Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats

  • Authors:
    • Xiuting Yu
    • Guanghua Yang
    • Hua Jiang
    • Shuhai Lin
    • Yuhong Liu
    • Xie Zhang
    • Huifang Zeng
    • Ziren Su
    • Song Huang
    • Linlin Shen
    • Xiaojun Zhang
  • View Affiliations

  • Published online on: June 12, 2017     https://doi.org/10.3892/etm.2017.4577
  • Pages: 1184-1192
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Abstract

The incidence of inflammatory bowel disease (IBD), characterized by chronic, relapsing intestinal inflammation, has continually increased in recent years. A previous study by our group identified five potential metabolic markers possibly associated with the pathology of 2,4,6-trinitrobenzenesulfonic acid (TNBS)‑induced IBD in rats. The present study aimed to examine the potential therapeutic effects of the essential oil of Pogostemon cablin (also known as patchouli; PO) on TNBS‑induced rats and investigate the concomitant metabolic changes by targeting the previously identified potential markers. Pogostemon cablin is widely used to treat gastrointestinal diseases, including IBD, in China. The results of the present study showed that PO (270 mg/kg, rectal instillation) significantly alleviated colonic damage and reduced disease activity indicators and colonic myeloperoxidase in TNBS‑induced rats. In addition, a targeted metabolic profiling study identified that four metabolites were elevated in the urine of the animals in the TNBS group, which were significantly inhibited by treatment with PO: Two tryptophan metabolites [4-(2-aminophenyl)-2,4-dioxobutanoic acid and 4,6-cihydroxyquinoline] and two gut microbial metabolites (phenylacetylglycine and p‑cresol glucuronide). Taken together, these findings suggested that PO ameliorated the symptoms of TNBS‑induced IBD and reversed the metabolic changes potentially associated with TNBS‑induced IBD in rats.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu X, Yang G, Jiang H, Lin S, Liu Y, Zhang X, Zeng H, Su Z, Huang S, Shen L, Shen L, et al: Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats. Exp Ther Med 14: 1184-1192, 2017
APA
Yu, X., Yang, G., Jiang, H., Lin, S., Liu, Y., Zhang, X. ... Zhang, X. (2017). Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats. Experimental and Therapeutic Medicine, 14, 1184-1192. https://doi.org/10.3892/etm.2017.4577
MLA
Yu, X., Yang, G., Jiang, H., Lin, S., Liu, Y., Zhang, X., Zeng, H., Su, Z., Huang, S., Shen, L., Zhang, X."Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats". Experimental and Therapeutic Medicine 14.2 (2017): 1184-1192.
Chicago
Yu, X., Yang, G., Jiang, H., Lin, S., Liu, Y., Zhang, X., Zeng, H., Su, Z., Huang, S., Shen, L., Zhang, X."Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1184-1192. https://doi.org/10.3892/etm.2017.4577