Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution

  • Authors:
    • Adina Elena Stanciu
    • Adina Zamfir‑Chiru‑Anton
    • Marcel Marian Stanciu
    • Mirela Gherghe
    • Razvan Hainarosie
    • Florentina Ligia Furtunescu
    • Dan Cristian Gheorghe
  • View Affiliations / Copyright

    Affiliations: Department of Carcinogenesis and Molecular Biology, ‘Prof. Dr. Alexandru Trestioreanu’ Institute of Oncology, 022328 Bucharest, Romania, ENT Department, ‘Grigore Alexandrescu’ Children's Emergency Hospital, 011743 Bucharest, Romania, Electrical Engineering Faculty, ‘Politehnica’ University, 060042, Bucharest, Romania, Department of Nuclear Medicine, ‘Prof. Dr. Alexandru Trestioreanu’ Institute of Oncology, 022328 Bucharest, Romania, ENT Department, ‘Prof. Dr. Dorin Hociota’ Institute of Phonoaudiology and Functional ENT and Cervicofacial Surgery, 050751 Bucharest, Romania, Department of Complementary Sciences, ‘Carol Davila’ University of Medicine and Pharmacy, 050463 Bucharest, Romania, ENT Department, ‘Carol Davila’ University of Medicine and Pharmacy, 050463 Bucharest, Romania
  • Article Number: 1113
    |
    Published online on: August 3, 2021
       https://doi.org/10.3892/etm.2021.10547
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

No prospective study has specifically examined the serum levels of matrix metalloproteinase‑9 (MMP‑9) and tissue inhibitor of metalloproteinase‑1 (TIMP‑1) in the early shock phase of burn‑injured patients. Thus, we aimed to detect early changes, activity dynamics, and the predictive value of MMP‑9, TIMP‑1, and the MMP‑9/TIMP‑1 ratio to better understand the early repair mechanisms for the development of future therapies for patients with thermal burns. Twenty‑five patients with a total body surface area (TBSA) affected by burn <25%, and 30 healthy subjects were enrolled in the study. Serum levels of MMP‑9 and TIMP‑1 were determined by the ELISA method. Our results showed that MMP‑9 concentrations increased immediately after injury and remained on a plateau. In contrast, TIMP‑1 showed an upward trend throughout the 7‑day study period, and the time course of the MMP‑9/TIMP‑1 ratio followed the inverse dynamics of TIMP‑1. Analysis of the areas under the receiver operating characteristic (ROC) curves (AUC) showed that patients with burn wounds tended to have a MMP‑9 value higher than 421.5 ng/ml (AUC=0.979), TIMP‑1 value higher than 231.6 ng/ml (AUC=0.908), and MMP‑9/TIMP‑1 ratio higher than 2.31 (AUC=0.959) (P<0.001). Our findings suggest that although the variations in the two biomarkers were different regarding the time of the initial insult, their ratio is a specific and sensitive indicator of burn evolutivity in patients with a TBSA affected by a burn <25%.
View Figures

Figure 1

Figure 2

View References

1 

Lateef Z, Stuart G, Jones N, Mercer A, Fleming S and Wise L: The cutaneous inflammatory response to thermal burn injury in a murine model. Int J Mol Sci. 20(538)2019.PubMed/NCBI View Article : Google Scholar

2 

Hofmann E, Fink J, Eberl A, Prugger EM, Kolb D, Luze H, Schwingenschuh S, Birngruber T, Magnes C, Mautner SI, et al: A novel human ex vivo skin model to study early local responses to burn injuries. Sci Rep. 11(364)2021.PubMed/NCBI View Article : Google Scholar

3 

Suceveanu AI, Mazilu L, Katsiki N, Parepa I, Voinea F, Pantea-Stoian A, Rizzo M, Botea F, Herlea V, Serban D and Suceveanu AP: NLRP3 inflammasome biomarker-could be the new tool for improved cardiometabolic syndrome outcome. Metabolites. 10(448)2020.PubMed/NCBI View Article : Google Scholar

4 

Yu G, Li Y, Ye L, Wang X, Zhang J, Dong Z and Jiang D: Exogenous peripheral blood mononuclear cells affect the healing process of deep-degree burns. Mol Med Rep. 16:8110–8122. 2017.PubMed/NCBI View Article : Google Scholar

5 

Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, Martinez-Avila N and Martinez-Fierro ML: The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 21(9739)2020.PubMed/NCBI View Article : Google Scholar

6 

Raeeszadeh-Sarmazdeh M, Do LD and Hritz BG: Metalloproteinases and their inhibitors: Potential for the development of new therapeutics. Cells. 9(1313)2020.PubMed/NCBI View Article : Google Scholar

7 

Plichta JK, Holmes CJ, Gamelli RL and Radek KA: Local burn injury promotes defects in the epidermal lipid and antimicrobial peptide barriers in human autograft skin and burn margin: Implications for burn wound healing and graft survival. J Burn Care Res. 38:e212–e226. 2017.PubMed/NCBI View Article : Google Scholar

8 

Tokuhara CK, Santesso MR, Oliveira GSN, Ventura TMDS, Doyama JT, Zambuzzi WF and Oliveira RC: Updating the role of matrix metalloproteinases in mineralized tissue and related diseases. J Appl Oral Sci. 27(e20180596)2019.PubMed/NCBI View Article : Google Scholar

9 

Guo HF, Ali RM, Hamid RA, Chang SK, Rahman MH, Zainal Z and Khaza'ai H: Temporal changes in the cell population and wound healing-related gene expression in deep partial-thickness burn wound model. Biomed Dermatol 4, 2020.

10 

Dasu MR, Spies M, Barrow RE and Herndon DN: Matrix metalloproteinases and their tissue inhibitors in severely burned children. Wound Repair Regen. 11:177–180. 2003.PubMed/NCBI View Article : Google Scholar

11 

Ulrich D, Noah EM, von Heimburg D and Pallua N: TIMP-1, MMP-2, MMP-9, and PIINP as serum markers for skin fibrosis in patients following severe burn trauma. Plast Reconstr Surg. 111:1423–1431. 2003.PubMed/NCBI View Article : Google Scholar

12 

Hästbacka J, Fredén F, Hult M, Bergquist M, Wilkman E, Vuola J, Sorsa T, Tervahartiala T and Huss F: Matrix Metalloproteinases-8 and -9 and tissue inhibitor of metalloproteinase-1 in burn patients. A prospective observational study. PLoS One. 10(e0125918)2015.PubMed/NCBI View Article : Google Scholar

13 

Lang TC, Zhao R, Kim A, Wijewardena A, Vandervord J, Xue M and Jackson CJ: A critical update of the assessment and acute management of patients with severe burns. Adv Wound Care (New Rochelle). 8:607–633. 2019.PubMed/NCBI View Article : Google Scholar

14 

Nagy B, Szelig L, Rendeki S, Loibl C, Rézmán B, Lantos J, Bogár L and Csontos C: Dynamic changes of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 after burn injury. J Crit Care. 30:162–166. 2015.PubMed/NCBI View Article : Google Scholar

15 

Stanciu AE, Zamfir-Chiru-Anton A, Stanciu MM, Pantea-Stoian A, Nitipir C and Gheorghe DC: Serum melatonin is inversely associated with matrix metalloproteinase-9 in oral squamous cell carcinoma. Oncol Lett. 19:3011–3020. 2020.PubMed/NCBI View Article : Google Scholar

16 

Giretzlehner M, Dirnberger J, Owen R, Haller HL, Lumenta DB and Kamolz LP: The determination of total burn surface area: How much difference? Burns. 39:1107–1113. 2013.PubMed/NCBI View Article : Google Scholar

17 

Chong HP, Quinn L, Jeeves A, Cooksey R, Lodge M, Carney B and Molony D: A comparison study of methods for estimation of a burn surface area: Lund and Browder, e-burn and Mersey Burns. Burns. 46:483–489. 2020.PubMed/NCBI View Article : Google Scholar

18 

Brychta P and Magnette A: the Executive Committee and PAM Committee of European Burn Association (EBA) (2017). European Practice Guidelines for Burn Care 2017. Available from: https://www.euroburn.org/wp-content/uploads/EBA-Guidelines-Version-4-2017.pdf.

19 

Stagg HW, Whaley JG, Tharakan B, Hunter FA, Jupiter D, Little DC, Davis ML, Smythe WR and Childs EW: Doxycycline attenuates burn induced microvascular hyperpermeability. J Trauma Acute Care Surg. 75:1040–1046. 2013.PubMed/NCBI View Article : Google Scholar

20 

Stanciu AE, Zamfir-Chiru-Anton A, Stanciu MM, Stoian AP, Jinga V, Nitipir C, Bucur A, Pituru TS, Arsene AL, Dragoi CM, et al: Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma. Oncol Lett. 19:1537–1543. 2020.PubMed/NCBI View Article : Google Scholar

21 

Stoian Pantea A, Mitrofan G and Colceag F: Oxidative Stress in Diabetes. A model of complex thinking applied in medicine. Rev Chim. 96:2515–2519. 2018.

22 

Stanciu AE: Cytokines in heart failure. Adv Clin Chem. 93:63–113. 2019.PubMed/NCBI View Article : Google Scholar

23 

Lorente L, Martin MM, Labarta L, Diaz C, Solé-Violán J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, et al: Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care. 13(R158)2009.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Stanciu AE, Zamfir‑Chiru‑Anton A, Stanciu MM, Gherghe M, Hainarosie R, Furtunescu FL and Gheorghe DC: Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution. Exp Ther Med 22: 1113, 2021.
APA
Stanciu, A.E., Zamfir‑Chiru‑Anton, A., Stanciu, M.M., Gherghe, M., Hainarosie, R., Furtunescu, F.L., & Gheorghe, D.C. (2021). Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution. Experimental and Therapeutic Medicine, 22, 1113. https://doi.org/10.3892/etm.2021.10547
MLA
Stanciu, A. E., Zamfir‑Chiru‑Anton, A., Stanciu, M. M., Gherghe, M., Hainarosie, R., Furtunescu, F. L., Gheorghe, D. C."Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution". Experimental and Therapeutic Medicine 22.4 (2021): 1113.
Chicago
Stanciu, A. E., Zamfir‑Chiru‑Anton, A., Stanciu, M. M., Gherghe, M., Hainarosie, R., Furtunescu, F. L., Gheorghe, D. C."Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1113. https://doi.org/10.3892/etm.2021.10547
Copy and paste a formatted citation
x
Spandidos Publications style
Stanciu AE, Zamfir‑Chiru‑Anton A, Stanciu MM, Gherghe M, Hainarosie R, Furtunescu FL and Gheorghe DC: Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution. Exp Ther Med 22: 1113, 2021.
APA
Stanciu, A.E., Zamfir‑Chiru‑Anton, A., Stanciu, M.M., Gherghe, M., Hainarosie, R., Furtunescu, F.L., & Gheorghe, D.C. (2021). Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution. Experimental and Therapeutic Medicine, 22, 1113. https://doi.org/10.3892/etm.2021.10547
MLA
Stanciu, A. E., Zamfir‑Chiru‑Anton, A., Stanciu, M. M., Gherghe, M., Hainarosie, R., Furtunescu, F. L., Gheorghe, D. C."Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution". Experimental and Therapeutic Medicine 22.4 (2021): 1113.
Chicago
Stanciu, A. E., Zamfir‑Chiru‑Anton, A., Stanciu, M. M., Gherghe, M., Hainarosie, R., Furtunescu, F. L., Gheorghe, D. C."Clinical significance of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in the first phase of burn trauma evolution". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1113. https://doi.org/10.3892/etm.2021.10547
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team