Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies
- Authors:
- Liuqing Yang
- Shuying Liu
- Wei Fang
- Jun Chen
- Yu Chen
- Published online on: October 23, 2019 https://doi.org/10.3892/etm.2019.8121
- Pages: 4874-4880
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Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
The aim of the present study was to investigate the feasibility of using composite scaffolds of poly(lactic‑co‑glycolic acid) (PLGA) and bioactive glass (BG) to repair bone defects. PLGA/BG composite scaffolds were prepared by thermally‑induced phase separation. Scanning electron microscopy (SEM) was used to study the morphology, and liquid (absolute ethanol) replacement was used to calculate the porosity of the scaffold. The biocompatibility and degradation of the scaffold were determined using human osteosarcoma cell line MG‑63 and animal experiments. SEM showed that the scaffold had a nanofibrous three‑dimensional network structure with a fiber diameter of 160‑320 nm, a pore size of 1‑7 µm, and a porosity of 93.048±0.121%. The scaffold structure was conducive to cell adhesion and proliferation. It promoted cell osteogenesis and could be stably degraded in vivo.
