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Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer

  • Authors:
    • Meng‑Ting Gong
    • Shou‑Dong Ye
    • Wen‑Wen Lv
    • Kan He
    • Wen‑Xing Li
  • View Affiliations / Copyright

    Affiliations: Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, Anhui 230601, P.R. China, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 802-810
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    Published online on: June 7, 2018
       https://doi.org/10.3892/etm.2018.6268
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Abstract

Breast cancer is one of the primary threats to women's health worldwide. However, the molecular mechanisms underlying the development of breast cancer remain to be fully elucidated. The present study aimed to investigate specific target gene expression profiles in breast cancer tissues in general and in different breast cancer stages, as well as to explore their functions in tumor development. For integrated analysis, a total of 5 gene expression profiling datasets for 3 different stages of breast cancer (stages I‑III) were downloaded from the Gene Expression Omnibus of the National Center for Biotechnology Information. Pre‑processing of these datasets was performed using the Robust Multi‑array Average algorithm and global renormalization was performed for all studies. Differentially expressed genes between breast cancer patients and controls were estimated using the empirical Bayes algorithm. The Database for Annotation, Visualization and Integrated Discovery web server was used for analyzing the enrichment of the differentially expressed genes in Gene Ontology terms of the category biological process and in Kyoto Encyclopedia of Genes and Genomes pathways. Furthermore, breast cancer target genes were downloaded from the Thomson Reuters Integrity Database. We merged these target genes with the genes in breast cancer datasets. Analysis of anti‑breast cancer gene networks was performed using the Genome‑scale Integrated Analysis of Gene Networks in Tissues web server. The results demonstrated that the normal functions of the cell cycle, cell migration and cell adhesion were altered in all stages of breast cancer. Furthermore, 12 anti‑breast cancer genes were identified to be dysregulated in at least one of the three stages. Among all of these genes, ribonucleotide reductase regulatory subunit M2 (RRM2) exhibited the highest degree of interaction with other interacting genes. Analysis of the network interactions revealed that the transcription factor of RRM2 is crucial for cancer development. Other genes, including mucin 1, progesterone receptor and cyclin‑dependent kinase 5 regulatory subunit associated protein 3, also exhibited a high degree of interaction with the associated genes. In conclusion, several key anti‑breast cancer genes identified in the present study are mainly associated with the regulation of the cell cycle, cell migration, cell adhesion and other cancer‑associated cell functions, particularly RRM2.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Global Burden of Disease Cancer Collaboration, . Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3:524–548. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

O'Shaughnessy J: Extending survival with chemotherapy in metastatic breast cancer. Oncologist. 10 Suppl 3:S20–S29. 2005. View Article : Google Scholar

5 

Huang CS, Lin CH, Lu YS and Shen CY: Unique features of breast cancer in Asian women-breast cancer in Taiwan as an example. J Steroid Biochem Mol Biol. 118:300–303. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Reddy SM, Barcenas CH, Sinha AK, Hsu L, Moulder SL, Tripathy D, Hortobagyi GN and Valero V: Long-term survival outcomes of triple-receptor negative breast cancer survivors who are disease free at 5 years and relationship with low hormone receptor positivity. Br J Cancer. 118:17–23. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, Weaver DL, Winchester DJ and Hortobagyi GN: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67:290–303. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Locke WJ and Clark SJ: Epigenome remodelling in breast cancer: Insights from an early in vitro model of carcinogenesis. Breast Cancer Res. 14:2152012. View Article : Google Scholar : PubMed/NCBI

9 

Harvell DM, Kim J, O'Brien J, Tan AC, Borges VF, Schedin P, Jacobsen BM and Horwitz KB: Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Cancer. 4:140–153. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mobasheri MB, Shirkoohi R, Zendehdel K, Jahanzad I, Talebi S, Afsharpad M and Modarressi MH: Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines. Tumour Biol. 36:8201–8206. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Nogales-Cadenas R, Cai Y, Lin JR, Zhang Q, Zhang W, Montagna C and Zhang ZD: MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice. Breast Cancer Res. 18:752016. View Article : Google Scholar : PubMed/NCBI

12 

Lang JE, Scott JH, Wolf DM, Novak P, Punj V, Magbanua MJ, Zhu W, Mineyev N, Haqq CM, Crothers JR, et al: Expression profiling of circulating tumor cells in metastatic breast cancer. Breast Cancer Res Treat. 149:121–131. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Li WX, He K, Tang L, Dai SX, Li GH, Lv WW, Guo YC, An SQ, Wu GY, Liu D, et al: Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets. Oncotarget. 8:6775–6786. 2016.

14 

Miyoshi K and Hennighausen L: Beta-catenin: A transforming actor on many stages. Breast Cancer Res. 5:63–68. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, et al: DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434:864–870. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Wu H, Chen Y, Liang J, Shi B, Wu G, Zhang Y, Wang D, Li R, Yi X, Zhang H, et al: Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature. 438:981–987. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:(Database Issue). D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Pedraza V, Gomez-Capilla JA, Escaramis G, Gomez C, Torné P, Rivera JM, Gil A, Araque P, Olea N, Estivill X and Fárez-Vidal ME: Gene expression signatures in breast cancer distinguish phenotype characteristics, histologic subtypes, and tumor invasiveness. Cancer. 116:486–496. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Desmedt C, Giobbie-Hurder A, Neven P, Paridaens R, Christiaens MR, Smeets A, Lallemand F, Haibe-Kains B, Viale G, Gelber RD, et al: The Gene expression Grade Index: A potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1–98 trial. BMC Med Genomics. 2:402009. View Article : Google Scholar : PubMed/NCBI

21 

Lopez FJ, Cuadros M, Cano C, Concha A and Blanco A: Biomedical application of fuzzy association rules for identifying breast cancer biomarkers. Med Biol Eng Comput. 50:981–990. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Clarke C, Madden SF, Doolan P, Aherne ST, Joyce H, O'Driscoll L, Gallagher WM, Hennessy BT, Moriarty M, Crown J, et al: Correlating transcriptional networks to breast cancer survival: A large-scale coexpression analysis. Carcinogenesis. 34:2300–2308. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Aswad L, Yenamandra SP, Ow GS, Grinchuk O, Ivshina AV and Kuznetsov VA: Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development. Oncotarget. 6:36652–36674. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Carvalho BS and Irizarry RA: A framework for oligonucleotide microarray preprocessing. Bioinformatics. 26:2363–2367. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Li WX, Dai SX, Wang Q, Guo YC, Hong Y, Zheng JJ, Liu JQ, Liu D, Li GH and Huang JF: Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets. PeerJ. 4:e24702016. View Article : Google Scholar : PubMed/NCBI

26 

Li WX, Dai SX, Liu JQ, Wang Q, Li GH and Huang JF: Integrated analysis of Alzheimer's disease and schizophrenia dataset revealed different expression pattern in learning and memory. J Alzheimers Dis. 51:417–425. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

28 

da Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, et al: Understanding multicellular function and disease with human tissue-specific networks. Nat Genet. 47:569–576. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Liu Z, Zhan Y, Tu Y, Chen K, Liu Z and Wu C: PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with a-actinin. Oncogene. 34:1300–1311. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Dong H, Claffey KP, Brocke S and Epstein PM: Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 152:17–28. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Cacace A, Sboarina M, Vazeille T and Sonveaux P: Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism. Oncogene. 36:2074–2084. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Apostoli AJ, Roche JM, Schneider MM, SenGupta SK, Di Lena MA, Rubino RE, Peterson NT and Nicol CJ: Opposing roles for mammary epithelial-specific PPARg signaling and activation during breast tumour progression. Mol Cancer. 14:852015. View Article : Google Scholar : PubMed/NCBI

34 

El-Rayes BF, Ali S, Heilbrun LK, Lababidi S, Bouwman D, Visscher D and Philip PA: Cytochrome p450 and glutathione transferase expression in human breast cancer. Clin Cancer Res. 9:1705–1709. 2003.PubMed/NCBI

35 

Leung T, Rajendran R, Singh S, Garva R, Krstic-Demonacos M and Demonacos C: Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res. 15:R1072013. View Article : Google Scholar : PubMed/NCBI

36 

Davydov DR, Davydova NY, Rodgers JT, Rushmore TH and Jones JP: Toward a systems approach to the human cytochrome P450 ensemble: Interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochem J. 474:3523–3542. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Li Y, Steppi A, Zhou Y, Mao F, Miller PC, He MM, Zhao T, Sun Q and Zhang J: Tumoral expression of drug and xenobiotic metabolizing enzymes in breast cancer patients of different ethnicities with implications to personalized medicine. Sci Rep. 7:47472017. View Article : Google Scholar : PubMed/NCBI

38 

Braak Ter B, Siezen CL, Lee JS, Rao P, Voorhoeve C, Ruppin E, van der Laan JW and van de Water B: Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production. Breast Cancer Res. 19:142017. View Article : Google Scholar : PubMed/NCBI

39 

Shi J, Aronson KJ, Grundy A, Kobayashi LC, Burstyn I, Schuetz JM, Lohrisch CA, SenGupta SK, Lai AS, Brooks-Wilson A, et al: Polymorphisms of insulin-like growth factor 1 pathway genes and breast cancer risk. Front Oncol. 6:1362016. View Article : Google Scholar : PubMed/NCBI

40 

MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson JP and Matthews J: 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 41:1604–1621. 2013. View Article : Google Scholar : PubMed/NCBI

41 

McKay J, Tenet V, Franceschi S, Chabrier A, Gheit T, Gaborieau V, Chopin S, Avogbe PH, Tommasino M, Ainouze M, et al: Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study. PLoS One. 12:e01777752017. View Article : Google Scholar : PubMed/NCBI

42 

Maltepe E, Keith B, Arsham AM, Brorson JR and Simon MC: The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem Biophys Res Commun. 273:231–238. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Qin XY, Wei F, Yoshinaga J, Yonemoto J, Tanokura M and Sone H: siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells. FEBS Lett. 585:3310–3315. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Yang E, Hu XF and Xing PX: Advances of MUC1 as a target for breast cancer immunotherapy. Histol Histopathol. 22:905–922. 2007.PubMed/NCBI

45 

Varga Z, Lebeau A, Bu H, Hartmann A, Penault-Llorca F, Guerini-Rocco E, Schraml P, Symmans F, Stoehr R, Teng X, et al: An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®. Breast Cancer Res. 19:552017. View Article : Google Scholar : PubMed/NCBI

46 

Putluri N, Maity S, Kommagani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, et al: Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 16:390–402. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Shah KN, Wilson EA, Malla R, Elford HL and Faridi JS: targeting ribonucleotide reductase M2 and NF-κB activation with didox to circumvent tamoxifen resistance in breast cancer. Mol Cancer Ther. 14:2411–2421. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Hiraki M, Maeda T, Bouillez A, Alam M, Tagde A, Hinohara K, Suzuki Y, Markert T, Miyo M, Komura K, et al: MUC1-C activates BMI1 in human cancer cells. Oncogene. 36:2791–2801. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Raina D, Uchida Y, Kharbanda A, Rajabi H, Panchamoorthy G, Jin C, Kharbanda S, Scaltriti M, Baselga J and Kufe D: Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells. Oncogene. 33:3422–3431. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Ishizawar RC, Miyake T and Parsons SJ: c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function. Oncogene. 26:3503–3510. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Dominguez-Brauer C, Thu KL, Mason JM, Blaser H, Bray MR and Mak TW: Targeting mitosis in cancer: Emerging strategies. Mol Cell. 60:524–536. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Chen L, Jenjaroenpun P, Pillai AM, Ivshina AV, Ow GS, Efthimios M, Zhiqun T, Tan TZ, Lee SC, Rogers K, et al: Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification. Proc Natl Acad Sci USA. 114:E2215–E2224. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong MT, Ye SD, Lv WW, He K and Li WX: Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer. Exp Ther Med 16: 802-810, 2018.
APA
Gong, M., Ye, S., Lv, W., He, K., & Li, W. (2018). Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer. Experimental and Therapeutic Medicine, 16, 802-810. https://doi.org/10.3892/etm.2018.6268
MLA
Gong, M., Ye, S., Lv, W., He, K., Li, W."Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer". Experimental and Therapeutic Medicine 16.2 (2018): 802-810.
Chicago
Gong, M., Ye, S., Lv, W., He, K., Li, W."Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer". Experimental and Therapeutic Medicine 16, no. 2 (2018): 802-810. https://doi.org/10.3892/etm.2018.6268
Copy and paste a formatted citation
x
Spandidos Publications style
Gong MT, Ye SD, Lv WW, He K and Li WX: Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer. Exp Ther Med 16: 802-810, 2018.
APA
Gong, M., Ye, S., Lv, W., He, K., & Li, W. (2018). Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer. Experimental and Therapeutic Medicine, 16, 802-810. https://doi.org/10.3892/etm.2018.6268
MLA
Gong, M., Ye, S., Lv, W., He, K., Li, W."Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer". Experimental and Therapeutic Medicine 16.2 (2018): 802-810.
Chicago
Gong, M., Ye, S., Lv, W., He, K., Li, W."Comprehensive integrated analysis of gene expression datasets identifies key anti‑cancer targets in different stages of breast cancer". Experimental and Therapeutic Medicine 16, no. 2 (2018): 802-810. https://doi.org/10.3892/etm.2018.6268
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