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Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells

  • Authors:
    • Tingting Wang
    • Wonmin Ko
    • Joon-Yeong Shin
    • Dongho Choi
    • Dong-Sung Lee
    • Sungchul Kim
  • View Affiliations / Copyright

    Affiliations: ALS/MND Center of Wonkwang University Gwangju Korean Medicine Hospital, Gwangju 61729, Republic of Korea, Department of Pharmacy, Chosun University, Dong‑gu, Gwangju 61452, Republic of Korea, Professional Graduate School, Wonkwang University, Jeonbuk, Iksan 54538, Republic of Korea
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 591
    |
    Published online on: April 8, 2021
       https://doi.org/10.3892/etm.2021.10023
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Abstract

Mecasin, a traditional medicine, contains nine herbal constituents: Curcuma longa, Salvia miltio rhiza, Gastrodia elata, Chaenomeles sinensis, Polygala tenuifolia, Paeonia japonica, Glycyrrhiza uralensis, Atractylodes japonica and processed Aconitum carmichaeli. Several biological effects of mecasin have been described both in vivo and in vitro. Previous studies have demonstrated that mecasin has anti‑inflammatory effects. The purpose of the present study was to determine anti‑inflammatory effects of mecasin and its natural product constituents on lipopolysaccharide (LPS)‑stimulated BV2 cells by measuring nitrite and nitric oxide contents. Nitrite production levels in LPS‑stimulated BV2 cells incubated with mecasin and each individual constituent of mecasin were measured. The results suggested that C. longa, P. tenuifolia and P. japonica inhibited nitrite production in a pattern similar to that of mecasin. The effect of mecasin was likely a result of synergistic effects of its natural herb constituents.
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Copy and paste a formatted citation
Spandidos Publications style
Wang T, Ko W, Shin J, Choi D, Lee D and Kim S: Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells. Exp Ther Med 21: 591, 2021.
APA
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., & Kim, S. (2021). Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells. Experimental and Therapeutic Medicine, 21, 591. https://doi.org/10.3892/etm.2021.10023
MLA
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., Kim, S."Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells". Experimental and Therapeutic Medicine 21.6 (2021): 591.
Chicago
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., Kim, S."Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells". Experimental and Therapeutic Medicine 21, no. 6 (2021): 591. https://doi.org/10.3892/etm.2021.10023
Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Ko W, Shin J, Choi D, Lee D and Kim S: Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells. Exp Ther Med 21: 591, 2021.
APA
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., & Kim, S. (2021). Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells. Experimental and Therapeutic Medicine, 21, 591. https://doi.org/10.3892/etm.2021.10023
MLA
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., Kim, S."Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells". Experimental and Therapeutic Medicine 21.6 (2021): 591.
Chicago
Wang, T., Ko, W., Shin, J., Choi, D., Lee, D., Kim, S."Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells". Experimental and Therapeutic Medicine 21, no. 6 (2021): 591. https://doi.org/10.3892/etm.2021.10023
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