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miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways

  • Authors:
    • Li Jia
    • Bin Lei
    • Huaijun Gao
    • Lin Jia
    • Dan Luo
    • Jianjun Han
    • Bingxin Jia
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, Sichuan 621000, P.R. China, Department of General Surgery, Yulin Traditional Chinese Medicine Hospital, Yulin, Shaanxi 719000, P.R. China, Department of Urology Surgery, Yulin Traditional Chinese Medicine Hospital, Yulin, Shaanxi 719000, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 98
    |
    Published online on: December 1, 2021
       https://doi.org/10.3892/etm.2021.11021
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Abstract

Prostate cancer occurs in the prostatic epithelium and poses a threat to the health of middle‑aged and older males. The objective of the present study was to explore the roles of microRNA (miRNA/miR)‑130b in prostate cancer and potential molecular mechanisms in order to control the migration and invasion of prostate cancer. For this purpose, reverse transcription‑PCR was performed to evaluate the mRNA levels of DLL1, phosphoinositide‑3 kinase (PI3K), protein kinase B (Akt) and matrix metalloproteinase (MMP)9, and western blot analysis was carried out to detect the protein expression levels of DLL1, phosphorylated (p)‑PI3K, p‑Akt and MMP9. A Transwell assay was conducted to examine the invasion rate of prostate cancer cells. Furthermore, a scratch wound assay was performed to examine the migration rate of prostate cancer cells. A luciferase assay was performed to examine the interaction between miRNA and its target mRNA. The results revealed that miR‑130b had abnormal (low) expression in tumor tissues compared with that in the adjacent normal tissue. An miR‑130b mimic suppressed the expression of DLL1. The expression of p‑PI3K, p‑Akt and MMP9 in prostate cancer cells transfected with the miR‑130b mimic was decreased in comparison to the negative control and control groups. Furthermore, migration and invasion were significantly suppressed in the miR‑130b mimic group. In conclusion, a novel pathway interlinking miR‑130b and MMP9, p‑Akt and p‑PI3K, which regulates the migration and invasion of prostate cancer cells, was identified. These findings provide an intriguing biomarker and treatment strategy for patients with prostate cancer.
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1 

Chen DQ, Yu C, Zhang XF, Liu ZF, Wang R, Jiang M, Chen H, Yan F, Tao M, Chen LB, et al: HDAC3-mediated silencing of miR-451 decreases chemosensitivity of patients with metastatic castration-resistant prostate cancer by targeting NEDD9. Ther Adv Med Oncol. 10(1758835918783132)2018.PubMed/NCBI View Article : Google Scholar

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017.PubMed/NCBI View Article : Google Scholar

3 

Zhu JG, Pan C, Jiang J, Deng M, Gao H, Men B, McClelland M, Mercola D, Zhong WD and Jia Z: Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China. Oncotarget. 6:16757–16765. 2015.PubMed/NCBI View Article : Google Scholar

4 

Paliouras AR, Monteverde T and Garofalo M: Oncogene-induced regulation of microrna expression: Implications for cancer initiation, progression and therapy. Cancer Lett. 421:152–160. 2018.PubMed/NCBI View Article : Google Scholar

5 

Zhang C, Qian D, Zhao H, Lv N, Yu P and Sun Z: miR-17 improves insulin sensitivity through inhibiting expression of ASK1 and anti-inflammation of macrophages. Biomed Pharmacother. 100:448–454. 2018.PubMed/NCBI View Article : Google Scholar

6 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004.PubMed/NCBI View Article : Google Scholar

7 

Wu N, Han Y, Liu H, Jiang M, Chu Y, Cao J, Lin J, Liu Y, Xu B and Xie X: miR-5590-3p inhibited tumor growth in gastric cancer by targeting DDX5/AKT/m-TOR pathway. Biochem Biophys Res Commun. 503:1491–1497. 2018.PubMed/NCBI View Article : Google Scholar

8 

Sun L, Guo Z, Sun J, Li J, Dong Z, Zhang Y, Chen J, Kan Q and Yu Z: MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. Biomed Pharmacother. 107:168–176. 2018.PubMed/NCBI View Article : Google Scholar

9 

Kaalund SS, Venø MT, Bak M, Møller RS, Laursen H, Madsen F, Broholm H, Quistorff B, Uldall P, Tommerup N, et al: Aberrant expression of mir-218 and mir-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance. Epilepsia. 55:2017–2027. 2014.PubMed/NCBI View Article : Google Scholar

10 

Shen J and Li M: Microrna-744 inhibits cellular proliferation and invasion of colorectal cancer by directly targeting oncogene notch1. Oncol Res: Feb 22, 2018 (Epub ahead of print). doi: 10.3727/096504018X15188747585738.

11 

Chen Q, Zhao X, Zhang H, Yuan H, Zhu M, Sun Q, Lai X, Wang Y, Huang J, Yan J and Yu J: miR-130b suppresses prostate cancer metastasis through down-regulation of MMP2. Mol Carcinog. 54:1292–1300. 2015.PubMed/NCBI View Article : Google Scholar

12 

Zhang JP, Li N, Bai WZ, Qiu XC, Ma BA, Zhou Y, Fan QY and Shan LQ: Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion. Braz J Med Biol Res. 47:299–306. 2014.PubMed/NCBI View Article : Google Scholar

13 

Pang RT, Leung CO, Lee CL, Lam KK, Ye TM, Chiu PC and Yeung WS: MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer. 13(25)2013.PubMed/NCBI View Article : Google Scholar

14 

Yu F, Hao X, Zhao H, Ge C, Yao M, Yang S and Li J: Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma. Liver Int. 30:703–714. 2010.PubMed/NCBI View Article : Google Scholar

15 

Purow BW, Haque RM, Noel MW, Su Q, Burdick MJ, Lee J, Sundaresan T, Pastorino S, Park JK, Mikolaenko I, et al: Expression of notch-1 and its ligands, delta-like-1 and jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 65:2353–2363. 2005.PubMed/NCBI View Article : Google Scholar

16 

Scorey N, Fraser SP, Patel P, Pridgeon C, Dallman MJ and Djamgoz MB: Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: Independent modulation of in vitro motility. Prostate Cancer Prostatic Dis. 9:399–406. 2006.PubMed/NCBI View Article : Google Scholar

17 

Adimonye A, Stankiewicz E, Kudahetti S, Trevisan G, Tinwell B, Corbishley C, Lu YJ, Watkin N and Berney D: Analysis of the pi3k-Akt-mtor pathway in penile cancer: Evaluation of a therapeutically targetable pathway. Oncotarget. 9:16074–16086. 2018.PubMed/NCBI View Article : Google Scholar

18 

Cretella D, Ravelli A, Fumarola C, La Monica S, Digiacomo G, Cavazzoni A, Alfieri R, Biondi A, Generali D, Bonelli M and Petronini PG: The anti-tumor efficacy of cdk4/6 inhibition is enhanced by the combination with pi3k/Akt/mtor inhibitors through impairment of glucose metabolism in tnbc cells. J Exp Clin Cancer Res. 37(72)2018.PubMed/NCBI View Article : Google Scholar

19 

Li H, Xu W, Ma Y, Zhou S and Xiao R: Milk fat globule membrane protein promotes c2c12 cell proliferation through the pi3k/Akt signaling pathway. Int J Biol Macromol. 114:1305–1314. 2018.PubMed/NCBI View Article : Google Scholar

20 

Hassan M, Watari H, AbuAlmaaty A, Ohba Y and Sakuragi N: Apoptosis and molecular targeting therapy in cancer. Biomed Res Int. 2014(150845)2014.PubMed/NCBI View Article : Google Scholar

21 

Shi X, Yang L, Xie J, Zhao Y, Cong J, Li Z, Li H, Cheng X and Fan J: UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway. Mol Med Rep. 18:3382–3388. 2018.PubMed/NCBI View Article : Google Scholar

22 

Zhang XR, Wang SY, Sun W and Wei C: Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. Mol Med Rep. 18:3429–3436. 2018.PubMed/NCBI View Article : Google Scholar

23 

Paplomata E and O'Regan R: The PI3K/AKT/mTOR pathway in breast cancer: Targets, trials and biomarkers. Ther Adv Med Oncol. 6:154–166. 2014.PubMed/NCBI View Article : Google Scholar

24 

Wang HY, Zhang CY, Xu LT, Zang K, Ning ZY, Jiang F, Chi HY, Zhu XY and Meng ZQ: Bufalin suppressed hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway. Oncotarget. 7:320193–20208. 2016.PubMed/NCBI View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

26 

Chen Y, Zhao F, Cui D, Jiang R, Chen J, Huang Q and Shi J: Hoxd-as1/mir-130a sponge regulates glioma development by targeting e2f8. Int J Cancer. 142:2313–2322. 2018.PubMed/NCBI View Article : Google Scholar

27 

Tang C, Yang Z, Chen D, Xie Q, Peng T, Wu J and Qi S: Downregulation of mir-130a promotes cell growth and epithelial to mesenchymal transition by activating hmgb2 in glioma. Int J Biochem Cell Biol. 93:25–31. 2017.PubMed/NCBI View Article : Google Scholar

28 

Wei H, Cui R, Bahr J, Zanesi N, Luo Z, Meng W, Liang G and Croce CM: Mir-130a deregulates pten and stimulates tumor growth. Cancer Res. 77:6168–6178. 2017.PubMed/NCBI View Article : Google Scholar

29 

Chen H, Yang Y, Wang J, Shen D, Zhao J and Yu Q: miR-130b-5p promotes proliferation, migration and invasion of gastric cancer cells via targeting RASAL1. Oncol Lett. 15:6361–6367. 2018.PubMed/NCBI View Article : Google Scholar

30 

Zhang HD, Jiang LH, Sun DW, Li J and Ji ZL: The role of mir-130a in cancer. Breast Cancer. 24:521–527. 2017.PubMed/NCBI View Article : Google Scholar

31 

Zhao G, Zhang JG, Shi Y, Qin Q, Liu Y, Wang B, Tian K, Deng SC, Li X, Zhu S, et al: miR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3. PLoS One. 8(e73803)2013.PubMed/NCBI View Article : Google Scholar

32 

Yu T, Cao R, Li S, Fu M, Ren L, Chen W, Zhu H, Zhan Q and Shi R: Mir-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells. BMC cancer. 15(29)2015.PubMed/NCBI View Article : Google Scholar

33 

Chang RM, Xu JF, Fang F, Yang H and Yang LY: Microrna-130b promotes proliferation and emt-induced metastasis via pten/p-Akt/hif-1alpha signaling. Tumour Biol. 37:10609–10619. 2016.PubMed/NCBI View Article : Google Scholar

34 

Zayzafoon M, Abdulkadir SA and McDonald JM: Notch signaling and ERK activation are important for the osteomimetic properties of prostate cancer bone metastatic cell lines. J Biol Chem. 279:3662–3670. 2004.PubMed/NCBI View Article : Google Scholar

35 

Carmen M, Ileana G, Stefano B, Oxana B, Bernard F, Carlo R, Rosario D and Cataldo A: PP242 counteracts glioblastoma cell proliferation, migration, invasiveness and stemness properties by inhibiting mTORC2/AKT. Front Cell Neurosci. 12(99)2018.PubMed/NCBI View Article : Google Scholar

36 

Slattery ML, Herrick JS, Lundgreen A, Fitzpatrick FA, Curtin K and Wolff RK: Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Carcinogenesis. 31:1604–1611. 2010.PubMed/NCBI View Article : Google Scholar

37 

Sun DM, Tang BF, Li ZX, Guo HB, Cheng JL, Song PP and Zhao X: miR-29c reduces the cisplatin resistance of non-small cell lung cancer cells by negatively regulating the PI3K/Akt pathway. Sci Rep. 8(8007)2018.PubMed/NCBI View Article : Google Scholar

38 

Zhou Y, Gu P, Li J, Li F, Zhu J, Gao P, Zang Y, Wang Y, Shan Y and Yang D: Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation. Oncol Rep. 38:2629–2636. 2017.PubMed/NCBI View Article : Google Scholar

39 

Xu S, Ge J, Zhang Z and Zhou W: miR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer. Biomed Pharmacother. 96:634–641. 2017.PubMed/NCBI View Article : Google Scholar

40 

Dhupkar P, Zhao H, Mujoo K, An Z and Zhang N: Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells. Biochem Biophys Rep. 8:382–388. 2016.PubMed/NCBI View Article : Google Scholar

41 

Zhang W, Hsu P, Zhong B, Guo S and Zhang C, Wang Y, Luo C, Zhan Y and Zhang C: MiR-34a enhances chondrocyte apoptosis, senescence and facilitates development of osteoarthritis by targeting DLL1 and regulating PI3K/AKT pathway. Cell Physiol Biochem. 48:1304–1316. 2018.PubMed/NCBI View Article : Google Scholar

42 

Miao Y, Zheng W, Li N, Su Z, Zhao L, Zhou H and Jia L: MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway. Sci Rep. 7(41942)2017.PubMed/NCBI View Article : Google Scholar

43 

Zhou D, Zhang L, Sun W, Guan W, Lin Q, Ren W, Zhang J and Xu G: Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer. Cell Signal. 35:197–207. 2017.PubMed/NCBI View Article : Google Scholar

44 

Elizabeth IH, Emma FS and Stack MS: With great age comes great metastatic ability: Ovarian cancer and the appeal of the aging peritoneal microenvironment. Cancers (Basel). 10(230)2018.PubMed/NCBI View Article : Google Scholar

45 

Shui Y, Yu X, Duan R, Bao Q, Wu J, Yuan H and Ma C: miR-130b-3p inhibits cell invasion and migration by targeting the Notch ligand Delta-like 1 in breast carcinoma. Gene. 609:80–87. 2017.PubMed/NCBI View Article : Google Scholar

46 

Duellman T, Chen X, Wakamiya R and Yang J: Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity. Biochem J. 475:1597–1610. 2018.PubMed/NCBI View Article : Google Scholar

47 

Murawala H, Patel S, Ranadive I, Desai I and Balakrishnan S: Variation in expression and activity pattern of mmp2 and mmp9 on different time scales in the regenerating caudal fin of poecilia latipinna. J Fish Biol. 92:1604–1619. 2018.PubMed/NCBI View Article : Google Scholar

48 

Sahay AS, Jadhav AT, Sundrani DP, Wagh GN, Mehendale SS and Joshi SR: Matrix metalloproteinases-2 (mmp-2) and matrix metalloproteinases-9 (mmp-9) are differentially expressed in different regions of normal and preeclampsia placentae. J Cell Biochem. 119:6657–6664. 2018.PubMed/NCBI View Article : Google Scholar

49 

Weiler J, Mohr M, Zänker KS and Dittmar T: Matrix metalloproteinase-9 (mmp9) is involved in the tnf-alpha-induced fusion of human m13sv1-cre breast epithelial cells and human mda-mb-435-pfdr1 cancer cells. Cell Commun Signal. 16(14)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jia L, Lei B, Gao H, Jia L, Luo D, Han J and Jia B: miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways. Exp Ther Med 23: 98, 2022.
APA
Jia, L., Lei, B., Gao, H., Jia, L., Luo, D., Han, J., & Jia, B. (2022). miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways. Experimental and Therapeutic Medicine, 23, 98. https://doi.org/10.3892/etm.2021.11021
MLA
Jia, L., Lei, B., Gao, H., Jia, L., Luo, D., Han, J., Jia, B."miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways". Experimental and Therapeutic Medicine 23.1 (2022): 98.
Chicago
Jia, L., Lei, B., Gao, H., Jia, L., Luo, D., Han, J., Jia, B."miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways". Experimental and Therapeutic Medicine 23, no. 1 (2022): 98. https://doi.org/10.3892/etm.2021.11021
Copy and paste a formatted citation
x
Spandidos Publications style
Jia L, Lei B, Gao H, Jia L, Luo D, Han J and Jia B: miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways. Exp Ther Med 23: 98, 2022.
APA
Jia, L., Lei, B., Gao, H., Jia, L., Luo, D., Han, J., & Jia, B. (2022). miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways. Experimental and Therapeutic Medicine, 23, 98. https://doi.org/10.3892/etm.2021.11021
MLA
Jia, L., Lei, B., Gao, H., Jia, L., Luo, D., Han, J., Jia, B."miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways". Experimental and Therapeutic Medicine 23.1 (2022): 98.
Chicago
Jia, L., Lei, B., Gao, H., Jia, L., Luo, D., Han, J., Jia, B."miR‑130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways". Experimental and Therapeutic Medicine 23, no. 1 (2022): 98. https://doi.org/10.3892/etm.2021.11021
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