Open Access

Nanomedicine to modulate immunotherapy in cutaneous melanoma (Review)

  • Authors:
    • Simona Ruxandra Volovat
    • Serban Negru
    • Cati Raluca Stolniceanu
    • Constantin Volovat
    • Cristian Lungulescu
    • Dragos Scripcariu
    • Bogdan Mihail Cobzeanu
    • Cipriana Stefanescu
    • Cristina Grigorescu
    • Iolanda Augustin
    • Corina Lupascu Ursulescu
    • Cristian Constantin Volovat
  • View Affiliations

  • Published online on: March 23, 2021     https://doi.org/10.3892/etm.2021.9967
  • Article Number: 535
  • Copyright: © Volovat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer immunotherapy has shifted the paradigm in cancer treatment in recent years. Immune checkpoint blockage (ICB), the active cancer vaccination and chimeric antigen receptor (CAR) for T‑cell‑based adoptive cell transfer represent the main developments, achieving a surprising increased survival in patients included in clinical trials. In spite of these results, the current state‑of‑the‑art immunotherapy has its limitations in efficacy. The existence of an interdisciplinary interface involving current knowledge in biology, immunology, bioengineering and materials science represents important progress in increasing the effectiveness of immunotherapy in cancer. Cutaneous melanoma remains a difficult cancer to treat, in which immunotherapy is a major therapeutic option. In fact, enhancing immunotherapy is possible using sophisticated biomedical nanotechnology platforms of organic or inorganic materials or engineering various immune cells to enhance the immune system. In addition, biological devices have developed, changing the approach to and treatment results in melanoma. In this review, we present different modalities to modulate the immune system, as well as opportunities and challenges in melanoma treatment.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Volovat SR, Negru S, Stolniceanu CR, Volovat C, Lungulescu C, Scripcariu D, Cobzeanu BM, Stefanescu C, Grigorescu C, Augustin I, Augustin I, et al: Nanomedicine to modulate immunotherapy in cutaneous melanoma (Review). Exp Ther Med 21: 535, 2021
APA
Volovat, S.R., Negru, S., Stolniceanu, C.R., Volovat, C., Lungulescu, C., Scripcariu, D. ... Volovat, C.C. (2021). Nanomedicine to modulate immunotherapy in cutaneous melanoma (Review). Experimental and Therapeutic Medicine, 21, 535. https://doi.org/10.3892/etm.2021.9967
MLA
Volovat, S. R., Negru, S., Stolniceanu, C. R., Volovat, C., Lungulescu, C., Scripcariu, D., Cobzeanu, B. M., Stefanescu, C., Grigorescu, C., Augustin, I., Ursulescu, C. L., Volovat, C. C."Nanomedicine to modulate immunotherapy in cutaneous melanoma (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 535.
Chicago
Volovat, S. R., Negru, S., Stolniceanu, C. R., Volovat, C., Lungulescu, C., Scripcariu, D., Cobzeanu, B. M., Stefanescu, C., Grigorescu, C., Augustin, I., Ursulescu, C. L., Volovat, C. C."Nanomedicine to modulate immunotherapy in cutaneous melanoma (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 535. https://doi.org/10.3892/etm.2021.9967