Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy

  • Authors:
    • Fengwei Li
    • Zhenjian Zhan
    • Jin Qian
    • Chuanbin Cao
    • Wei Yao
    • Neng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei 441300, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 811
    |
    Published online on: May 28, 2021
       https://doi.org/10.3892/etm.2021.10243
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Naringin (NRG) has been reported to exert cardioprotective effects against multiple cardiovascular diseases, including lipopolysaccharide‑induced and hyperglycemia‑induced myocardial injury. However, the role of NRG in myocardial ischemia/reperfusion (I/R) injury remains unclear. In the present study, the PI3K/Akt pathway was investigated to evaluate the possible mechanisms underlying the roles of NRG in myocardial ischemia/reperfusion (I/R) injury. The levels of cardiac enzymes were measured by ELISA to evaluate the optimal dosage of NRG that could protect against myocardial I/R injury. Rats were administered 100 mg/kg of NRG and activities of myocardial enzymes, the level of cardiac apoptosis and inflammation, oxidant response, autophagy indicators and echocardiography were evaluated. The level of corresponding proteins was measured using western blotting. The results indicated that NRG elicited the best cardioprotective effects at a dose of 100 mg/kg by significantly reducing the levels of myocardial enzymes, apoptosis, inflammation, oxidative response and infarct size. Furthermore, NRG alleviated contractile dysfunction by increasing the left ventricular ejection fraction and fractional shortening. In addition, NRG markedly promoted the phosphorylation of Akt, while decreasing the level of autophagy indicator beclin‑1 and the microtubule‑associated protein 1B‑light chain 3 (LC3B) II/ LC3BI ratio. However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin‑1, along with the LC3BII/LC3BI ratio. The results of the present study demonstrated that NRG could attenuate myocardial I/R injury.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Heusch G and Gersh BJ: The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: A continual challenge. Eur Heart J. 38:774–784. 2017.PubMed/NCBI View Article : Google Scholar

2 

Wang BF and Yoshioka J: The emerging role of thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury. J Cardiovasc Pharmacol Ther. 22:219–229. 2017.PubMed/NCBI View Article : Google Scholar

3 

Wang P, Sun J, Lv S, Xie T and Wang X: Apigenin alleviates myocardial reperfusion injury in rats by downregulating miR-15b. Med Sci Monit. 25:2764–2776. 2019.PubMed/NCBI View Article : Google Scholar

4 

Shen Y, Liu X, Shi J and Wu X: Involvement of Nrf2 in myocardial ischemia and reperfusion injury. Int J Biol Macromol. 125:496–502. 2019.PubMed/NCBI View Article : Google Scholar

5 

Jian CY, Ouyang HB, Xiang XH, Chen JL, Li YX, Zhou X, Wang JY, Yang Y, Zhong EY, Huang WH, et al: Naringin protects myocardial cells from doxorubicin induced apoptosis partially by inhibiting the p38MAPK pathway. Mol Med Rep. 16:9457–9463. 2017.PubMed/NCBI View Article : Google Scholar

6 

Chen RC, Sun GB, Wang J, Zhang HJ and Sun XB: Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. Food Funct. 6:1331–1344. 2015.PubMed/NCBI View Article : Google Scholar

7 

Xianchu L, Lan PZ, Qiufang L, Yi L, Xiangcheng R, Wenqi H and Yang D: Naringin protects against lipopolysaccharide-induced cardiac injury in mice. Environ Toxicol Pharmacol. 48:1–6. 2016.PubMed/NCBI View Article : Google Scholar

8 

Li YP, Chen Z and Cai YH: Piperine protects against myocardial ischemia/reperfusion injury by activating the PI3K/AKT signaling pathway. Exp Ther Med. 21(374)2021.PubMed/NCBI View Article : Google Scholar

9 

Zeng B, Liu L, Liao X, Zhang C and Ruan H: Thyroid hormone protects cardiomyocytes from H2O2-induced oxidative stress via the PI3K-AKT signaling pathway. Exp Cell Res. 380:205–215. 2019.PubMed/NCBI View Article : Google Scholar

10 

Shaker ME, Ashamallah SA and Houssen ME: Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis. Chem Biol Interact. 210:26–33. 2014.PubMed/NCBI View Article : Google Scholar

11 

Wu S, Chang G, Gao L, Jiang D, Wang L, Li G, Luo X, Qin S, Guo X and Zhang D: Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy. J Mol Med (Berl). 96:791–806. 2018.PubMed/NCBI View Article : Google Scholar

12 

Ye G, Fu Q, Jiang L and Li Z: Vascular smooth muscle cells activate PI3K/Akt pathway to attenuate myocardial ischemia/reperfusion-induced apoptosis and autophagy by secreting bFGF. Biomed Pharmacother. 107:1779–1785. 2018.PubMed/NCBI View Article : Google Scholar

13 

Rani N, Bharti S, Manchanda M, Nag TC, Ray R, Chauhan SS, Kumari S and Arya DS: Regulation of heat shock proteins 27 and 70, p-Akt/p-eNOS and MAPKs by Naringin Dampens myocardial injury and dysfunction in vivo after ischemia/reperfusion. PLoS One. 8(e82577)2013.PubMed/NCBI View Article : Google Scholar

14 

Sherry EV: Review of the third edition of the Guide for the Care and Use of Agricultural Animals in Research and Teaching. J Am Assoc Lab Anim Sci. 51(3)(298 300)2012.PubMed/NCBI

15 

Cerkezkayabekir A, Sanal F, Bakar E, Ulucam E and Inan M: Naringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat model. Biotech Histochem. 92:252–263. 2017.PubMed/NCBI View Article : Google Scholar

16 

Jiang X, Kong B, Shuai W, Shen C, Yang F, Fu H, Huang H, Jiang X, Kong B, Shuai W, et al: Loss of MD1 exacerbates myocardial ischemia/reperfusion injury and susceptibility to ventricular arrhythmia. Eur J Pharmacol. 844:79–86. 2019.PubMed/NCBI View Article : Google Scholar

17 

Lee JC and Sponenberg DP: Role of alpha 1-adrenoceptors in norepinephrine-induced cardiomyopathy. Am J Pathol. 121:316–321. 1985.PubMed/NCBI

18 

Sepúlveda M, Gonano LA, Viotti M, Morell M, Blanco P, López Alarcón M, Peroba Ramos I, Bastos Carvalho A, Medei E and Vila Petroff M: Calcium/Calmodulin protein kinase II-dependent ryanodine receptor phosphorylation mediates cardiac contractile dysfunction associated with sepsis. Crit Care Med. 45:e399–e408. 2017.PubMed/NCBI View Article : Google Scholar

19 

Wang N, Zheng X, Qian J, Yao W, Bai L, Hou G, Qiu X, Li X and Jiang X: Renal sympathetic denervation alleviates myocardial fibrosis following isoproterenol-induced heart failure. Mol Med Rep. 16:5091–5098. 2017.PubMed/NCBI View Article : Google Scholar

20 

Tong S, Zhang L, Joseph J and Jiang X: Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway. Biochem Biophys Res Commun. 497:843–849. 2018.PubMed/NCBI View Article : Google Scholar

21 

Rajadurai M and Prince PS: Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. Phytother Res. 23:358–362. 2009.PubMed/NCBI View Article : Google Scholar

22 

Li W, Wang C, Peng J, Liang J, Jin Y, Liu Q, Meng Q, Liu K and Sun H: Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κB and PI3K/Akt pathways. Curr Pharm Biotechnol. 15:1173–1182. 2014.PubMed/NCBI View Article : Google Scholar

23 

Wu Q, Lu K, Zhao Z, Wang B, Liu H, Zhang S, Liao J, Zeng Y, Dong Q, Zhao N, et al: Blockade of transient receptor potential vanilloid 4 enhances antioxidation after myocardial ischemia/reperfusion. Oxid Med Cell Longev. 2019(7283683)2019.PubMed/NCBI View Article : Google Scholar

24 

Liu Z, Tao B, Fan S, Pu Y, Xia H and Xu L: MicroRNA 145 protects against myocardial ischemia reperfusion injury via CaMKII mediated anti apoptotic and anti inflammatory pathways. Oxid Med Cell Longev. 2019(8948657)2019.PubMed/NCBI View Article : Google Scholar

25 

Dong J, Xu M, Zhang W and Che X: Effects of sevoflurane pretreatment on myocardial ischemia-reperfusion injury through the Akt/hypoxia-inducible factor 1-alpha (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway. Med Sci Monit. 25:3100–3107. 2019.PubMed/NCBI View Article : Google Scholar

26 

Yang P, Zhou Y, Xia Q, Yao L and Chang X: Astragaloside IV regulates the PI3K/Akt/HO-1 signaling pathway and inhibits H9c2 cardiomyocyte injury induced by hypoxia-reoxygenation. Biol Pharm Bull. 42:721–727. 2019.PubMed/NCBI View Article : Google Scholar

27 

Sun Y, Jiang C, Jiang J and Qiu L: Dexmedetomidine protects mice against myocardium ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS pathway. Clin Exp Pharmacol Physiol. 44:946–953. 2017.PubMed/NCBI View Article : Google Scholar

28 

Liu S, He Y, Shi J, Liu L, Ma H, He L and Guo Y: Allicin attenuates myocardial ischemia reperfusion injury in rats by inhibition of inflammation and oxidative stress. Transplant Proc. 51:2060–2065. 2019.PubMed/NCBI View Article : Google Scholar

29 

Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS and McManus BM: Inflammation in myocardial diseases. Circ Res. 110:126–144. 2012.PubMed/NCBI View Article : Google Scholar

30 

Buja LM: Myocardial ischemia and reperfusion injury. Cardiovasc Pathol. 14:170–175. 2005.PubMed/NCBI View Article : Google Scholar

31 

Mizushima N and Komatsu M: Autophagy: Renovation of cells and tissues. Cell. 147:728–741. 2011.PubMed/NCBI View Article : Google Scholar

32 

Hang P, Zhao J, Su Z, Sun H, Chen T, Zhao L and Du Z: Choline inhibits ischemia-reperfusion-induced cardiomyocyte autophagy in rat myocardium by activating Akt/mTOR signaling. Cell Physiol Biochem. 45:2136–2144. 2018.PubMed/NCBI View Article : Google Scholar

33 

Shanware NP, Bray K and Abraham RT: The PI3K, metabolic, and autophagy networks: Interactive partners in cellular health and disease. Annu Rev Pharmacol Toxicol. 53:89–106. 2013.PubMed/NCBI View Article : Google Scholar

34 

Tang H, Song X, Ling Y, Wang X, Yang P, Luo T and Chen A: Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway. Mol Med Rep. 15:3747–3754. 2017.PubMed/NCBI View Article : Google Scholar

35 

Li X, Zhu Q, Liu Y, Yang Z and Li B: Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K-Akt pathway. J Pharm Pharmacol. 70:259–267. 2018.PubMed/NCBI View Article : Google Scholar

36 

Jiang P and Mizushima N: LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods. 75:13–18. 2015.PubMed/NCBI View Article : Google Scholar

37 

Zhou M, Zou YG, Xue YZ, Wang XH, Gao H, Dong HW and Zhang Q: Long non-coding RNA H19 protects acute myocardial infarction through activating autophagy in mice. Eur Rev Med Pharmacol Sci. 22:5647–5651. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li F, Zhan Z, Qian J, Cao C, Yao W and Wang N: Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy. Exp Ther Med 22: 811, 2021.
APA
Li, F., Zhan, Z., Qian, J., Cao, C., Yao, W., & Wang, N. (2021). Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy. Experimental and Therapeutic Medicine, 22, 811. https://doi.org/10.3892/etm.2021.10243
MLA
Li, F., Zhan, Z., Qian, J., Cao, C., Yao, W., Wang, N."Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy". Experimental and Therapeutic Medicine 22.2 (2021): 811.
Chicago
Li, F., Zhan, Z., Qian, J., Cao, C., Yao, W., Wang, N."Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy". Experimental and Therapeutic Medicine 22, no. 2 (2021): 811. https://doi.org/10.3892/etm.2021.10243
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Zhan Z, Qian J, Cao C, Yao W and Wang N: Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy. Exp Ther Med 22: 811, 2021.
APA
Li, F., Zhan, Z., Qian, J., Cao, C., Yao, W., & Wang, N. (2021). Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy. Experimental and Therapeutic Medicine, 22, 811. https://doi.org/10.3892/etm.2021.10243
MLA
Li, F., Zhan, Z., Qian, J., Cao, C., Yao, W., Wang, N."Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy". Experimental and Therapeutic Medicine 22.2 (2021): 811.
Chicago
Li, F., Zhan, Z., Qian, J., Cao, C., Yao, W., Wang, N."Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway‑mediated inhibition of apoptosis, oxidative stress and autophagy". Experimental and Therapeutic Medicine 22, no. 2 (2021): 811. https://doi.org/10.3892/etm.2021.10243
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team