Open Access

Effect of erythropoietin on angiogenic potential of dental pulp cells

  • Authors:
    • Qimei Gong
    • Junyu Zeng
    • Xufang Zhang
    • Yihua Huang
    • Chanchan Chen
    • Jingjing Quan
    • Junqi Ling
  • View Affiliations

  • Published online on: July 28, 2021     https://doi.org/10.3892/etm.2021.10513
  • Article Number: 1079
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Erythropoietin (EPO) is a 34‑kDa glycoprotein that possesses the potential for angiogenesis, as well as anti‑inflammatory and anti‑apoptotic properties. The present study aimed to examine the effect of EPO on the angiogenesis of dental pulp cells (DPCs) and to explore the underlying mechanisms of these effects. It was demonstrated that EPO not only promoted DPCs proliferation but also induced angiogenesis of DPCs in a paracrine fashion. EPO enhanced the angiogenic capacity by stimulating DPCs to secrete a series of angiogenic cytokines. ELISA confirmed that high concentrations of EPO increased the production of MMP‑3 and angiopoietin‑1 but decreased the secretion of IL‑6. Furthermore, EPO activated the ERK1/2 and p38 signaling pathways in DPCs, while inhibition of these pathways diminished the angiogenesis capacity of DPCs. The present study suggested that EPO may have an important role in the repair and regeneration of dental pulp.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gong Q, Zeng J, Zhang X, Huang Y, Chen C, Quan J and Ling J: Effect of erythropoietin on angiogenic potential of dental pulp cells. Exp Ther Med 22: 1079, 2021
APA
Gong, Q., Zeng, J., Zhang, X., Huang, Y., Chen, C., Quan, J., & Ling, J. (2021). Effect of erythropoietin on angiogenic potential of dental pulp cells. Experimental and Therapeutic Medicine, 22, 1079. https://doi.org/10.3892/etm.2021.10513
MLA
Gong, Q., Zeng, J., Zhang, X., Huang, Y., Chen, C., Quan, J., Ling, J."Effect of erythropoietin on angiogenic potential of dental pulp cells". Experimental and Therapeutic Medicine 22.4 (2021): 1079.
Chicago
Gong, Q., Zeng, J., Zhang, X., Huang, Y., Chen, C., Quan, J., Ling, J."Effect of erythropoietin on angiogenic potential of dental pulp cells". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1079. https://doi.org/10.3892/etm.2021.10513