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Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease

  • Authors:
    • Wenjie Li
    • Sheng Chen
    • Yuan Luo
    • Yezi Xia
    • Qianqian Ma
    • Qi Yao
    • Jianqing Wu
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Jiangsu Provincial Key Laboratory of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Nephrology, Ningbo Medical Center Lihuili Hospital, Ningbo, Zheijiang 315000, P.R. China, Department of Geriatrics, Ningbo First Hospital, Ningbo, Zheijiang 315000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1021-1029
    |
    Published online on: May 15, 2020
       https://doi.org/10.3892/etm.2020.8758
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Abstract

Parkinson's disease (PD) is a chronic progressive disease that affects the central nervous system with a variety of symptoms. Although the precise etiology of PD is not yet fully understood, there is evidence to suggest that T cells serve an important role in the pathogenesis of PD. However, how T cells are recruited in the brain tissue remains to be elucidated. The present study utilized human samples from patients with and without PD to investigate the infiltration of T cells in lesions in the central nervous system. A chemically‑induced mouse PD model was also used to investigate the roles of T cells in the pathogenesis of PD. Depletion of CD4+ or CD8+ T cells was achieved using neutralizing antibodies. Adhesion molecule levels were assessed by flow cytometry. The results of the study indicated that T cell infiltration was evident in both human and murine samples of PD. Blocking CD4+ or CD8+ T cells attenuated the severity of murine PD. Intercellular adhesion molecule 1 (ICAM1 or CD54) was upregulated in mouse PD compared with controls, and its receptor, lymphocyte function‑associated antigen‑1 (LFA1) was overexpressed in T cells of the brain in PD mice compared with controls. Furthermore, inhibition of ICAM1 or LFA1 attenuated PD‑associated characteristics in mice. In conclusion, the interaction between ICAM1 and LFA1 plays a role in recruiting T cells to the central nervous system to mediate experimental PD.
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1 

Jankovic J: Parkinson's disease: Clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 79:368–376. 2008.PubMed/NCBI View Article : Google Scholar

2 

Noorian AR, Rha J, Annerino DM, Bernhard D, Taylor GM and Greene JG: Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system. Neurobiol Dis. 48:9–19. 2012.PubMed/NCBI View Article : Google Scholar

3 

Chaudhuri KR and Schapira AH: Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment. Lancet Neurol. 8:464–474. 2009.PubMed/NCBI View Article : Google Scholar

4 

Magerkurth C, Schnitzer R and Braune S: Symptoms of autonomic failure in Parkinson's disease: Prevalence and impact on daily life. Clin Auton Res. 15:76–82. 2005.PubMed/NCBI View Article : Google Scholar

5 

Fasano M and Lopiano L: Alpha-synuclein and Parkinson's disease: A proteomic view. Expert Rev Proteomics. 5:239–248. 2008.PubMed/NCBI View Article : Google Scholar

6 

Tofaris GK, Razzaq A, Ghetti B, Lilley KS and Spillantini MG: Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J Biol Chem. 278:44405–44411. 2003.PubMed/NCBI View Article : Google Scholar

7 

Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R and Goedert M: Alpha-synuclein in Lewy bodies. Nature. 388:839–880. 1997.PubMed/NCBI View Article : Google Scholar

8 

Tansey MG, McCoy MK and Frank-Cannon TC: Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol. 208:1–25. 2007.PubMed/NCBI View Article : Google Scholar

9 

Saunders JA, Estes KA, Kosloski LM, Allen HE, Dempsey KM, Torres-Russotto DR, Meza JL, Santamaria PM, Bertoni JM, Murman DL, et al: CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease. J Neuroimmune Pharmacol. 7:927–938. 2012.PubMed/NCBI View Article : Google Scholar

10 

Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, et al: Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest. 119:182–192. 2009.PubMed/NCBI View Article : Google Scholar

11 

Jiang L, Hu J, Feng J, Han D and Yang C: Substrate stiffness of endothelial cells directs LFA-1/ICAM-1 interaction: A physical trigger of immune-related diseases? Clin Hemorheol Microcirc. 61:633–643. 2016.PubMed/NCBI View Article : Google Scholar

12 

Harrer A, Pilz G, Wipfler P, Oppermann K, Sellner J, Hitzl W, Haschke-Becher E, Afazel S, Rispens T, van der Kleij D, et al: High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis. Clin Exp Immunol. 180:383–392. 2015.PubMed/NCBI View Article : Google Scholar

13 

Dickson DW: Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med. 2(a009258)2012.PubMed/NCBI View Article : Google Scholar

14 

Meredith GE and Rademacher DJ: MPTP mouse models of Parkinson's disease: An update. J Parkinsons Dis. 1:19–33. 2011.PubMed/NCBI View Article : Google Scholar

15 

Luchtman DW, Shao D and Song C: Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease. Physiol Behav. 98:130–138. 2009.PubMed/NCBI View Article : Google Scholar

16 

Deacon RM, Koros E, Bornemann KD and Rawlins JN: Aged Tg2576 mice are impaired on social memory and open field habituation tests. Behav Brain Res. 197:466–468. 2009.PubMed/NCBI View Article : Google Scholar

17 

Chandra G, Rangasamy SB, Roy A, Kordower JH and Pahan K: Neutralization of RANTES and eotaxin prevents the loss of dopaminergic neurons in a mouse model of parkinson disease. J Biol Chem. 291:15267–15281. 2016.PubMed/NCBI View Article : Google Scholar

18 

Krummel MF, Bartumeus F and Gérard A: T cell migration, search strategies and mechanisms. Nat Rev Immunol. 16:193–201. 2016.PubMed/NCBI View Article : Google Scholar

19 

Walling BL and Kim M: LFA-1 in T cell migration and differentiation. Front Immunol. 9(952)2018.PubMed/NCBI View Article : Google Scholar

20 

Miklossy J, Doudet DD, Schwab C, Yu S, McGeer EG and McGeer PL: Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Exp Neurol. 197:275–283. 2006.PubMed/NCBI View Article : Google Scholar

21 

Rivera-Nieves J, Gorfu G and Ley K: Leukocyte adhesion molecules in animal models of inflammatory bowel disease. Inflamm Bowel Dis. 14:1715–1735. 2008.PubMed/NCBI View Article : Google Scholar

22 

Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, et al: Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 139:485–498. 2009.PubMed/NCBI View Article : Google Scholar

23 

Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB and Littman DR: Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 4:337–349. 2008.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li W, Chen S, Luo Y, Xia Y, Ma Q, Yao Q and Wu J: Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease. Exp Ther Med 20: 1021-1029, 2020.
APA
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., & Wu, J. (2020). Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease. Experimental and Therapeutic Medicine, 20, 1021-1029. https://doi.org/10.3892/etm.2020.8758
MLA
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., Wu, J."Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease". Experimental and Therapeutic Medicine 20.2 (2020): 1021-1029.
Chicago
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., Wu, J."Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1021-1029. https://doi.org/10.3892/etm.2020.8758
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Chen S, Luo Y, Xia Y, Ma Q, Yao Q and Wu J: Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease. Exp Ther Med 20: 1021-1029, 2020.
APA
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., & Wu, J. (2020). Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease. Experimental and Therapeutic Medicine, 20, 1021-1029. https://doi.org/10.3892/etm.2020.8758
MLA
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., Wu, J."Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease". Experimental and Therapeutic Medicine 20.2 (2020): 1021-1029.
Chicago
Li, W., Chen, S., Luo, Y., Xia, Y., Ma, Q., Yao, Q., Wu, J."Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1021-1029. https://doi.org/10.3892/etm.2020.8758
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