Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Improved heart failure by Rhein lysinate is associated with p38MAPK pathway

  • Authors:
    • Wei Wang
    • Xin Meng
    • Jing Wang
    • Yong Li
  • View Affiliations / Copyright

    Affiliations: Internal Medicine-Cardiovascular Department, Tengzhou Central People's Hospital Affiliated to Jining Medical University, Zaozhuang, Shandong 277500, P.R. China
  • Pages: 2046-2051
    |
    Published online on: July 9, 2018
       https://doi.org/10.3892/etm.2018.6423
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to explore the role of Rhein lysinate (RHL) in neonatal rat ventricular myocytes (NRVMs) and congestive heart failure induced by co‑arctation of the abdominal aorta. Male Sprague‑Dawley rats were divided into 3 groups randomly: co‑arctation of abdominal aorta group (A group, n=10), sham operation group (SH group, n=10) and RHL treatment rats (A+RHL group, n=10). To establish an in vitro oxidative stressed cardiomyocyte model, NRVMs were treated with 10 µM H2O2 for 24 h. MTT assay indicated that H2O2 treatment reduced primary cardiomyocyte viability in a time‑ and dose‑ dependent manner, whereas RHL abolished the detrimental effects of H2O2, indicating a protective role of RHL. Further study demonstrated that H2O2‑induced reactive oxygen species (ROS) production was reversed by RHL. Then, TUNEL staining was carried out and the results revealed that H2O2 markedly enhanced primary cardiomyocyte apoptosis. Conversely, RHL incubation decreased H2O2‑induced cell apoptosis, indicating the protective role of RHL in primary cardiomyocytes. Furthermore, abnormal p38 activation was identified in the failed heart. Notably, treatment with RHL reduced p38 activation. In addition, RHL significantly enhanced the expression of anti‑apoptotic protein, B cell lymphoma (Bcl)‑2, however markedly reduced the protein level of Bcl‑2 associated X, apoptosis regulator in primary cardiomyocytes, indicating its anti‑apoptotic role in the cardiac setting. Overall, RHL protects heart failure primarily by reducing ROS production and cardiomyocyte apoptosis via suppressing p38 mitogen activated protein kinase activation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Suzuki H, Nodera M, Kamioka M, Kaneshiro T, Kamiyama Y and Takeishi Y: Intracardiac impedance after cardiac resynchronization therapy is a novel predictor for worsening of heart failure. Heart Vessels. 32:926–931. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Senni M, D'Elia E, Emdin M and Vergaro G: Biomarkers of heart failure with preserved and reduced ejection fraction. Handb Exp Pharmacol. 243:79–108. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Pecoraro A, Crescenzi L, Carucci L, Genovese A and Spadaro G: Heart failure not responsive to standard immunosuppressive therapy is successfully treated with high dose intravenous immunoglobulin therapy in a patient with eosinophilic granulomatosis with polyangiitis (EGPA). Int Immunopharmacol. 45:13–15. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Marx N: Heart failure and diabetes-underestimated, underdiagnosed and poorly understood: A call for action. Diab Vasc Dis Res. 14:67–68. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Mathur A, Fernández-Avilés F, Dimmeler S, Hauskeller C, Janssens S, Menasche P, Wojakowski W, Martin JF and Zeiher A: BAMI Investigators: The consensus of the Task Force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for the treatment of acute myocardial infarction and heart failure: Update 2016. Eur Heart J. Feb 15–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

6 

Arabacilar P and Marber M: The case for inhibiting p38 mitogen-activated protein kinase in heart failure. Front Pharmacol. 6:1022015. View Article : Google Scholar : PubMed/NCBI

7 

Cook SA, Sugden PH and Clerk A: Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease. J Mol Cell Cardiol. 31:1429–1434. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Di Lisa F, Kaludercic N and Paolocci N: β2-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: Another ‘radical’ road to heart failure? Br J Pharmacol. 162:1009–1011. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Marber MS, Rose B and Wang Y: The p38 mitogen-activated protein kinase pathway-a potential target for intervention in infarction, hypertrophy, and heart failure. J Mol Cell Cardiol. 51:485–490. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wei J, Zhen YZ, Cui J, He FL, Shen T, Hu G, Ren XH and Lin YJ: Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease. Arch Pharm Res. 39:960–969. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Lin YJ, Zhen YZ, Wei J, Liu B, Yu ZY and Hu G: Effects of Rhein lysinate on H2O2-induced cellular senescence of human umbilical vascular endothelial cells. Acta Pharmacol Sin. 32:1246–1252. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Lin YJ, Zhen YZ, Zhao YF, Wei J and Hu G: Rhein lysinate induced S-phase arrest and increased the anti-tumor activity of 5-FU in HeLa cells. Am J Chin Med. 39:817–825. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Hannan RD, Luyken J and Rothblum LI: Regulation of ribosomal DNA transcription during contraction-induced hypertrophy of neonatal cardiomyocytes. J Biol Chem. 271:3213–3220. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Song B, Li T, Chen S, Yang D, Luo L, Wang T, Han X, Bai L and Ma A: Correlations between MTP and ros levels of peripheral blood lymphocytes and readmission in patients with chronic heart failure. Heart Lung Circ. 25:296–302. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Rojas A, Mercadal E, Figueroa H and Morales MA: Advanced Glycation and ROS: A link between diabetes and heart failure. Curr Vasc Pharmacol. 6:44–51. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Astashkin EI, Glezer MG, Vinokurov MG, Egorova ND, Orekhova NS, Novikova AN, Grachev SV, Yurinskaya MM and Sobolev KE: Actovegin reduces the ROS level in blood samples of heart failure patients and diminishes necrosis of SK-N-SH human neuroblastoma cells. Dokl Biol Sci. 448:57–60. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Borchi E, Bargelli V, Stillitano F, Giordano C, Sebastiani M, Nassi PA, d'Amati G, Cerbai E and Nediani C: Enhanced ROS production by NADPH oxidase is correlated to changes in antioxidant enzyme activity in human heart failure. Biochim Biophys Acta. 1802:331–338. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Liu J, Zhang K, Zhen YZ, Wei J, Hu G, Gao JL, Tian YX and Lin YJ: Antitumor activity of rhein lysinate against human glioma U87 cells in vitro and in vivo. Oncol Rep. 35:1711–1717. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Lin YJ, Hu G, Li KJ, Zhao YF, Wei J and Zhen YZ: The protection of Rhein lysinate to liver in diabetic mice induced by high-fat diet and streptozotocin. Arch Pharm Res. 38:885–892. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Hafstad AD, Nabeebaccus AA and Shah AM: Novel aspects of ROS signalling in heart failure. Basic Res Cardiol. 108:3592013. View Article : Google Scholar : PubMed/NCBI

21 

Zuo L, Chuang CC, Hemmelgarn BT and Best TM: Heart failure with preserved ejection fraction: Defining the function of ROS and NO. J Appl Physiol (1985). 119:944–951. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Heusch P, Canton M, Aker S, van de Sand A, Konietzka I, Rassaf T, Menazza S, Brodde OE, Di Lisa F, Heusch G and Schulz R: The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits. Br J Pharmacol. 160:1408–1416. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Hoefer J, Azam MA, Kroetsch JT, Leong-Poi H, Momen MA, Voigtlaender-Bolz J, Scherer EQ, Meissner A, Bolz SS and Husain M: Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. Circ Res. 107:923–933. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Kerkela R and Force T: p38 mitogen-activated protein kinase: A future target for heart failure therapy? J Am Coll Cardiol. 48:556–558. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Kita T, Ogawa M, Sato H, Kasai K, Tanaka T and Tanaka N: Role of p38 mitogen-activated protein kinase pathway on heart failure in the infant rat after burn injury. Int J Exp Pathol. 89:55–63. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Nemoto S, Sheng Z and Lin A: Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol. 18:3518–3526. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Irukayama-Tomobe Y, Miyauchi T, Kasuya Y, Sakai S, Goto K and Yamaguchi I: Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes. J Cardiovasc Pharmacol. 44 Suppl 1:S358–S361. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Inagaki K, Satoh T, Yagi-Utsumi M, Le Gulluche AC, Anzai T, Uekusa Y, Kamiya Y and Kato K: Redox-coupled structural changes of the catalytic a' domain of protein disulfide isomerase. FEBS Lett. 589:2690–2694. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zhang D, Gaussin V, Taffet GE, Belaguli NS, Yamada M, Schwartz RJ, Michael LH, Overbeek PA and Schneider MD: TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med. 6:556–563. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang W, Meng X, Wang J and Li Y: Improved heart failure by Rhein lysinate is associated with p38MAPK pathway. Exp Ther Med 16: 2046-2051, 2018.
APA
Wang, W., Meng, X., Wang, J., & Li, Y. (2018). Improved heart failure by Rhein lysinate is associated with p38MAPK pathway. Experimental and Therapeutic Medicine, 16, 2046-2051. https://doi.org/10.3892/etm.2018.6423
MLA
Wang, W., Meng, X., Wang, J., Li, Y."Improved heart failure by Rhein lysinate is associated with p38MAPK pathway". Experimental and Therapeutic Medicine 16.3 (2018): 2046-2051.
Chicago
Wang, W., Meng, X., Wang, J., Li, Y."Improved heart failure by Rhein lysinate is associated with p38MAPK pathway". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2046-2051. https://doi.org/10.3892/etm.2018.6423
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Meng X, Wang J and Li Y: Improved heart failure by Rhein lysinate is associated with p38MAPK pathway. Exp Ther Med 16: 2046-2051, 2018.
APA
Wang, W., Meng, X., Wang, J., & Li, Y. (2018). Improved heart failure by Rhein lysinate is associated with p38MAPK pathway. Experimental and Therapeutic Medicine, 16, 2046-2051. https://doi.org/10.3892/etm.2018.6423
MLA
Wang, W., Meng, X., Wang, J., Li, Y."Improved heart failure by Rhein lysinate is associated with p38MAPK pathway". Experimental and Therapeutic Medicine 16.3 (2018): 2046-2051.
Chicago
Wang, W., Meng, X., Wang, J., Li, Y."Improved heart failure by Rhein lysinate is associated with p38MAPK pathway". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2046-2051. https://doi.org/10.3892/etm.2018.6423
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team