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Article

Skin ‑ a vast organ with immunological function (Review)

  • Authors:
    • Minela Aida Maranduca
    • Loredana Liliana Hurjui
    • Daniel Constantin Branisteanu
    • Dragomir Nicolae Serban
    • Daciana Elena Branisteanu
    • Nicoleta Dima
    • Ionela Lacramioara Serban
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Opthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Dermatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
  • Pages: 18-23
    |
    Published online on: March 20, 2020
       https://doi.org/10.3892/etm.2020.8619
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Abstract

The skin is an organ with multiple functions, where important inflammatory and immunological processes take place. The integrity of the skin barrier is necessary for it to fulfill its roles. An intact skin barrier requires a physiological keratinization process, but also a normal cutaneous microbial flora. Any change in the proliferation and differentiation of keratinocytes entails the disruption of the skin barrier and the triggering of inflammatory and immunological processes at this level, in response to the aggression of external pathogens. Also, there are several specialised immune cells in the skin (Langerhans cells, T regulator cells, T helper cells), that maintain a balance between pro‑inflammatory and anti‑inflammatory processes at this level. Disturbing the immune homeostasis causes inflammation and allergic skin reaction. Psoriasis and atopic dermatitis are two inflammatory diseases of the skin, characterized by perturbation of the mechanisms of skin barrier formation. The immune system of the skin is also involved in the pathophysiology of vitiligo and pemphigus. The aim of this review is to offer a brief presentation of the inflammatory and immunological processes that occur in the skin.
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1 

Maranduca MA, Branisteanu D, Serban DN, Branisteanu DC, Stoleriu G, Manolache N and Serban IL: Synthesis and physiological implications of melanic pigments. Oncol Lett. 17:4183–4187. 2019.PubMed/NCBI View Article : Google Scholar

2 

Hänel KH, Cornelissen C, Lüscher B and Baron JM: Cytokines and the skin barrier. Int J Mol Sci. 14:6720–6745. 2013.PubMed/NCBI View Article : Google Scholar

3 

Ilie MA, Caruntu C, Tampa M, Georgescu SR, Matei C, Negrei C, Ion RM, Constantin C, Neagu M and Boda D: Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions. Exp Ther Med. 18:916–925. 2019.PubMed/NCBI View Article : Google Scholar

4 

Branisteanu D, Caruntu C, Negrei C, Ghita MA, Caruntu A, Badarau AI, Buraga I, Boda D and Albu A: Capsaicin, a hot topic in skin pharmacology and physiology. Farmacia. 63:487–491. 2015.

5 

Căruntu C, Boda D, Musat S, Căruntu A and Mandache E: Stress-induced mast cell activation in glabrous and hairy skin. Mediators Inflamm. 2014(105950)2014.PubMed/NCBI View Article : Google Scholar

6 

Guttman-Yassky E, Nograles KE and Krueger JG: Contrasting pathogenesis of atopic dermatitis and psoriasis - part I: Clinical and pathologic concepts. J Allergy Clin Immunol. 127:1110–1118. 2011.PubMed/NCBI View Article : Google Scholar

7 

Caruntu C, Boda D, Musat S, Caruntu A, Poenaru E, Calenic B, Savulescu-Fiedler I, Draghia A, Rotaru M and Badarau AI: Stress effects on cutaneous nociceptive nerve fibers and their neurons of origin in rats. Rom Biotechnol Lett. 19:9517–9530. 2014.

8 

Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, et al: Neuroendocrine factors: The missing link in non melanoma skin cancer (Review). Oncol Rep. 38:1327–1340. 2017.PubMed/NCBI View Article : Google Scholar

9 

International Federation of Psoriasis Associations: World Psoriasis Day, 2015. Available at: https://ifpa-pso.com/2015/10/29/press-world-psoriasis-day-2015-brings-hope.

10 

Parisi R, Symmons DP, Griffiths CE and Ashcroft DM: Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team. Global epidemiology of psoriasis: A systematic review of incidence and prevalence. J Invest Dermatol. 133:377–385. 2013.PubMed/NCBI View Article : Google Scholar

11 

Taïeb A and Picardo M: Clinical practice. Vitiligo. N Engl J Med. 360:160–169. 2009.PubMed/NCBI View Article : Google Scholar

12 

Alkhateeb A, Fain PR, Thody A, Bennett DC and Spritz RA: Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res. 16:208–214. 2003.PubMed/NCBI View Article : Google Scholar

13 

Proksch E, Brandner JM and Jensen JM: The skin: An indispensable barrier. Exp Dermatol. 17:1063–1072. 2008.PubMed/NCBI View Article : Google Scholar

14 

Freeman SC and Sonthalia S: Histology, Keratohyalin Granules. StatPearls Publishing, Treasure Island, FL, 2019.

15 

Harder J, Schröder JM and Gläser R: The skin surface as antimicrobial barrier: Present concepts and future outlooks. Exp Dermatol. 22:1–5. 2013.PubMed/NCBI View Article : Google Scholar

16 

Gallo RL and Hooper LV: Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 12:503–516. 2012.PubMed/NCBI View Article : Google Scholar

17 

Manabe M and O'Guin WM: Keratohyalin, trichohyalin and keratohyalin-trichohyalin hybrid granules: An overview. J Dermatol. 19:749–755. 1992.PubMed/NCBI View Article : Google Scholar

18 

Nithya S, Radhika T and Jeddy N: Loricrin - an overview. J Oral Maxillofac Pathol. 19:64–68. 2015.PubMed/NCBI View Article : Google Scholar

19 

Westerhof W and Dingemans KP: The morphology of keratohyalin granules in orthokeratotic and parakeratotic skin and oral mucosa. Int J Dermatol. 26:308–313. 1987.PubMed/NCBI View Article : Google Scholar

20 

Yousef H, Alhajj M and Sharma S: Anatomy, Skin (Integument), Epidermis. StatPearls Publishing, Treasure Island, FL, 2019.

21 

Westerhof W and Dingemans KP: The morphological details of globular keratohyalin granules. J Cutan Pathol. 13:375–382. 1986.PubMed/NCBI View Article : Google Scholar

22 

Dinh MH, McRaven MD, Kelley Z, Penugonda S and Hope TJ: Keratinization of the adult male foreskin and implications for male circumcision. AIDS. 24:899–906. 2010.PubMed/NCBI View Article : Google Scholar

23 

Takahashi M, Horiuchi Y and Tezuka T: Hematoxylin-stainability of keratohyalin granules is due to the novel component, fibrinogen γ-chain protein. Arch Dermatol Res. 302:679–684. 2010.PubMed/NCBI View Article : Google Scholar

24 

Fukuyama K and Epstein WL: Heterogeneous ultrastructure of keratohyalin granules: A comparative study of adjacent skin and mucous membrane. J Invest Dermatol. 61:94–100. 1973.PubMed/NCBI View Article : Google Scholar

25 

Nwabudike LC, Elisei AM, Buzia OD, Miulescu M and Tatu AL: Statins: A review on structural perspectives, adverse reactions and relations with non-melanoma skin cancer. Rev Chim Buchar. 69:2557–2562. 2018.

26 

Cioplea M, Caruntu C, Zurac S, Bastian A, Sticlaru L, Cioroianu A, Boda D, Jugulete G, Nichita L and Popp C: Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma. Oncol Lett. 17:4055–4059. 2019.PubMed/NCBI View Article : Google Scholar

27 

Steinman RM and Cohn ZA: Identification of a novel cell type in peripheral lymphoid organs of mice I. Morphology, quantitation, tissue distribution. J Exp Med. 137:1142–1162. 1973.PubMed/NCBI View Article : Google Scholar

28 

Rajesh A, Wise L and Hibma M: The role of Langerhans cells in pathologies of the skin. Immunol Cell Biol. 97:700–713. 2019.PubMed/NCBI View Article : Google Scholar

29 

Nirschl CJ and Anandasabapathy N: Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance. Hum Vaccin Immunother. 12:104–116. 2016.PubMed/NCBI View Article : Google Scholar

30 

Teunissen MBM, Haniffa M and Collin MP: Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design. Curr Top Microbiol Immunol. 351:25–76. 2012.PubMed/NCBI View Article : Google Scholar

31 

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, et al: Commensal microbes and hair follicle morphogenesis coordinately drive treg migration into neonatal skin. Cell Host Microbe. 21:467–477.e5. 2017.PubMed/NCBI View Article : Google Scholar

32 

Brănişteanu DE, Pintilie A, Andreş LE, Dimitriu A, Oanţă A, Stoleriu G and Brănişteanu DC: Ethiopatogenic hypotheses in lichen planus. Rev Med Chir Soc Med Nat Iasi. 120:760–767. 2016.PubMed/NCBI

33 

Brănişteanu DE, Brănişteanu DC, Stoleriu G, Ferariu D, Voicu CM, Stoica LE, Căruntu C, Boda D, Filip-Ciubotaru FM, Dimitriu A, et al: Histopathological and clinical traps in lichen sclerosus: A case report. Rom J Morphol Embryol. 57 (Suppl 2):817–823. 2016.PubMed/NCBI

34 

Sakaguchi S, Yamaguchi T, Nomura T and Ono M: Regulatory T cells and immune tolerance. Cell. 133:775–787. 2008.PubMed/NCBI View Article : Google Scholar

35 

Tang L and Wang K: Chronic inflammation in skin malignancies. J Mol Signal. 11(2)2016.PubMed/NCBI View Article : Google Scholar

36 

Suwanpradid J, Holcomb ZE and MacLeod AS: Emerging skin T-cell functions in response to environmental insults. J Invest Dermatol. 137:288–294. 2017.PubMed/NCBI View Article : Google Scholar

37 

Ali N and Rosenblum MD: Regulatory T cells in skin. Immunology. 152:372–381. 2017.PubMed/NCBI View Article : Google Scholar

38 

Boda D: Cellomics as integrative omics for cancer. Curr Proteomics. 10:237–245. 2013.

39 

Sakaguchi S, Vignali DA, Rudensky AY, Niec RE and Waldmann H: The plasticity and stability of regulatory T cells. Nat Rev Immunol. 13:461–467. 2013.PubMed/NCBI View Article : Google Scholar

40 

Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS and Clark RA: Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med. 6(219ra8)2014.PubMed/NCBI View Article : Google Scholar

41 

Kaplan MH, Hufford MM and Olson MR: The development and in vivo function of T helper 9 cells. Nat Rev Immunol. 15:295–307. 2015.PubMed/NCBI View Article : Google Scholar

42 

Liu J, Harberts E, Tammaro A, Girardi N, Filler RB, Fishelevich R, Temann A, Licona-Limón P, Girardi M, Flavell RA, et al: IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis. J Invest Dermatol. 134:1903–1911. 2014.PubMed/NCBI View Article : Google Scholar

43 

Ma L, Xue HB, Guan XH, Shu CM, Zhang JH and Yu J: Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clin Exp Immunol. 175:25–31. 2014.PubMed/NCBI View Article : Google Scholar

44 

World Health Organization: Global report on psoriasis. World Health Organization, Geneva,. 2016, ISBN 978 92 4 156518 9. Available at: https://apps.who.int/iris/handle/10665/204417.

45 

Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ and Troxel AB: Risk of myocardial infarction in patients with psoriasis. JAMA. 296:1735–1741. 2006.PubMed/NCBI View Article : Google Scholar

46 

Solomon I, Voiculescu VM, Caruntu C, Lupu M, Popa A, Ilie MA, Albulescu R, Caruntu A, Tanase C, Constantin C, et al: Neuroendocrine factors and head and neck squamous cell carcinoma: An affair to remember. Dis Markers. 2018(9787831)2018.PubMed/NCBI View Article : Google Scholar

47 

Batycka-Baran A, Maj J, Wolf R and Szepietowski JC: The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis. J Immunol Res. 2014(628289)2014.PubMed/NCBI View Article : Google Scholar

48 

Dunphy SE, Sweeney CM, Kelly G, Tobin AM, Kirby B and Gardiner CM: Natural killer cells from psoriasis vulgaris patients have reduced levels of cytotoxicity associated degranulation and cytokine production. Clin Immunol. 177:43–49. 2017.PubMed/NCBI View Article : Google Scholar

49 

Grigore O, Mihailescu AI, Solomon I, Boda D and Caruntu C: Role of stress in modulation of skin neurogenic inflammation. Exp Ther Med. 17:997–1003. 2019.PubMed/NCBI View Article : Google Scholar

50 

Witte E, Kokolakis G, Witte K, Philipp S, Doecke WD, Babel N, Wittig BM, Warszawska K, Kurek A, Erdmann-Keding M, et al: IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis. J Invest Dermatol. 134:2757–2767. 2014.PubMed/NCBI View Article : Google Scholar

51 

Nograles KE, Zaba LC, Guttman-Yassky E, Fuentes-Duculan J, Suárez-Fariñas M, Cardinale I, Khatcherian A, Gonzalez J, Pierson KC, White TR, et al: Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br J Dermatol. 159:1092–1102. 2008.PubMed/NCBI View Article : Google Scholar

52 

Chen W, Gong Y, Zhang X, Tong Y, Wang X, Fei C, Xu H, Yu Q, Wang Y and Shi Y: Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model. J Dermatol Sci. 85:115–123. 2017.PubMed/NCBI View Article : Google Scholar

53 

Caruntu C, Boda D, Dumitrascu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomarkers Med. 9:513–528. 2015.PubMed/NCBI View Article : Google Scholar

54 

Harris JE: Cellular stress and innate inflammation in organ-specific autoimmunity: Lessons learned from vitiligo. Immunol Rev. 269:11–25. 2016.PubMed/NCBI View Article : Google Scholar

55 

Goronzy J, Weyand CM and Waase I: T cell subpopulations in inflammatory bowel disease: Evidence for a defective induction of T8+ suppressor/cytotoxic T lymphocytes. Clin Exp Immunol. 61:593–600. 1985.PubMed/NCBI

56 

Ongenae K, Van Geel N and Naeyaert JM: Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res. 16:90–100. 2003.PubMed/NCBI View Article : Google Scholar

57 

Grimes PE, Morris R, Avaniss-Aghajani E, Soriano T, Meraz M and Metzger A: Topical tacrolimus therapy for vitiligo: Therapeutic responses and skin messenger RNA expression of proinflammatory cytokines. J Am Acad Dermatol. 51:52–61. 2004.PubMed/NCBI View Article : Google Scholar

58 

Birol A, Kisa U, Kurtipek GS, Kara F, Kocak M, Erkek E and Caglayan O: Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo. Int J Dermatol. 45:992–993. 2006.PubMed/NCBI View Article : Google Scholar

59 

Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabiani M and Fabbri P: New insights into the pathogenesis of vitiligo: Imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res. 15:87–92. 2002.PubMed/NCBI View Article : Google Scholar

60 

Zailaie MZ: Decreased proinflammatory cytokine production by peripheral blood mononuclear cells from vitiligo patients following aspirin treatment. Saudi Med J. 26:799–805. 2005.PubMed/NCBI

61 

Basak PY, Adiloglu AK, Ceyhan AM, Tas T and Akkaya VB: The role of helper and regulatory T cells in the pathogenesis of vitiligo. J Am Acad Dermatol. 60:256–260. 2009.PubMed/NCBI View Article : Google Scholar

62 

Kemp EH, Emhemad S, Akhtar S, Watson PF, Gawkrodger DJ and Weetman AP: Autoantibodies against tyrosine hydroxylase in patients with non-segmental (generalised) vitiligo. Exp Dermatol. 20:35–40. 2011.PubMed/NCBI View Article : Google Scholar

63 

Barisić-Drusko V and Rucević I: Trigger factors in childhood psoriasis and vitiligo. Coll Antropol. 28:277–285. 2004.PubMed/NCBI

64 

Manolache L and Benea V: Stress in patients with alopecia areata and vitiligo. J Eur Acad Dermatol Venereol. 21:921–928. 2007.PubMed/NCBI View Article : Google Scholar

65 

Papadopoulos L, Bor R, Legg C and Hawk JL: Impact of life events on the onset of vitiligo in adults: Preliminary evidence for a psychological dimension in aetiology. Clin Exp Dermatol. 23:243–248. 1998.PubMed/NCBI View Article : Google Scholar

66 

Picardi A, Pasquini P, Cattaruzza MS, Gaetano P, Melchi CF, Baliva G, Camaioni D, Tiago A, Abeni D and Biondi M: Stressful life events, social support, attachment security and alexithymia in vitiligo. A case-control study. Psychother Psychosom. 72:150–158. 2003.PubMed/NCBI View Article : Google Scholar

67 

Li S, Zhu G, Yang Y, Jian Z, Guo S, Dai W, Shi Q, Ge R, Ma J, Liu L, et al: Oxidative stress drives CD8+ T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes. J Allergy Clin Immunol. 140:177–189.e9. 2017.PubMed/NCBI View Article : Google Scholar

68 

Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS and Amagai M: Pemphigus. Nat Rev Dis Primers. 3(17026)2017.PubMed/NCBI View Article : Google Scholar

69 

Pollmann R, Schmidt T, Eming R and Hertl M: Pemphigus: A comprehensive review on pathogenesis, clinical presentation and novel therapeutic approaches. Clin Rev Allergy Immunol. 54:1–25. 2018.PubMed/NCBI View Article : Google Scholar

70 

Fujimoto M: Regulatory B cells in skin and connective tissue diseases. J Dermatol Sci. 60:1–7. 2010.PubMed/NCBI View Article : Google Scholar

71 

Mauri C and Bosma A: Immune regulatory function of B cells. Annu Rev Immunol. 30:221–241. 2012.PubMed/NCBI View Article : Google Scholar

72 

Inoue M and Shinohara ML: Intracellular osteopontin (iOPN) and immunity. Immunol Res. 49:160–172. 2011.PubMed/NCBI View Article : Google Scholar

73 

Baroni A, De Filippis A, Buommino E, Satriano RA and Cozza V: Osteopontin, a protein with cytokine-like properties: A possible involvement in pemphigus vulgaris. Arch Dermatol Res. 304:237–240. 2012.PubMed/NCBI View Article : Google Scholar

74 

Leung DY and Bieber T: Atopic dermatitis. Lancet. 361:151–160. 2003.PubMed/NCBI View Article : Google Scholar

75 

Spergel JM and Paller AS: Atopic dermatitis and the atopic march. J Allergy Clin Immunol. 112 (Suppl):S118–S127. 2003.PubMed/NCBI View Article : Google Scholar

76 

Leung DY: Infection in atopic dermatitis. Curr Opin Pediatr. 15:399–404. 2003.PubMed/NCBI View Article : Google Scholar

77 

Cho SH, Strickland I, Boguniewicz M and Leung DY: Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin. J Allergy Clin Immunol. 108:269–274. 2001.PubMed/NCBI View Article : Google Scholar

78 

Gallo RL, Murakami M, Ohtake T and Zaiou M: Biology and clinical relevance of naturally occurring antimicrobial peptides. J Allergy Clin Immunol. 110:823–831. 2002.PubMed/NCBI View Article : Google Scholar

79 

Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL and Leung DY: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 347:1151–1160. 2002.PubMed/NCBI View Article : Google Scholar

80 

Ochs RL, Muro Y, Si Y, Ge H, Chan EK and Tan EM: Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol. 105:1211–1220. 2000.PubMed/NCBI View Article : Google Scholar

81 

Seiberler S, Natter S, Hufnagl P, Binder BR and Valenta R: Characterization of IgE-reactive autoantigens in atopic dermatitis. 2. A pilot study on IgE versus IgG subclass response and seasonal variation of IgE autoreactivity. Int Arch Allergy Immunol. 120:117–125. 1999.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Maranduca MA, Hurjui LL, Branisteanu DC, Serban DN, Branisteanu DE, Dima N and Serban IL: Skin ‑ a vast organ with immunological function (Review) . Exp Ther Med 20: 18-23, 2020.
APA
Maranduca, M.A., Hurjui, L.L., Branisteanu, D.C., Serban, D.N., Branisteanu, D.E., Dima, N., & Serban, I.L. (2020). Skin ‑ a vast organ with immunological function (Review) . Experimental and Therapeutic Medicine, 20, 18-23. https://doi.org/10.3892/etm.2020.8619
MLA
Maranduca, M. A., Hurjui, L. L., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Dima, N., Serban, I. L."Skin ‑ a vast organ with immunological function (Review) ". Experimental and Therapeutic Medicine 20.1 (2020): 18-23.
Chicago
Maranduca, M. A., Hurjui, L. L., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Dima, N., Serban, I. L."Skin ‑ a vast organ with immunological function (Review) ". Experimental and Therapeutic Medicine 20, no. 1 (2020): 18-23. https://doi.org/10.3892/etm.2020.8619
Copy and paste a formatted citation
x
Spandidos Publications style
Maranduca MA, Hurjui LL, Branisteanu DC, Serban DN, Branisteanu DE, Dima N and Serban IL: Skin ‑ a vast organ with immunological function (Review) . Exp Ther Med 20: 18-23, 2020.
APA
Maranduca, M.A., Hurjui, L.L., Branisteanu, D.C., Serban, D.N., Branisteanu, D.E., Dima, N., & Serban, I.L. (2020). Skin ‑ a vast organ with immunological function (Review) . Experimental and Therapeutic Medicine, 20, 18-23. https://doi.org/10.3892/etm.2020.8619
MLA
Maranduca, M. A., Hurjui, L. L., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Dima, N., Serban, I. L."Skin ‑ a vast organ with immunological function (Review) ". Experimental and Therapeutic Medicine 20.1 (2020): 18-23.
Chicago
Maranduca, M. A., Hurjui, L. L., Branisteanu, D. C., Serban, D. N., Branisteanu, D. E., Dima, N., Serban, I. L."Skin ‑ a vast organ with immunological function (Review) ". Experimental and Therapeutic Medicine 20, no. 1 (2020): 18-23. https://doi.org/10.3892/etm.2020.8619
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