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Review

Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review)

  • Authors:
    • Dragos Serban
    • Dumitru Cristinel Badiu
    • Dragos Davitoiu
    • Ciprian Tanasescu
    • Mihail Silviu Tudosie
    • Alexandru Dan Sabau
    • Ana Maria Dascalu
    • Corneliu Tudor
    • Simona Andreea Balasescu
    • Bogdan Socea
    • Daniel Ovidiu Costea
    • Anca Zgura
    • Andreea Cristina Costea
    • Laura Carina Tribus
    • Catalin Gabriel Smarandache
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Third Clinical Department, Faculty of Medicine, ‘Lucian Blaga’ University of Sibiu, 550169 Sibiu, Romania, Discipline of Clinical Toxicology, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Fourth Department of Surgery, Emergency University Hospital, 050098 Bucharest, Romania, Department of Clinical Surgical Disciplines I, Faculty of Medicine, Ovidius University, 900527 Constanta, Romania, Department of Radiology, Oncology, and Hematology, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020011 Bucharest, Romania, Department of Nephrology and Dialysis, ‘Diaverum’ Clinic, 900612 Constanta, Romania, Department of Internal Medicine Gastroenterology, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020011 Bucharest, Romania
  • Article Number: 187
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    Published online on: December 30, 2021
       https://doi.org/10.3892/etm.2021.11110
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Abstract

With the widespread introduction of laparoscopic cholecystectomy, the incidence of iatrogenic main bile duct lesions has significantly increased, with incidences ranging from 0.2 to 1.5% according to current studies. Although there are studies regarding the use of indocyanine green (ICG) for improved visualization of the biliary anatomy, there is no consensus on the dose, timing and optimal mode of administration, or the indications in which ICG provides a real benefit through increased safety in laparoscopic cholecystectomy (LC). A systematic review was performed on articles in English published until March 2021, which were identified on PubMed, Springer Nature, Elsevier and Scopus via specific mesh terms: ‘Indocyanine green’/‘near‑infrared fluorescence’ and ‘laparoscopic cholecystitis’. The most used method of administration of ICG was intravenously, only one study evaluated the efficiency of a near‑infrared cholangiogram (NIRC) when ICG was administered directly in the gallbladder. The majority of the studies included in the review used 2.5 mg of ICG administered within 1 h before imaging. The intensity of the NIRC fluorescence signal was revealed to depend on several factors, with obesity and inflammation as the most clinically significant. NIRC was reported to be a simple, feasible, safe and cost‑effective procedure, which may improve safety in difficult cases of LC. NIRC use in combination with white light has been demonstrated to be superior to white light alone in identifying extrahepatic biliary anatomy, thus decreasing the risk of intraoperative bile duct injuries (BDI). For its large‑scale use, data on a higher number of patients to confirm its clinical value and specific indications is required.
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Copy and paste a formatted citation
Spandidos Publications style
Serban D, Badiu DC, Davitoiu D, Tanasescu C, Tudosie MS, Sabau AD, Dascalu AM, Tudor C, Balasescu SA, Socea B, Socea B, et al: Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review). Exp Ther Med 23: 187, 2022.
APA
Serban, D., Badiu, D.C., Davitoiu, D., Tanasescu, C., Tudosie, M.S., Sabau, A.D. ... Smarandache, C.G. (2022). Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review). Experimental and Therapeutic Medicine, 23, 187. https://doi.org/10.3892/etm.2021.11110
MLA
Serban, D., Badiu, D. C., Davitoiu, D., Tanasescu, C., Tudosie, M. S., Sabau, A. D., Dascalu, A. M., Tudor, C., Balasescu, S. A., Socea, B., Costea, D. O., Zgura, A., Costea, A. C., Tribus, L. C., Smarandache, C. G."Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 187.
Chicago
Serban, D., Badiu, D. C., Davitoiu, D., Tanasescu, C., Tudosie, M. S., Sabau, A. D., Dascalu, A. M., Tudor, C., Balasescu, S. A., Socea, B., Costea, D. O., Zgura, A., Costea, A. C., Tribus, L. C., Smarandache, C. G."Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 187. https://doi.org/10.3892/etm.2021.11110
Copy and paste a formatted citation
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Spandidos Publications style
Serban D, Badiu DC, Davitoiu D, Tanasescu C, Tudosie MS, Sabau AD, Dascalu AM, Tudor C, Balasescu SA, Socea B, Socea B, et al: Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review). Exp Ther Med 23: 187, 2022.
APA
Serban, D., Badiu, D.C., Davitoiu, D., Tanasescu, C., Tudosie, M.S., Sabau, A.D. ... Smarandache, C.G. (2022). Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review). Experimental and Therapeutic Medicine, 23, 187. https://doi.org/10.3892/etm.2021.11110
MLA
Serban, D., Badiu, D. C., Davitoiu, D., Tanasescu, C., Tudosie, M. S., Sabau, A. D., Dascalu, A. M., Tudor, C., Balasescu, S. A., Socea, B., Costea, D. O., Zgura, A., Costea, A. C., Tribus, L. C., Smarandache, C. G."Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 187.
Chicago
Serban, D., Badiu, D. C., Davitoiu, D., Tanasescu, C., Tudosie, M. S., Sabau, A. D., Dascalu, A. M., Tudor, C., Balasescu, S. A., Socea, B., Costea, D. O., Zgura, A., Costea, A. C., Tribus, L. C., Smarandache, C. G."Systematic review of the role of indocyanine green near‑infrared fluorescence in safe laparoscopic cholecystectomy (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 187. https://doi.org/10.3892/etm.2021.11110
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