Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway

  • Authors:
    • Yuan Yuan Cheng
    • Xue Yang
    • Xin Gao
    • Si Xin Song
    • Ming Feng Yang
    • Fang Min Xie
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Tai'an Central Hospital, Tai'an, Shandong 271000, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266100, P.R. China, Department of Neurosurgery, The Second Affiliated Hospital of Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, Shandong 270000, P.R. China, Institute of Basic Medicine of Shangdong, First Medical University and Shandong Academy of Medical Sciences, Tai'an, Shandong 270000, P.R. China
  • Article Number: 1364
    |
    Published online on: September 27, 2021
       https://doi.org/10.3892/etm.2021.10798
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chemoresistance is the primary cause of the poor outcome of glioblastoma multiforme (GBM) therapy. Leucine‑rich repeat‑containing G‑protein coupled receptor 6 (LGR6) is involved in the growth and proliferation of several types of cancer, including gastric cancer and ovarian cancer. Therefore, the aim of the present study was to investigate the role of LGR6 in GBM malignancy and chemoresistance. Cell counting kit‑8 and Matrigel®‑Transwell assays were conducted to assess GBM cell viability and invasion. The effect of LGR6 on cell cycle progression and activation of Akt signaling was analyzed by performing propidium iodide staining and western blotting, respectively. The results demonstrated that LGR6, a microRNA‑1236‑3p target candidate, promoted GBM cell viability and invasion, and mediated temozolomide sensitivity in SHG‑44 and U251 GBM cells. In addition, LGR6 triggered the activation of the Akt signaling pathway during GBM progression. Collectively, the results of the present study suggested that LGR6 promoted GBM malignancy and chemoresistance, at least in part, by activating the Akt signaling pathway. The results may aid with the identification of a novel therapeutic target and strategy for GBM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Jia B, Liu W, Gu J, Wang J, Lv W, Zhang W, Hao Q, Pang Z, Mu N, Zhang W and Guo Q: MiR-7-5p suppresses stemness and enhances temozolomide sensitivity of drug-resistant glioblastoma cells by targeting Yin Yang 1. Exp Cell Res. 375:73–81. 2019.PubMed/NCBI View Article : Google Scholar

2 

McLendon R, Friedman AH, Bigner D, Van Meir EG, Brat DJ, Mastrogianakis G, Olson JJ, Mikkelsen T, Lehman N, Aldape K, et al: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 455:1061–1068. 2008.PubMed/NCBI View Article : Google Scholar

3 

Shi F, Guo H, Zhang R, Liu H, Wu L, Wu Q, Liu J, Liu T and Zhang Q: The PI3K inhibitor GDC-0941 enhances radiosensitization and reduces chemoresistance to temozolomide in GBM cell lines. Neuroscience. 346:298–308. 2017.PubMed/NCBI View Article : Google Scholar

4 

Schreck KC and Grossman SA: Role of temozolomide in the treatment of cancers involving the central nervous system. Oncology (Williston Park). 32:555–560, 569. 2018.PubMed/NCBI

5 

Stephen ZR, Kievit FM, Veiseh O, Chiarelli PA, Fang C, Wang K, Hatzinger SJ, Ellenbogen RG, Silber JR and Zhang M: Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors. ACS Nano. 8:10383–10395. 2014.PubMed/NCBI View Article : Google Scholar

6 

Stavrovskaya AA, Shushanov SS and Rybalkina EY: Problems of glioblastoma multiforme drug resistance. Biochemistry (Mosc). 81:91–100. 2016.PubMed/NCBI View Article : Google Scholar

7 

Choi S, Yu Y, Grimmer MR, Wahl M, Chang SM and Costello JF: Temozolomide-associated hypermutation in gliomas. Neuro Oncol. 20:1300–1309. 2018.PubMed/NCBI View Article : Google Scholar

8 

Wang F, Dai CQ, Zhang LR, Bing C, Qin J and Liu YF: Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer. Int J Mol Med. 42:625–632. 2018.PubMed/NCBI View Article : Google Scholar

9 

Wang W, Ding S and Zhang H, Li J, Zhan J and Zhang H: G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma. Front Med. 13:482–491. 2019.PubMed/NCBI View Article : Google Scholar

10 

Ke J, Ma P, Chen J, Qin J and Qian H: LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway. Onco Targets Ther. 11:3025–3033. 2018.PubMed/NCBI View Article : Google Scholar

11 

Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C and Wu W: R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for xenopus myogenesis. Dev Cell. 7:525–534. 2004.PubMed/NCBI View Article : Google Scholar

12 

Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K and Funk WD: R-Spondin proteins: A novel link to beta-catenin activation. Cell Cycle. 5:23–26. 2006.PubMed/NCBI View Article : Google Scholar

13 

Nam JS, Turcotte TJ, Smith PF, Choi S and Yoon JK: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 281:13247–13257. 2006.PubMed/NCBI View Article : Google Scholar

14 

Raslan AA and Yoon JK: R-spondins: Multi-mode WNT signaling regulators in adult stem cells. Int J Biochem Cell Biol. 106:26–34. 2019.PubMed/NCBI View Article : Google Scholar

15 

Zhang Y, Guo L, Lu X, Cheng C, Sun S, Li W, Zhao L, Lai C, Zhang S, Yu C, et al: Characterization of Lgr6+ cells as an enriched population of hair cell progenitors compared to Lgr5+ cells for hair cell generation in the neonatal mouse cochlea. Front Mol Neurosci. 11(147)2018.PubMed/NCBI View Article : Google Scholar

16 

Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, et al: RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 557:564–569. 2018.PubMed/NCBI View Article : Google Scholar

17 

Schindler AJ, Watanabe A and Howell SB: LGR5 and LGR6 in stem cell biology and ovarian cancer. Oncotarget. 9:1346–1355. 2017.PubMed/NCBI View Article : Google Scholar

18 

Bin BH, Bhin J, Takaishi M, Toyoshima KE, Kawamata S, Ito K, Hara T, Watanabe T, Irié T, Takagishi T, et al: Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis. Proc Natl Acad Sci USA. 114:12243–12248. 2017.PubMed/NCBI View Article : Google Scholar

19 

Guinot A, Oeztuerk-Winder F and Ventura JJ: miR-17-92/p38α dysregulation enhances Wnt signaling and selects Lgr6+ cancer stem-like cells during lung adenocarcinoma progression. Cancer Res. 76:4012–4022. 2016.PubMed/NCBI View Article : Google Scholar

20 

Roos A, Dhruv HD, Peng S, Inge LJ, Tuncali S, Pineda M, Millard N, Mayo Z, Eschbacher JM, Loftus JC, et al: EGFRvIII-stat5 signaling enhances glioblastoma cell migration and survival. Mol Cancer Res. 16:1185–1195. 2018.PubMed/NCBI View Article : Google Scholar

21 

Huang W, Ding X, Ye H, Wang J, Shao J and Huang T: Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway. Neuroreport. 29:1578–1585. 2018.PubMed/NCBI View Article : Google Scholar

22 

Wang L, Wang J, Jin T, Zhou Y and Chen Q: FoxG1 facilitates proliferation and inhibits differentiation by downregulating FoxO/Smad signaling in glioblastoma. Biochem Biophys Res Commun. 504:46–53. 2018.PubMed/NCBI View Article : Google Scholar

23 

Vainchenker W, Leroy E, Gilles L, Marty C, Plo I and Constantinescu SN: JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders. F1000Res. 7(82)2018.PubMed/NCBI View Article : Google Scholar

24 

Berendsen S, Spliet WGM, Geurts M, Van Hecke W, Seute T, Snijders TJ, Bours V, Bell EH, Chakravarti A and Robe PA: Epilepsy associates with decreased HIF-1α/STAT5b signaling in glioblastoma. Cancers (Basel). 11(41)2019.PubMed/NCBI View Article : Google Scholar

25 

Shen X, Zhang J, Zhang X, Wang Y, Hu Y and Guo J: Retinoic acid-induced protein 14 (RAI14) promotes mTOR-mediated inflammation under inflammatory stress and chemical hypoxia in a U87 glioblastoma cell line. Cell Mol Neurobiol. 39:241–254. 2019.PubMed/NCBI View Article : Google Scholar

26 

Ke XX, Pang Y, Chen K, Zhang D, Wang F, Zhu S, Mao J, Hu X, Zhang G and Cui H: Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway. Oncol Rep. 40:3313–3322. 2018.PubMed/NCBI View Article : Google Scholar

27 

Cheng P, Ma Y, Gao Z and Duan L: High mobility group box 1 (HMGB1) predicts invasion and poor prognosis of glioblastoma multiforme via activating AKT signaling in an autocrine pathway. Med Sci Monit. 24:8916–8924. 2018.PubMed/NCBI View Article : Google Scholar

28 

Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J and Sarkaria JN: ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol. 110:349–357. 2012.PubMed/NCBI View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

30 

Sun Z, Xue H, Wei Y, Wang C, Yu R, Wang C, Wang S, Xu J, Qian M, Meng Q and Li G: Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. Clin Sci (Lond). 133:1167–1184. 2019.PubMed/NCBI View Article : Google Scholar

31 

Wen YT, Wu AT, Bamodu OA, Wei L, Lin CM, Yen Y, Chao TY, Mukhopadhyay D, Hsiao M and Huang HS: A novel multi-target small molecule, LCC-09, inhibits stemness and therapy-resistant phenotypes of glioblastoma cells by increasing miR-34a and deregulating the DRD4/Akt/mTOR signaling axis. Cancers (Basel). 11(1442)2019.PubMed/NCBI View Article : Google Scholar

32 

Kim EH, Jo Y, Sai S, Park MJ, Kim JY, Kim JS, Lee YJ, Cho JM, Kwak SY, Baek JH, et al: Tumor-treating fields induce autophagy by blocking the Akt2/miR29b axis in glioblastoma cells. Oncogene. 38:6630–6646. 2019.PubMed/NCBI View Article : Google Scholar

33 

An JX, Ma MH, Zhang CD, Shao S, Zhou NM and Dai DQ: miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2. Cancer Cell Int. 18(66)2018.PubMed/NCBI View Article : Google Scholar

34 

Li C, Ge Q, Liu J, Zhang Q, Wang C, Cui K and Chen Z: Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells. Tumour Biol. 39(1010428317710824)2017.PubMed/NCBI View Article : Google Scholar

35 

Bian T, Jiang D, Liu J, Yuan X, Feng J, Li Q, Zhang Q, Li X, Liu Y and Zhang J: miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells. Biochem Biophys Res Commun. 492:461–467. 2017.PubMed/NCBI View Article : Google Scholar

36 

Wen PY and Kesari S: Malignant gliomas in adults. N Engl J Med. 359:492–507. 2008.PubMed/NCBI View Article : Google Scholar

37 

Torre LA, Bray FI, Siegel RL, Ferlay J, Lortettieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

38 

Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery M, DelRosario R, Kang HC, Wong CE, et al: Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Nat Genet. 49:1624–1632. 2017.PubMed/NCBI View Article : Google Scholar

39 

de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, et al: Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 476:293–297. 2011.PubMed/NCBI View Article : Google Scholar

40 

Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM and Niehrs C: LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep. 12:1055–1061. 2011.PubMed/NCBI View Article : Google Scholar

41 

Lebensohn AM and Rohatgi R: R-spondins can potentiate WNT signaling without LGRs. Elife. 7(e33126)2018.PubMed/NCBI View Article : Google Scholar

42 

Chong ZZ, Li F and Maiese K: Employing new cellular therapeutic targets for Alzheimer's disease: A change for the better? Curr Neurovasc Res. 2:55–72. 2005.PubMed/NCBI View Article : Google Scholar

43 

Hers I, Vincent EE and Tavaré JM: Akt signalling in health and disease. Cell Signal. 23:1515–1527. 2011.PubMed/NCBI View Article : Google Scholar

44 

Luo J, Manning BD and Cantley LC: Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell. 4:257–262. 2003.PubMed/NCBI View Article : Google Scholar

45 

Angers S and Moon RT: Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol. 10:468–477. 2009.PubMed/NCBI View Article : Google Scholar

46 

Yi GZ, Liu YW, Xiang W, Wang H, Chen ZY, Xie SD and Qi ST: Akt and β-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line. J Neurol Sci. 367:101–106. 2016.PubMed/NCBI View Article : Google Scholar

47 

Hayes J, Peruzzi PP and Lawler S: MicroRNAs in cancer: Biomarkers, functions and therapy. Trends Mol Med. 20:460–469. 2014.PubMed/NCBI View Article : Google Scholar

48 

Acunzo M, Romano G, Wernicke D and Croce CM: MicroRNA and cancer-a brief overview. Adv Biol Regul. 57:1–9. 2015.PubMed/NCBI View Article : Google Scholar

49 

Gregory RI and Shiekhattar R: MicroRNA biogenesis and cancer. Cancer Res. 65:3509–3512. 2005.PubMed/NCBI View Article : Google Scholar

50 

An JX, Ma ZS, Ma MH, Shao S, Cao FL and Dai DQ: MiR-1236-3p serves as a new diagnostic and prognostic biomarker for gastric cancer. Cancer Biomark. 25:127–132. 2019.PubMed/NCBI View Article : Google Scholar

51 

Zhu XP, Wang XL, Ma J, Fang YF, Zhang HJ, Zhang C and Feng MC: Down-regulation of miR-1236-3p is correlated with clinical progression and unfavorable prognosis in gastric cancer. Eur Rev Med Pharmacol Sci. 22:5914–5919. 2018.PubMed/NCBI View Article : Google Scholar

52 

Li QH, Liu Y, Chen S, Zong ZH, Du YP, Sheng XJ and Zhao Y: circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge. Biomed Pharmacother. 114(108832)2019.PubMed/NCBI View Article : Google Scholar

53 

Zhang Q, Miao S, Li C, Cui K, Ge Q and Chen Z: S-phase kinase-associated protein 2 impairs the inhibitory effects of miR-1236-3p on bladder tumors. Am J Transl Res. 10:731–743. 2018.PubMed/NCBI

54 

Wang Z, Liu L, Guo X, Guo C and Wang W: microRNA-1236-3p regulates DDP resistance in lung cancer cells. Open Med (Wars). 14:41–51. 2019.PubMed/NCBI View Article : Google Scholar

55 

Carè A, Felicetti F, Meccia E, Bottero L, Parenza M, Stoppacciaro A, Peschle C and Colombo MP: HOXB7: A key factor for tumor-associated angiogenic switch. Cancer Res. 61:6532–6539. 2001.PubMed/NCBI

56 

Duan X, Liu D, Wang Y and Chen Z: Circular RNA hsa_circ_0074362 Promotes Glioma Cell Proliferation, Migration, and invasion by attenuating the inhibition of miR-1236-3p on HOXB7 expression. DNA Cell Biol. 37:917–924. 2018.PubMed/NCBI View Article : Google Scholar

57 

Monterisi S, Lo Riso P, Russo K, Bertalot G, Vecchi M, Testa G, Di Fiore PP and Bianchi F: HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene. 37:3575–3588. 2018.PubMed/NCBI View Article : Google Scholar

58 

Gao RT, Zhan LP, Meng C, Zhang N, Chang SM, Yao R and Li C: Homeobox B7 promotes the osteogenic differentiation potential of mesenchymal stem cells by activating RUNX2 and transcript of BSP. Int J Clin Exp Med. 8:10459–10470. 2015.PubMed/NCBI

59 

Cortesi E and Ventura JJ: Lgr6: From stemness to cancer progression. J Lung Health Dis. 3:12–15. 2019.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cheng YY, Yang X, Gao X, Song SX, Yang MF and Xie FM: LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway. Exp Ther Med 22: 1364, 2021.
APA
Cheng, Y.Y., Yang, X., Gao, X., Song, S.X., Yang, M.F., & Xie, F.M. (2021). LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway. Experimental and Therapeutic Medicine, 22, 1364. https://doi.org/10.3892/etm.2021.10798
MLA
Cheng, Y. Y., Yang, X., Gao, X., Song, S. X., Yang, M. F., Xie, F. M."LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway". Experimental and Therapeutic Medicine 22.6 (2021): 1364.
Chicago
Cheng, Y. Y., Yang, X., Gao, X., Song, S. X., Yang, M. F., Xie, F. M."LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1364. https://doi.org/10.3892/etm.2021.10798
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng YY, Yang X, Gao X, Song SX, Yang MF and Xie FM: LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway. Exp Ther Med 22: 1364, 2021.
APA
Cheng, Y.Y., Yang, X., Gao, X., Song, S.X., Yang, M.F., & Xie, F.M. (2021). LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway. Experimental and Therapeutic Medicine, 22, 1364. https://doi.org/10.3892/etm.2021.10798
MLA
Cheng, Y. Y., Yang, X., Gao, X., Song, S. X., Yang, M. F., Xie, F. M."LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway". Experimental and Therapeutic Medicine 22.6 (2021): 1364.
Chicago
Cheng, Y. Y., Yang, X., Gao, X., Song, S. X., Yang, M. F., Xie, F. M."LGR6 promotes glioblastoma malignancy and chemoresistance by activating the Akt signaling pathway". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1364. https://doi.org/10.3892/etm.2021.10798
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team