017
       https://doi.org/10.3892/etm.2017.4172
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Abstract

In this study, the effects of different doses of dual modification‑treated (DMT) indica rice resistant starch (IR-RS) on azoxymethane (AOM)-induced early colon cancer in mice were investigated. The investigated factors included body weight, gastrointestinal emptying rate, the number and morphology of aberrant crypt foci (ACFs) and the specific expressions of adenomatous polyposis coli (APC), B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and cytochrome c genes. The results demonstrated that DMT IR‑RS controlled the increase in the body weights of the mice, increased the gastrointestinal emptying rates and reduced the numbers of ACFs and aberrant crypts. Reverse transcription-polymerase chain reaction revealed that DMT IR‑RS promoted the expression of APC, Bax and cytochrome c and inhibited the expression of Bcl-2. These results demonstrate that a DMT IR‑RS diet may induce apoptosis and has beneficial health effects in AOM-induced early colon cancer in mice.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan H, Zhu X, Chen D, Wang W, Meng S and Wang J: Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice. Exp Ther Med 13: 2036-2042, 2017.
APA
Yuan, H., Zhu, X., Chen, D., Wang, W., Meng, S., & Wang, J. (2017). Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice. Experimental and Therapeutic Medicine, 13, 2036-2042. https://doi.org/10.3892/etm.2017.4172
MLA
Yuan, H., Zhu, X., Chen, D., Wang, W., Meng, S., Wang, J."Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice". Experimental and Therapeutic Medicine 13.5 (2017): 2036-2042.
Chicago
Yuan, H., Zhu, X., Chen, D., Wang, W., Meng, S., Wang, J."Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2036-2042. https://doi.org/10.3892/etm.2017.4172
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan H, Zhu X, Chen D, Wang W, Meng S and Wang J: Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice. Exp Ther Med 13: 2036-2042, 2017.
APA
Yuan, H., Zhu, X., Chen, D., Wang, W., Meng, S., & Wang, J. (2017). Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice. Experimental and Therapeutic Medicine, 13, 2036-2042. https://doi.org/10.3892/etm.2017.4172
MLA
Yuan, H., Zhu, X., Chen, D., Wang, W., Meng, S., Wang, J."Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice". Experimental and Therapeutic Medicine 13.5 (2017): 2036-2042.
Chicago
Yuan, H., Zhu, X., Chen, D., Wang, W., Meng, S., Wang, J."Effects of dual modified resistant indica rice starch on azoxymethane-induced incipient colon cancer in mice". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2036-2042. https://doi.org/10.3892/etm.2017.4172
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