Open Access

Engineered Akkermansia muciniphila: A promising agent against diseases (Review)

  • Authors:
    • Yixuan Zou
    • Tingtao Chen
  • View Affiliations

  • Published online on: October 29, 2020     https://doi.org/10.3892/etm.2020.9415
  • Article Number: 285
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Achieving a harmonious gut microbial ecosystem has been hypothesized to be a successful method for alleviating metabolic disorders. The administration of probiotics, such as Lactobacillus and Bifidobacteria, is a known traditional and safe pathway to regulate human commensal microbes. With advancements in genetic sequencing and genetic editing tools, more bacteria are able to function as engineered probiotics with multiple therapeutic properties. As one of the next‑generation probiotic candidates, Akkermansia muciniphila (A. muciniphila) has been discovered to enhance the gut barrier function and moderate inflammatory responses, exhibit improved effects with pasteurization and display beneficial probiotic effects in individuals with obesity, type 2 diabetes, atherosclerosis and autism‑related gastrointestinal disturbances. In view of this knowledge, the present review aimed to summarize the effects of A. muciniphila in the treatment of metabolic disorders and to discuss several mature recombination systems for the genetic modification of A. muciniphila. From gaining an enhanced understanding of its genetic background, ingested A. muciniphila is expected to be used in various applications, including as a diagnostic tool, and in the site‑specific delivery of therapeutic drugs.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zou Y and Zou Y: Engineered <em>Akkermansia muciniphila</em>: A promising agent against diseases (Review). Exp Ther Med 20: 285, 2020
APA
Zou, Y., & Zou, Y. (2020). Engineered <em>Akkermansia muciniphila</em>: A promising agent against diseases (Review). Experimental and Therapeutic Medicine, 20, 285. https://doi.org/10.3892/etm.2020.9415
MLA
Zou, Y., Chen, T."Engineered <em>Akkermansia muciniphila</em>: A promising agent against diseases (Review)". Experimental and Therapeutic Medicine 20.6 (2020): 285.
Chicago
Zou, Y., Chen, T."Engineered <em>Akkermansia muciniphila</em>: A promising agent against diseases (Review)". Experimental and Therapeutic Medicine 20, no. 6 (2020): 285. https://doi.org/10.3892/etm.2020.9415