Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2022 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2022 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report

  • Authors:
    • Manuela Arbune
    • Anca-Adriana Arbune
    • Elena Niculet
    • Lucretia Anghel
    • Silvia Fotea
    • Alin Laurentiu Tatu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Department of Neurology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galați, Romania
    Copyright: © Arbune et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 175
    |
    Published online on: December 28, 2021
       https://doi.org/10.3892/etm.2021.11098
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Psoriasis can be paradoxically associated with human immunodeficiency virus (HIV) infection, having a prevalence similar to the general population but with a more severe evolution. In the genetically predisposed patients with the CW*0602 haplotype, HIV infection can be a triggering factor and a first sign of infection, and lesions can spontaneously remit with immune reconstruction after antiretroviral therapy. Our patient is a 34 year‑old male with recent HIV infection, in spite of being for over 10 years the partner of an HIV‑positive patient with whom the patient has two HIV‑positive children. The patient was diagnosed with psoriasis 7 years ago and was treated topically. The physical examination at HIV diagnosis was overall favorable, with skin findings compatible with disseminated vulgar psoriasis. Following antiretroviral treatment with Triumeq the patient had a favorable viral response, with complete viral suppression after 12 weeks, but the pre‑existent psoriasis lesions worsened. Methotrexate (MTX) treatment followed for 12 weeks, with partial improvement of psoriatic dermatitis. This medication was continued for 1 year, but the lesions reappeared, possibly due to treatment resistance. MTX treatment for psoriasis in the HIV‑infected patient was beneficial, but limited to one year, leaving biologics as possible treatment following therapy under strict monitoring for adverse effects, T‑lymphocyte CD4+ and viral levels.
View Figures

Figure 1

View References

1 

Michalek IM, Loring B and John SM: A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol. 31:205–212. 2017.PubMed/NCBI View Article : Google Scholar

2 

Batani A, Brănișteanu DE, Ilie MA, Boda D, Ianosi S, Ianosi G and Caruntu C: Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in vivo reflectance confocal microscopy. Exp Ther Med. 15:1241–1246. 2018.PubMed/NCBI View Article : Google Scholar

3 

Caruntu C, Boda D, Căruntu A, Rotaru M, Baderca F and Zurac S: In vivo imaging techniques for psoriatic lesions. Rom J Morphol Embryol. 55 (3 Suppl):S1191–S1196. 2014.PubMed/NCBI

4 

Dlova NC and Mosam A: Inflammatory noninfectious dermatoses of HIV. Dermatol Clin. 24439–448. (VI)2006.PubMed/NCBI View Article : Google Scholar

5 

Mamkin I, Mamkin A and Ramanan SV: HIV-associated psoriasis. Lancet Infect Dis. 7(496)2007.PubMed/NCBI View Article : Google Scholar

6 

Jordaan HF: Common skin and mucosal disorders in HIV/AIDS. S Afr Fam Pract. 50:14–23. 2008.

7 

Cedeno-Laurent F, Gómez-Flores M, Mendez N, Ancer-Rodríguez J, Bryant JL, Gaspari AA and Trujillo JR: New insights into HIV-1-primary skin disorders. J Int AIDS Soc. 14(5)2011.PubMed/NCBI View Article : Google Scholar

8 

Fife DJ, Waller JM, Jeffes EW and Koo JY: Unraveling the paradoxes of HIV-associated psoriasis: A review of T-cell subsets and cytokine profiles. Dermatol Online J. 13(4)2007.PubMed/NCBI

9 

Friedrich M, Krammig S, Henze M, Döcke WD, Sterry W and Asadullah K: Flow cytometric characterization of lesional T cells in psoriasis: Intracellular cytokine and surface antigen expression indicates an activated, memory/effector type 1 immunophenotype. Arch Dermatol Res. 292:519–521. 2000.PubMed/NCBI View Article : Google Scholar

10 

Mallon E and Bunker CB: HIV-associated psoriasis. AIDS Patient Care STDS. 14:239–246. 2000.PubMed/NCBI View Article : Google Scholar

11 

Niculet E, Radaschin DS, Nastase F, Draganescu M, Baroiu L, Miulescu M, Arbune M and Tatu AL: Influence of phytochemicals in induced psoriasis (review). Exp Ther Med. 20:3421–3424. 2020.PubMed/NCBI View Article : Google Scholar

12 

Cheaito MA, Khalifeh M, Jaafar B and Rizk N: Immune reconstitution inflammatory syndrome presenting as psoriasis after initiating antiretroviral therapy: A case-report. J Infect Dis Ther. 6(387)2018.

13 

Saketkoo LA and Espinoza LR: Impact of biologic agents on infectious diseases. Infect Dis Clin North Am. 20:931–961, viii. 2006.PubMed/NCBI View Article : Google Scholar

14 

Boda D, Negrei C, Nicolescu F and Badalau C: Assessment of some oxidative stress parameters in methotrexate treated psoriasis patients. Farmacia. 62:704–710. 2014.

15 

Caruntu C, Boda D, Dumitrascu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomark Med. 9:513–528. 2015.PubMed/NCBI View Article : Google Scholar

16 

Teh YC, Robinson S, Tan WC, Kwan Z and Tang MM: Psoriasis patients with human immunodeficiency virus infection: Data from the malaysian psoriasis registry. Malaysian J Dermatol. 46:1–10. 2021.

17 

Warren RB, Weatherhead SC, Smith CH, Exton LS, Mohd Mustapa MF, Kirby B and Yesudian PD: British association of dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease 2016. Br J Dermatol. 175:23–44. 2016.PubMed/NCBI View Article : Google Scholar

18 

Ezhilarasan D: Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms. Toxicology. 458(152840)2021.PubMed/NCBI View Article : Google Scholar

19 

Kaushik SB and Lebwohl MG: Psoriasis: Which therapy for which patient: Focus on special populations and chronic infections. J Am Acad Dermatol. 80:43–53. 2019.PubMed/NCBI View Article : Google Scholar

20 

Queirós N and Torres T: HIV-associated psoriasis. Actas Dermosifiliogr (Engl Ed). 109:303–311. 2018.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

21 

Gallitano SM, McDermott L, Brar K and Lowenstein E: Use of tumor necrosis factor (TNF) inhibitors in patients with HIV/AIDS. J Am Acad Dermatol. 74:974–980. 2016.PubMed/NCBI View Article : Google Scholar

22 

Bardazzi F, Magnano M, Campanati A, Loconsole F, Carpentieri A, Potenza C, Bernardini N, Di Lernia V, Carrera C, Raone B, et al: Biologic therapies in HIV-infected patients with psoriasis: An Italian experience. Acta Derm Venereol. 97:989–990. 2017.PubMed/NCBI View Article : Google Scholar

23 

Lambert JLW, Segaert S, Ghislain PD, Hillary T, Nikkels A, Willaert F, Lambert J and Speeckaert R: Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian evidence-based treatment advice in psoriasis; part 2). J Eur Acad Dermatol Venereol. 34:1914–1923. 2020.PubMed/NCBI View Article : Google Scholar

24 

Esposito M, Carubbi F, Giunta A, Alunno A, Giacomelli R and Fargnoli MC: Certolizumab pegol for the treatment of psoriatic arthritis and plaque psoriasis. Expert Rev Clin Immunol. 16:119–128. 2020.PubMed/NCBI View Article : Google Scholar

25 

Yang K, Oak ASW and Elewski BE: Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: A comprehensive review. Am J Clin Dermatol. 22:173–192. 2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Arbune M, Arbune A, Niculet E, Anghel L, Fotea S and Tatu AL: Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report. Exp Ther Med 23: 175, 2022.
APA
Arbune, M., Arbune, A., Niculet, E., Anghel, L., Fotea, S., & Tatu, A.L. (2022). Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report. Experimental and Therapeutic Medicine, 23, 175. https://doi.org/10.3892/etm.2021.11098
MLA
Arbune, M., Arbune, A., Niculet, E., Anghel, L., Fotea, S., Tatu, A. L."Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report". Experimental and Therapeutic Medicine 23.2 (2022): 175.
Chicago
Arbune, M., Arbune, A., Niculet, E., Anghel, L., Fotea, S., Tatu, A. L."Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report". Experimental and Therapeutic Medicine 23, no. 2 (2022): 175. https://doi.org/10.3892/etm.2021.11098
Copy and paste a formatted citation
x
Spandidos Publications style
Arbune M, Arbune A, Niculet E, Anghel L, Fotea S and Tatu AL: Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report. Exp Ther Med 23: 175, 2022.
APA
Arbune, M., Arbune, A., Niculet, E., Anghel, L., Fotea, S., & Tatu, A.L. (2022). Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report. Experimental and Therapeutic Medicine, 23, 175. https://doi.org/10.3892/etm.2021.11098
MLA
Arbune, M., Arbune, A., Niculet, E., Anghel, L., Fotea, S., Tatu, A. L."Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report". Experimental and Therapeutic Medicine 23.2 (2022): 175.
Chicago
Arbune, M., Arbune, A., Niculet, E., Anghel, L., Fotea, S., Tatu, A. L."Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report". Experimental and Therapeutic Medicine 23, no. 2 (2022): 175. https://doi.org/10.3892/etm.2021.11098
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team