Open Access

Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate

  • Authors:
    • Mary A. Zimmerman
    • Mia Hall
    • Qi Qi
    • Suresh L. Mehta
    • Guisheng Chen
    • P. Andy Li
  • View Affiliations

  • Published online on: September 14, 2021     https://doi.org/10.3892/etm.2021.10730
  • Article Number: 1295
  • Copyright: © Zimmerman et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glutamate‑induced excitotoxicity is a well-recognized cause of neuronal cell death. Nutritional supplementation with Coenzyme Q10 (CoQ10) has been previously demonstrated to serve neuro‑protective effects against glutamate‑induced excitotoxicity. The aim of the present study was to determine whether the protective effect of CoQ10 against glutamate toxicity could be attributed to stimulating mitochondrial biogenesis. Mouse hippocampal neuronal HT22 cells were incubated with glutamate with or without ubisol Q10. The results revealed that glutamate significantly decreased levels of mitochondrial biogenesis related proteins, including peroxisome proliferator‑activated receptor gamma coactivator (PGC)‑1α and nuclear respiratory factor (NRF)2. Additionally, glutamate reduced mitochondrial biogenesis, as determined using a mitochondrial biogenesis kit. Pretreatment with CoQ10 prevented decreases in phosphorylated (p)‑Akt, p‑cAMP response element‑binding protein, PGC‑1α, NRF2 and mitochondrial transcription factor A, increasing mitochondrial biogenesis. Taken together, the results described a novel mechanism of CoQ10‑induced neuroprotection and indicated a central role for mitochondrial biogenesis in protecting against glutamate‑induced excitotoxicity.

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November-2021
Volume 22 Issue 5

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Spandidos Publications style
Zimmerman MA, Hall M, Qi Q, Mehta SL, Chen G and Li PA: Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate. Exp Ther Med 22: 1295, 2021
APA
Zimmerman, M.A., Hall, M., Qi, Q., Mehta, S.L., Chen, G., & Li, P.A. (2021). Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate. Experimental and Therapeutic Medicine, 22, 1295. https://doi.org/10.3892/etm.2021.10730
MLA
Zimmerman, M. A., Hall, M., Qi, Q., Mehta, S. L., Chen, G., Li, P. A."Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate". Experimental and Therapeutic Medicine 22.5 (2021): 1295.
Chicago
Zimmerman, M. A., Hall, M., Qi, Q., Mehta, S. L., Chen, G., Li, P. A."Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1295. https://doi.org/10.3892/etm.2021.10730