Open Access

Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure

  • Authors:
    • Jin‑Bo Zhang
    • Jin‑Qiang Zhu
    • Lie‑Xiang Cao
    • Xiao‑Hong Jin
    • Li‑Li Chen
    • Yu‑Kang Song
    • Shi‑Fang Zhou
    • Ji‑Hong Ma
    • Hui Fu
    • Jin‑Zhong Xu
    • Mei‑Ping Dong
    • Lai‑Chao Yan
    • Xian‑Dan Wu
    • Hui‑Ping Wang
    • Jun‑Yang Zhou
    • Yan‑Qiu Wang
  • View Affiliations

  • Published online on: June 12, 2020     https://doi.org/10.3892/etm.2020.8884
  • Pages: 1441-1446
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sequential invasive-noninvasive ventilation (NIV) improves the outcomes of patients with respiratory failure caused by acute exacerbation of chronic obstructive pulmonary disease (AECOPD); however, there is no clear consensus on the optimal timing of the switch to sequential invasive‑NIV in these patients. In the present study, a potential role for the modified Glasgow Coma Scale (GCS) score to guide sequential weaning was investigated. Patients with AECOPD and respiratory failure were prospectively recruited from three study centers (Wenling Hospital Affiliated to Wenzhou Medical University, the First Affiliated Hospital of Wenzhou Medical University and Changsha Central Hospital) between January 1st 2016 and December 31st 2018. Patients were randomly assigned to group A and B, with the switching point for sequential weaning strategy in the two groups being a modified GCS score ≥13 and 10 points, respectively. Each group included 240 patients. Baseline demographic characteristics were comparable in the two groups. The duration of invasive mechanical ventilation (IMV) in group A was significantly shorter than that in group B. However, there were no significant between‑group differences with respect to the incidence of re‑intubation, ventilator‑associated pneumonia, in‑hospital mortality or the length of hospital stay. Use of a modified GCS score ≥13 as the switching point for sequential invasive‑NIV may help decrease the duration of IMV in patients with AECOPD and respiratory failure.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y. ... Wang, Y. (2020). Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure. Experimental and Therapeutic Medicine, 20, 1441-1446. https://doi.org/10.3892/etm.2020.8884
MLA
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y., Zhou, S., Ma, J., Fu, H., Xu, J., Dong, M., Yan, L., Wu, X., Wang, H., Zhou, J., Wang, Y."Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure". Experimental and Therapeutic Medicine 20.2 (2020): 1441-1446.
Chicago
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y., Zhou, S., Ma, J., Fu, H., Xu, J., Dong, M., Yan, L., Wu, X., Wang, H., Zhou, J., Wang, Y."Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1441-1446. https://doi.org/10.3892/etm.2020.8884