|
1
|
Childs BG, Durik M, Baker DJ and van
Deursen JM: Cellular senescence in aging and age-related disease:
From mechanisms to therapy. Nat Med. 21:1424–1435. 2015.PubMed/NCBI View
Article : Google Scholar
|
|
2
|
Muñoz-Espín D and Serrano M: Cellular
senescence: From physiology to pathology. Nat Rev Mol Cell Biol.
15:482–496. 2014.PubMed/NCBI View
Article : Google Scholar
|
|
3
|
Dimri GP, Lee X, Basile G, Acosta M, Scott
G, Roskelley C, Medrano EE, Linskens M, Rubelj I and Pereira-Smith
O: A biomarker that identifies senescent human cells in culture and
in aging skin in vivo. Proc Natl Acad Sci USA. 92:9363–9367.
1995.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Tchkonia T, Zhu Y, van Deursen J, Campisi
J and Kirkland JL: Cellular senescence and the senescent secretory
phenotype: Therapeutic opportunities. J Clin Invest. 123:966–972.
2013.PubMed/NCBI View
Article : Google Scholar
|
|
5
|
Hall BM, Balan V, Gleiberman AS, Strom E,
Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin I, et
al: Aging of mice is associated with p16(Ink4a)- and
β-galactosidase-positive macrophage accumulation that can be
induced in young mice by senescent cells. Aging (Albany NY).
8:1294–1315. 2016.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Kenyon C: The first long-lived mutants:
Discovery of the insulin/IGF-1 pathway for ageing. Philos Trans R
Soc Lond B Biol Sci. 366:9–16. 2011.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Lee C, Wan J, Miyazaki B, Fang Y,
Guevara-Aguirre J, Yen K, Longo V, Bartke A and Cohen P: IGF-I
regulates the age-dependent signaling peptide humanin. Aging Cell.
13:958–961. 2014.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Salmon WD Jr and Daughaday WH: A
hormonally controlled serum factor which stimulates sulfate
incorporation by cartilage in vitro. 1956. J Lab Clin Med.
116:408–419. 1990.PubMed/NCBI
|
|
9
|
Rinderknecht E and Humbel RE: The amino
acid sequence of human insulin-like growth factor I and its
structural homology with proinsulin. J Biol Chem. 253:2769–2776.
1978.PubMed/NCBI
|
|
10
|
Daughaday WH, Hall K, Raben MS, Salmon WD
Jr, van den Brande JL and van Wyk JJ: Somatomedin: Proposed
designation for sulphation factor. Nature. 235(107)1972.PubMed/NCBI View
Article : Google Scholar
|
|
11
|
Powell-Braxton L, Hollingshead P,
Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N and Stewart
TA: IGF-I is required for normal embryonic growth in mice. Genes
Dev. 7:2609–2617. 1993.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Costales J and Kolevzon A: The therapeutic
potential of insulin-like growth factor-1 in central nervous system
disorders. Neurosci Biobehav Rev. 63:207–122. 2016.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Castilla-Cortazar I, Guerra L, Puche JE,
Muñoz U, Barhoum R, Escudero E and Lavandera JL: An experimental
model of partial insulin-like growth factor-1 deficiency in mice. J
Physiol Biochem. 70:129–139. 2014.PubMed/NCBI View Article : Google Scholar
|
|
14
|
De Ita JR, Castilla-Cortázar I, Aguirre
GA, Sánchez-Yago C, Santos-Ruiz MO, Guerra-Menéndez L, Martín-Estal
I, García-Magariño M, Lara-Díaz VJ, Puche JE and Muñoz U: Altered
liver expression of genes involved in lipid and glucose metabolism
in mice with partial IGF-1 deficiency: An experimental approach to
metabolic syndrome. J Transl Med. 13(326)2015.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Nishizawa H, Iguchi G, Fukuoka H,
Takahashi M, Suda K, Bando H, Matsumoto R, Yoshida K, Odake Y,
Ogawa W and Takahashi Y: IGF-I induces senescence of hepatic
stellate cells and limits fibrosis in a p53-dependent manner. Sci
Rep. 6(34605)2016.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Xu J, Gontier G, Chaker Z, Lacube P,
Dupont J and Holzenberger M: Longevity effect of IGF-1R(+/-)
mutation depends on genetic background-specific receptor
activation. Aging Cell. 13:19–28. 2014.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Di Bona D, Accardi G, Virruso C, Candore G
and Caruso C: Association of Klotho polymorphisms with healthy
aging: A systematic review and meta-analysis. Rejuvenation Res.
17:212–216. 2014.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Lotz M and Loeser RF: Effects of aging on
articular cartilage homeostasis. Bone. 51:241–248. 2012.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Price JS, Waters JG, Darrah C, Pennington
C, Edwards DR, Donell ST and Clark IM: The role of chondrocyte
senescence in osteoarthritis. Aging Cell. 1:57–65. 2002.PubMed/NCBI View Article : Google Scholar
|
|
20
|
McCulloch K, Litherland GJ and Rai TS:
Cellular senescence in osteoarthritis pathology. Aging Cell.
16:210–218. 2017.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Handayaningsih AE, Takahashi M, Fukuoka H,
Iguchi G, Nishizawa H, Yamamoto M, Suda K and Takahashi Y: IGF-I
enhances cellular senescence via the reactive oxygen species-p53
pathway. Biochem Biophys Res Commun. 425:478–484. 2012.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Tran D, Bergholz J, Zhang HB, He HB, Wang
Y, Zhang YJ, Li QT, Kirkland JL and Xiao ZX: Insulin-like growth
factor-1 regulates the SIRT1-p53 pathway in cellular senescence.
Aging Cell. 13:669–678. 2014.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Zhang M, Zhou Q, Liang QQ, Li CG, Holz JD,
Tang D, Sheu TJ, Li TF, Shi Q and Wang YJ: IGF-1 regulation of type
II collagen and MMP-13 expression in rat endplate chondrocytes via
distinct signaling pathways. Osteoarthritis Cartilage. 17:100–106.
2009.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim
HS, Jo D, Abel ED, Lee TJ and Kim J: Deletion of IGF-1 receptors in
cardiomyocytes attenuates cardiac aging in male mice.
Endocrinology. 157:336–345. 2016.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Starkman BG, Cravero JD, Delcarlo M and
Loeser RF: IGF-I stimulation of proteoglycan synthesis by
chondrocytes requires activation of the PI 3-kinase pathway but not
ERK MAPK. Biochem J. 389:723–729. 2005.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Kulik G and Weber MJ: Akt-dependent and
-independent survival signaling pathways utilized by insulin-like
growth factor I. Mol Cell Biol. 18:6711–6718. 1998.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Panganiban RAM and Day RM: Inhibition of
IGF-1R prevents ionizing radiation-induced primary endothelial cell
senescence. PLoS One. 8(e78589)2013.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Xu XX, Zhang XH, Diao Y and Huang YX:
Achyranthes bidentate saponins protect rat articular chondrocytes
against interleukin-1β induced inflammation and apoptosis in vitro.
Kaohsiung J Med Sci. 33:62–68. 2017.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Jiang CS, Liu G, Luckhardt T, Antony V,
Zhou Y, Carter AB, Thannickal VJ and Liu RM: Serpine 1 induces
alveolar type II cell senescence through activating p53-p21-Rb
pathway in fibrotic lung disease. Aging Cell. 16:1114–1124.
2017.PubMed/NCBI View Article : Google Scholar
|
|
31
|
el-Deiry WS, Tokino T, Velculescu VE, Levy
DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and
Vogelstein B: WAF1, a potential mediator of p53 tumor suppression.
Cell. 75:817–825. 1993.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Choi J, Shendrik I, Peacocke M, Peehl D,
Buttyan R, Ikeguchi EF, Katz AE and Benson MC: Expression of
senescence-associated beta-galactosidase in enlarged prostates from
men with benign prostatic hyperplasia. Urology. 56:160–166.
2000.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Kurz DJ, Decary S, Hong Y and Erusalimsky
JD: Senescence-associated (beta)-galactosidase reflects an increase
in lysosomal mass during replicative ageing of human endothelial
cells. J Cell Sci. 113:3613–3622. 2000.PubMed/NCBI
|
|
34
|
Loeser RF: Aging and osteoarthritis: The
role of chondrocyte senescence and aging changes in the cartilage
matrix. Osteoarthritis Cartilage. 17:971–979. 2009.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Liu ZM, Shen PC, Lu CC, Chou SH and Tien
YC: Characterization of the proliferating layer chondrocytes of
growth plate for cartilage regeneration. Tissue Eng Part A.
25:364–378. 2019.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Kang SW, Yoo SP and Kim BS: Effect of
chondrocyte passage number on histological aspects of
tissue-engineered cartilage. Biomed Mater Eng. 5:269–276.
2007.PubMed/NCBI
|
|
37
|
Handayaningsih AE, Iguchi G, Fukuoka H,
Nishizawa H, Takahashi M, Yamamoto M, Herningtyas EH, Okimura Y,
Kaji H, Chihara K, et al: Reactive oxygen species play an essential
role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in
C2C12 myocytes. Endocrinology. 152:912–921. 2011.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Itahana K, Dimri G and Campisi J:
Regulation of cellular senescence by p53. Eur J Biochem.
268:2784–2791. 2001.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Atadja P, Wong H, Garkavtsev I, Veillette
C and Riabowol K: Increased activity of p53 in senescing
fibroblasts. Proc Natl Acad Sci USA. 92:8348–8352. 1995.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Wang Z, Rong X, Luo B, Qin S, Lu L, Zhang
X, Sun Y, Hu Q and Zhang C: A natural model of mouse cardiac
myocyte senescence. J Cardiovasc Transl Res. 9:456–458.
2016.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Jackson JG and Pereira-Smith OM: p53 is
preferentially recruited to the promoters of growth arrest genes
p21 and GADD45 during replicative senescence of normal human
fibroblasts. Cancer Res. 66:8356–8360. 2006.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Herbig U, Jobling WA, Chen BP, Chen DJ and
Sedivy JM: Telomere shortening triggers senescence of human cells
through a pathway involving ATM, p53, and p21(CIP1), but not
p16(INK4a). Mol Cell. 14:501–513. 2004.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Dimri GP, Testori A, Acosta M and Campisi
J: Replicative senescence, aging and growth-regulatory
transcription factors. Biol Signals. 5:154–162. 1996.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Chen ZB, Trotman LC, Shaffer D, Lin HK,
Dotan Z, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, et al:
Crucial role of p53-dependent cellular senescence in suppression of
Pten-deficient tumorigenesis. Nature. 436:725–730. 2005.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Blume-Jensen P and Hunter T: Oncogenic
kinase signalling. Nature. 411:355–365. 2001.PubMed/NCBI View Article : Google Scholar
|
