Open Access

Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease

  • Authors:
    • Wenjie Li
    • Sheng Chen
    • Yuan Luo
    • Yezi Xia
    • Qianqian Ma
    • Qi Yao
    • Jianqing Wu
  • View Affiliations

  • Published online on: May 15, 2020     https://doi.org/10.3892/etm.2020.8758
  • Pages: 1021-1029
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Parkinson's disease (PD) is a chronic progressive disease that affects the central nervous system with a variety of symptoms. Although the precise etiology of PD is not yet fully understood, there is evidence to suggest that T cells serve an important role in the pathogenesis of PD. However, how T cells are recruited in the brain tissue remains to be elucidated. The present study utilized human samples from patients with and without PD to investigate the infiltration of T cells in lesions in the central nervous system. A chemically‑induced mouse PD model was also used to investigate the roles of T cells in the pathogenesis of PD. Depletion of CD4+ or CD8+ T cells was achieved using neutralizing antibodies. Adhesion molecule levels were assessed by flow cytometry. The results of the study indicated that T cell infiltration was evident in both human and murine samples of PD. Blocking CD4+ or CD8+ T cells attenuated the severity of murine PD. Intercellular adhesion molecule 1 (ICAM1 or CD54) was upregulated in mouse PD compared with controls, and its receptor, lymphocyte function‑associated antigen‑1 (LFA1) was overexpressed in T cells of the brain in PD mice compared with controls. Furthermore, inhibition of ICAM1 or LFA1 attenuated PD‑associated characteristics in mice. In conclusion, the interaction between ICAM1 and LFA1 plays a role in recruiting T cells to the central nervous system to mediate experimental PD.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., & Wu, J. (2020). Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease. Experimental and Therapeutic Medicine, 20, 1021-1029. https://doi.org/10.3892/etm.2020.8758
MLA
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., Wu, J."Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease". Experimental and Therapeutic Medicine 20.2 (2020): 1021-1029.
Chicago
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., Wu, J."Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1021-1029. https://doi.org/10.3892/etm.2020.8758