Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2022 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2022 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Signal transduction mechanism of exosomes in diabetic complications (Review)

  • Authors:
    • Xueting Li
    • Shuo Shi
    • Dehuai Jing
    • Xinjian Li
    • Bin Zhang
    • Qingli Bie
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Digestive Endoscopy, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Nephrology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China
  • Article Number: 155
    |
    Published online on: December 17, 2021
       https://doi.org/10.3892/etm.2021.11078
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Exosomes are vesicles with a particle size of 30‑120 nm that are secreted by cells through exocytosis. The composition of an exosome includes a lipid bilayer and its internal package of biological molecules, such as proteins, ribonucleotides and deoxyribonucleotides. Diabetes is a chronic and refractory disease. The complications induced by high blood glucose have become a major problem in global public health and the pathogenesis of diabetic complications remains to be fully elucidated. In recent years, it has been gradually recognized that exosomes from different cell sources and their related molecules, particularly exosomal proteins and microRNAs, have an important role in the pathogenesis of diabetic complications, allowing for the exploration of the pathogenesis of diabetic complications from a molecular perspective. The present review summarizes the latest studies on exosomes from different cell sources in the pathogenesis of diabetic complications, which may provide novel targets for the prevention and treatment of diabetic complications.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, et al: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes atlas, 9th edition. Diabetes Res Clin Pract. 157(107843)2019.PubMed/NCBI View Article : Google Scholar

2 

Thomas CC and Philipson LH: Update on diabetes classification. Med Clin North Am. 99:1–16. 2015.PubMed/NCBI View Article : Google Scholar

3 

Müller G: Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab Syndr Obes. 5:247–282. 2012.PubMed/NCBI View Article : Google Scholar

4 

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, et al: Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity. Cell. 171:372–384.e12. 2017.PubMed/NCBI View Article : Google Scholar

5 

Lin J, Li J, Huang B, Liu J, Chen X, Chen XM, Xu YM, Huang LF and Wang XZ: Exosomes: Novel biomarkers for clinical diagnosis. ScientificWorldJournal. 2015(657086)2015.PubMed/NCBI View Article : Google Scholar

6 

Kalluri R and LeBleu VS: The biology, function, and biomedical applications of exosomes. Science. 367(eaau6977)2020.PubMed/NCBI View Article : Google Scholar

7 

Théry C, Zitvogel L and Amigorena S: Exosomes: Composition, biogenesis and function. Nat Rev Immunol. 2:569–579. 2002.PubMed/NCBI View Article : Google Scholar

8 

Doyle LM and Wang MZ: Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells. 8(727)2019.PubMed/NCBI View Article : Google Scholar

9 

Pegtel DM and Gould SJ: Exosomes. Annu Rev Biochem. 88:487–514. 2019.PubMed/NCBI View Article : Google Scholar

10 

Zhang J, Li S, Li L, Li M, Guo C, Yao J and Mi S: Exosome and exosomal microRNA: Trafficking, sorting, and function. Genomics Proteomics Bioinformatics. 13:17–24. 2015.PubMed/NCBI View Article : Google Scholar

11 

Lebovitz HE: Etiology and pathogenesis of diabetes mellitus. Pediatr Clin North Am. 31:521–530. 1984.PubMed/NCBI View Article : Google Scholar

12 

Kaul K, Tarr JM, Ahmad SI, Kohner EM and Chibber R: Introduction to diabetes mellitus. Adv Exp Med Biol. 771:1–11. 2012.PubMed/NCBI View Article : Google Scholar

13 

Forbes JM and Cooper ME: Mechanisms of diabetic complications. Physiol Rev. 93:137–188. 2013.PubMed/NCBI View Article : Google Scholar

14 

Jin J, Shi Y, Gong J, Zhao L, Li Y, He Q and Huang H: Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte. Stem Cell Res Ther. 10(95)2019.PubMed/NCBI View Article : Google Scholar

15 

Chang W and Wang J: Exosomes and their noncoding RNA cargo are emerging as new modulators for diabetes mellitus. Cells. 8(853)2019.PubMed/NCBI View Article : Google Scholar

16 

Castaño C, Novials A and Párrizas M: Exosomes and diabetes. Diabetes Metab Res Rev. 35(e3107)2019.PubMed/NCBI View Article : Google Scholar

17 

Kakleas K, Soldatou A, Karachaliou F and Karavanaki K: Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM). Autoimmun Rev. 14:781–797. 2015.PubMed/NCBI View Article : Google Scholar

18 

Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, et al: Primary human and rat β-cells release the intracellular autoantigens GAD65, IA-2, and proinsulin in exosomes together with cytokine-induced enhancers of immunity. Diabetes. 66:460–473. 2017.PubMed/NCBI View Article : Google Scholar

19 

Rahman MJ, Regn D, Bashratyan R and Dai YD: Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice. Diabetes. 63:1008–1020. 2014.PubMed/NCBI View Article : Google Scholar

20 

Garcia-Contreras M, Brooks RW, Boccuzzi L, Robbins PD and Ricordi C: Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus. Eur Rev Med Pharmacol Sci. 21:2940–2956. 2017.PubMed/NCBI

21 

Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, Gao J, Shirai Y, Kodama S, Asai Y, et al: MicroRNAs 106b and 222 improve hyperglycemia in a mouse model of insulin-deficient diabetes via pancreatic β-cell proliferation. EBioMedicine. 15:163–172. 2017.PubMed/NCBI View Article : Google Scholar

22 

Malone JI and Hansen BC: Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite? Pediatr Diabetes. 20:5–9. 2019.PubMed/NCBI View Article : Google Scholar

23 

Heydemann A: An overview of murine high fat diet as a model for type 2 diabetes mellitus. J Diabetes Res. 2016(2902351)2016.PubMed/NCBI View Article : Google Scholar

24 

Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, Zhang Q, Guo C, Zhang L and Wang Q: Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing m2 macrophages and beiging in white adipose tissue. Diabetes. 67:235–247. 2018.PubMed/NCBI View Article : Google Scholar

25 

Castaño C, Kalko S, Novials A and Párrizas M: Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice. Proc Natl Acad Sci USA. 115:12158–12163. 2018.PubMed/NCBI View Article : Google Scholar

26 

Brown AE and Walker M: Genetics of insulin resistance and the metabolic syndrome. Curr Cardiol Rep. 18(75)2016.PubMed/NCBI View Article : Google Scholar

27 

Sun Y, Shi H, Yin S, Ji C, Zhang X, Zhang B, Wu P, Shi Y, Mao F, Yan Y, et al: Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction. ACS Nano. 12:7613–7628. 2018.PubMed/NCBI View Article : Google Scholar

28 

Cole JB and Florez JC: Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 16:377–390. 2020.PubMed/NCBI View Article : Google Scholar

29 

Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, Hughes TM, Craft S, Freedman BI, Bowden DW, et al: Diabetic microvascular disease: An endocrine society scientific statement. J Clin Endocrinol Metab. 102:4343–4410. 2017.PubMed/NCBI View Article : Google Scholar

30 

Shen B, Liu J, Zhang F, Wang Y, Qin Y, Zhou Z, Qiu J and Fan Y: CCR2 positive exosome released by mesenchymal stem cells suppresses macrophage functions and alleviates ischemia/reperfusion-induced renal injury. Stem Cells Int. 2016(1240301)2016.PubMed/NCBI View Article : Google Scholar

31 

Liang X, Zhang L, Wang S, Han Q and Zhao RC: Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a. J Cell Sci. 129:2182–2189. 2016.PubMed/NCBI View Article : Google Scholar

32 

Chimenti MS, Ballanti E, Triggianese P and Perricone R: Vasculitides and the complement system: A comprehensive review. Clin Rev Allergy Immunol. 49:333–346. 2015.PubMed/NCBI View Article : Google Scholar

33 

Huang C, Fisher KP, Hammer SS, Navitskaya S, Blanchard GJ and Busik JV: Plasma exosomes contribute to microvascular damage in diabetic retinopathy by activating the classical complement pathway. Diabetes. 67:1639–1649. 2018.PubMed/NCBI View Article : Google Scholar

34 

Martínez-Castelao A, Navarro-González JF, Górriz JL and de Alvaro F: The concept and the epidemiology of diabetic nephropathy have changed in recent years. J Clin Med. 4:1207–1216. 2015.PubMed/NCBI View Article : Google Scholar

35 

Zhang L, Li R, Shi W, Liang X, Liu S, Ye Z, Yu C, Chen Y, Zhang B, Wang W, et al: NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 170:426–439. 2013.PubMed/NCBI View Article : Google Scholar

36 

Ioannou K: Diabetic nephropathy: Is it always there? Assumptions, weaknesses and pitfalls in the diagnosis. Hormones (Athens). 16:351–361. 2017.PubMed/NCBI View Article : Google Scholar

37 

Sakurai A, Ono H, Ochi A, Matsuura M, Yoshimoto S, Kishi S, Murakami T, Tominaga T, Nagai K, Abe H and Doi T: Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy. PLoS One. 14(e0216788)2019.PubMed/NCBI View Article : Google Scholar

38 

Abe H, Sakurai A, Ono H, Hayashi S, Yoshimoto S, Ochi A, Ueda S, Nishimura K, Shibata E, Tamaki M, et al: Urinary exosomal mRNA of WT1 as diagnostic and prognostic biomarker for diabetic nephropathy. J Med Invest. 65:208–215. 2018.PubMed/NCBI View Article : Google Scholar

39 

Kim H, Bae YU, Jeon JS, Noh H, Park HK, Byun DW, Han DC, Ryu S and Kwon SH: The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy. J Transl Med. 17(236)2019.PubMed/NCBI View Article : Google Scholar

40 

Calle P and Hotter G: Macrophage phenotype and fibrosis in diabetic nephropathy. Int J Mol Sci. 21(2806)2020.PubMed/NCBI View Article : Google Scholar

41 

Wang T, Zhu H, Yang S and Fei X: Let-7a-5p may participate in the pathogenesis of diabetic nephropathy through targeting HMGA2. Mol Med Rep. 19:4229–4237. 2019.PubMed/NCBI View Article : Google Scholar

42 

Ding Y and Choi ME: Regulation of autophagy by TGF-β: Emerging role in kidney fibrosis. Semin Nephrol. 34:62–71. 2014.PubMed/NCBI View Article : Google Scholar

43 

Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, et al: Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 21:556–563. 2010.PubMed/NCBI View Article : Google Scholar

44 

Jia Y, Zheng Z, Xue M, Zhang S, Hu F, Li Y, Yang Y, Zou M, Li S, Wang L, et al: Extracellular vesicles from albumin-induced tubular epithelial cells promote the M1 macrophage phenotype by targeting klotho. Mol Ther. 27:1452–1466. 2019.PubMed/NCBI View Article : Google Scholar

45 

Ding Y and Choi ME: Autophagy in diabetic nephropathy. J Endocrinol. 224:R15–R30. 2015.PubMed/NCBI View Article : Google Scholar

46 

Lu Q, Wang WW, Zhang MZ, Ma ZX, Qiu XR, Shen M and Yin XX: ROS induces epithelial-mesenchymal transition via the TGF-β1/PI3K/Akt/mTOR pathway in diabetic nephropathy. Exp Ther Med. 17:835–846. 2019.PubMed/NCBI View Article : Google Scholar

47 

Antonetti DA, Klein R and Gardner TW: Diabetic retinopathy. N Engl J Med. 366:1227–1239. 2012.PubMed/NCBI View Article : Google Scholar

48 

Mazzeo A, Beltramo E, Lopatina T, Gai C, Trento M and Porta M: Molecular and functional characterization of circulating extracellular vesicles from diabetic patients with and without retinopathy and healthy subjects. Exp Eye Res. 176:69–77. 2018.PubMed/NCBI View Article : Google Scholar

49 

Heng LZ, Comyn O, Peto T, Tadros C, Ng E, Sivaprasad S and Hykin PG: Diabetic retinopathy: Pathogenesis, clinical grading, management and future developments. Diabet Med. 30:640–650. 2013.PubMed/NCBI View Article : Google Scholar

50 

Shosha E, Xu Z, Narayanan SP, Lemtalsi T, Fouda AY, Rojas M, Xing J, Fulton D, Caldwell RW and Caldwell RB: Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1. Int J Mol Sci. 19(1215)2018.PubMed/NCBI View Article : Google Scholar

51 

Naruse R, Suetsugu M, Terasawa T, Ito K, Hara K, Takebayashi K, Morita K, Aso Y and Inukai T: Oxidative stress and antioxidative potency are closely associated with diabetic retinopathy and nephropathy in patients with type 2 diabetes. Saudi Med J. 34:135–141. 2013.PubMed/NCBI

52 

Zhang W, Dong X, Wang T and Kong Y: Exosomes derived from platelet-rich plasma mediate hyperglycemia-induced retinal endothelial injury via targeting the TLR4 signaling pathway. Exp Eye Res. 189(107813)2019.PubMed/NCBI View Article : Google Scholar

53 

Shao L, Zhang Y, Lan B, Wang J, Zhang Z, Zhang L, Xiao P, Meng Q, Geng YJ, Yu XY and Li Y: MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair. Biomed Res Int. 2017(4150705)2017.PubMed/NCBI View Article : Google Scholar

54 

Vujosevic S, Micera A, Bini S, Berton M, Esposito G and Midena E: Proteome analysis of retinal glia cells-related inflammatory cytokines in the aqueous humour of diabetic patients. Acta Ophthalmol. 94:56–64. 2016.PubMed/NCBI View Article : Google Scholar

55 

Liu C, Ge HM, Liu BH, Dong R, Shan K, Chen X, Yao MD, Li XM, Yao J, Zhou RM, et al: Targeting pericyte-endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction. Proc Natl Acad Sci USA. 116:7455–7464. 2019.PubMed/NCBI View Article : Google Scholar

56 

Dillmann WH: Diabetic cardiomyopathy. Circ Res. 124:1160–1162. 2019.PubMed/NCBI View Article : Google Scholar

57 

Bugger H and Abel ED: Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 57:660–671. 2014.PubMed/NCBI View Article : Google Scholar

58 

Jia G, Demarco VG and Sowers JR: Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 12:144–153. 2016.PubMed/NCBI View Article : Google Scholar

59 

Liu X, Song X, Lu J, Chen X, Liang E, Liu X, Zhang M, Zhang Y, Du Z and Zhao Y: Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice. Oncotarget. 7:61703–61715. 2016.PubMed/NCBI View Article : Google Scholar

60 

Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K and Olefsky JM: Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 121:4281–4288. 2011.PubMed/NCBI View Article : Google Scholar

61 

Tao S, Chen L, Song J, Zhu N, Song X, Shi R, Ge G and Zhang Y: Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats. Exp Ther Med. 18:729–734. 2019.PubMed/NCBI View Article : Google Scholar

62 

Wang X, Huang W, Liu G, Cai W, Millard RW, Wang Y, Chang J, Peng T and Fan GC: Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. J Mol Cell Cardiol. 74:139–150. 2014.PubMed/NCBI View Article : Google Scholar

63 

Hu J, Wang S, Xiong Z, Cheng Z, Yang Z, Lin J, Wang T, Feng X, Gao E, Wang H and Sun D: Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy. Biochim Biophys Acta Mol Basis Dis. 1864:3639–3649. 2018.PubMed/NCBI View Article : Google Scholar

64 

Quinaglia T, Oliveira DC, Matos-Souza JR and Sposito AC: Diabetic cardiomyopathy: Factual or factoid? Rev Assoc Med Bras (1992). 65:61–69. 2019.PubMed/NCBI View Article : Google Scholar

65 

Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW and Viswanathan V: Diabetic neuropathy. Nat Rev Dis Primers. 5(41)2019.PubMed/NCBI View Article : Google Scholar

66 

Ma J, Yu H, Liu J, Chen Y, Wang Q and Xiang L: Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. Eur J Pharmacol. 764:599–606. 2015.PubMed/NCBI View Article : Google Scholar

67 

Yin Z, Han Z, Hu T, Zhang S, Ge X, Huang S, Wang L, Yu J, Li W, Wang Y, et al: Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture. Brain Behav Immun. 83:270–282. 2020.PubMed/NCBI View Article : Google Scholar

68 

Feng Y, Chen L, Luo Q, Wu M, Chen Y and Shi X: Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation. Drug Des Devel Ther. 12:171–177. 2018.PubMed/NCBI View Article : Google Scholar

69 

Jia L, Chopp M, Wang L, Lu X, Szalad A and Zhang ZG: Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy. FASEB J. 32(fj201800597R)2018.PubMed/NCBI View Article : Google Scholar

70 

Alomar SY, Gheit R, Enan ET, El-Bayoumi KS, Shoaeir MZ, Elkazaz AY, Al Thagfan SS, Zaitone SA and El-Sayed RM: Novel mechanism for memantine in attenuating diabetic neuropathic pain in mice via downregulating the spinal HMGB1/TRL4/NF-kB inflammatory axis. Pharmaceuticals (Basel). 14(307)2021.PubMed/NCBI View Article : Google Scholar

71 

Chen Q, Zhang D, Wang L, Zhang Y, Chen H, Chen F and He Z: Effect of intermittent high glucose on oxygen-glucose deprivation/refurnish neuronal survival. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 31:61–66. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

72 

Bonomelli B, Martegani E and Colombo S: Lack of SNF1 induces localization of active Ras in mitochondria and triggers apoptosis in the yeast saccharomyces cerevisiae. Biochem Biophys Res Commun. 523:130–134. 2020.PubMed/NCBI View Article : Google Scholar

73 

Boulton AJ: Diabetic neuropathy and foot complications. Handb Clin Neurol. 126:97–107. 2014.PubMed/NCBI View Article : Google Scholar

74 

Noor S, Zubair M and Ahmad J: Diabetic foot ulcer-a review on pathophysiology, classification and microbial etiology. Diabetes Metab Syndr. 9:192–199. 2015.PubMed/NCBI View Article : Google Scholar

75 

Li X, Xie X, Lian W, Shi R, Han S, Zhang H, Lu L and Li M: Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med. 50:1–14. 2018.PubMed/NCBI View Article : Google Scholar

76 

Zhu B, Zhang L, Liang C, Liu B, Pan X, Wang Y, Zhang Y, Zhang Y, Xie W, Yan B, et al: Stem cell-derived exosomes prevent aging-induced cardiac dysfunction through a novel exosome/lncRNA MALAT1/NF-κB/TNF-α signaling pathway. Oxid Med Cell Longev. 2019(9739258)2019.PubMed/NCBI View Article : Google Scholar

77 

Harrell CR, Jovicic N, Djonov V, Arsenijevic N and Volarevic V: Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases. Cells. 8(1605)2019.PubMed/NCBI View Article : Google Scholar

78 

Li M, Wang T, Tian H, Wei G, Zhao L and Shi Y: Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model. Artif Cells Nanomed Biotechnol. 47:3793–3803. 2019.PubMed/NCBI View Article : Google Scholar

79 

Chen O, Donnelly CR and Ji RR: Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Curr Opin Neurobiol. 62:17–25. 2020.PubMed/NCBI View Article : Google Scholar : 
Qing L, Chen H, Tang J and Jia X: Exosomes and their MicroRNA cargo: New players in peripheral nerve regeneration. Neurorehabil Neural Repair 32, 765-776, 2018.

80 

Qing L, Chen H, Tang J and Jia X: Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration. Neurorehabil Neural Repair. 32:765–776. 2018.PubMed/NCBI View Article : Google Scholar

81 

Dalirfardouei R, Jamialahmadi K, Jafarian AH and Mahdipour E: Promising effects of exosomes isolated from menstrual blood-derived mesenchymal stem cell on wound-healing process in diabetic mouse model. J Tissue Eng Regen Med. 13:555–568. 2019.PubMed/NCBI View Article : Google Scholar

82 

DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, et al: Type 2 diabetes mellitus. Nat Rev Dis Primers. 1(15019)2015.PubMed/NCBI View Article : Google Scholar

83 

Cho JA, Yeo DJ, Son HY, Kim HW, Jung DS, Ko JK, Koh JS, Kim YN and Kim CW: Exosomes: A new delivery system for tumor antigens in cancer immunotherapy. Int J Cancer. 114:613–622. 2005.PubMed/NCBI View Article : Google Scholar

84 

Rani S, Ryan AE, Griffin MD and Ritter T: Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications. Mol Ther. 23:812–823. 2015.PubMed/NCBI View Article : Google Scholar

85 

Zhang Y, Bi J, Huang J, Tang Y, Du S and Li P: Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int J Nanomedicine. 15:6917–6934. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Shi S, Jing D, Li X, Zhang B and Bie Q: Signal transduction mechanism of exosomes in diabetic complications (Review). Exp Ther Med 23: 155, 2022.
APA
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., & Bie, Q. (2022). Signal transduction mechanism of exosomes in diabetic complications (Review). Experimental and Therapeutic Medicine, 23, 155. https://doi.org/10.3892/etm.2021.11078
MLA
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., Bie, Q."Signal transduction mechanism of exosomes in diabetic complications (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 155.
Chicago
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., Bie, Q."Signal transduction mechanism of exosomes in diabetic complications (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 155. https://doi.org/10.3892/etm.2021.11078
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Shi S, Jing D, Li X, Zhang B and Bie Q: Signal transduction mechanism of exosomes in diabetic complications (Review). Exp Ther Med 23: 155, 2022.
APA
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., & Bie, Q. (2022). Signal transduction mechanism of exosomes in diabetic complications (Review). Experimental and Therapeutic Medicine, 23, 155. https://doi.org/10.3892/etm.2021.11078
MLA
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., Bie, Q."Signal transduction mechanism of exosomes in diabetic complications (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 155.
Chicago
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., Bie, Q."Signal transduction mechanism of exosomes in diabetic complications (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 155. https://doi.org/10.3892/etm.2021.11078
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team