Open Access

Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: A case report

  • Authors:
    • Xuejiao Zhang
    • Baofeng Xu
    • Ziwei Liu
    • Yuanyuan Gao
    • Qing Wang
    • Rui Liu
  • View Affiliations

  • Published online on: May 25, 2020     https://doi.org/10.3892/etm.2020.8788
  • Pages: 996-1002
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease and hypothyroidism is an organ‑specific autoimmune disease. The two diseases may occur successively or simultaneously. The majority of previous studies observed that thyroid disease was more frequent in patients with SLE than in the general population, particularly those who had a higher incidence of anti‑thyroid antibodies. However, there are no reported cases of SLE with hypothyroidism as the initial clinical manifestation, to the best of our knowledge. The present study reported on a case of SLE with this unusual initial clinical manifestation and reviewed the literature to estimate the prevalence of clinical hypothyroidism in patients with SLE (range, 3.0‑21.4%). The case of the present study had no obvious facial erythema, photosensitivity or recurrent oral ulcers, and only had hypothyroidism as the initial clinical symptom, but the laboratory examination supported the diagnosis of SLE. The present study suggested that in the clinical diagnosis, attention should be paid to screening for connective tissue diseases when diagnosing hypothyroidism, and the importance of thyroid dysfunction should also be recognized in the treatment of SLE.

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August-2020
Volume 20 Issue 2

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Online ISSN:1792-1015

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APA
Zhang, X., Xu, B., Liu, Z., Gao, Y., Wang, Q., & Liu, R. (2020). Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: A case report. Experimental and Therapeutic Medicine, 20, 996-1002. https://doi.org/10.3892/etm.2020.8788
MLA
Zhang, X., Xu, B., Liu, Z., Gao, Y., Wang, Q., Liu, R."Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: A case report". Experimental and Therapeutic Medicine 20.2 (2020): 996-1002.
Chicago
Zhang, X., Xu, B., Liu, Z., Gao, Y., Wang, Q., Liu, R."Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: A case report". Experimental and Therapeutic Medicine 20, no. 2 (2020): 996-1002. https://doi.org/10.3892/etm.2020.8788