Open Access

Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells

  • Authors:
    • Tingting Wang
    • Wonmin Ko
    • Joon-Yeong Shin
    • Dongho Choi
    • Dong-Sung Lee
    • Sungchul Kim
  • View Affiliations

  • Published online on: April 8, 2021     https://doi.org/10.3892/etm.2021.10023
  • Article Number: 591
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mecasin, a traditional medicine, contains nine herbal constituents: Curcuma longa, Salvia miltio rhiza, Gastrodia elata, Chaenomeles sinensis, Polygala tenuifolia, Paeonia japonica, Glycyrrhiza uralensis, Atractylodes japonica and processed Aconitum carmichaeli. Several biological effects of mecasin have been described both in vivo and in vitro. Previous studies have demonstrated that mecasin has anti‑inflammatory effects. The purpose of the present study was to determine anti‑inflammatory effects of mecasin and its natural product constituents on lipopolysaccharide (LPS)‑stimulated BV2 cells by measuring nitrite and nitric oxide contents. Nitrite production levels in LPS‑stimulated BV2 cells incubated with mecasin and each individual constituent of mecasin were measured. The results suggested that C. longa, P. tenuifolia and P. japonica inhibited nitrite production in a pattern similar to that of mecasin. The effect of mecasin was likely a result of synergistic effects of its natural herb constituents.
View Figures
View References

Related Articles

Journal Cover

June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Ko W, Shin J, Choi D, Lee D and Kim S: Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells. Exp Ther Med 21: 591, 2021
APA
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., & Kim, S. (2021). Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells. Experimental and Therapeutic Medicine, 21, 591. https://doi.org/10.3892/etm.2021.10023
MLA
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., Kim, S."Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells". Experimental and Therapeutic Medicine 21.6 (2021): 591.
Chicago
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., Kim, S."Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells". Experimental and Therapeutic Medicine 21, no. 6 (2021): 591. https://doi.org/10.3892/etm.2021.10023