Open Access

Expression of TMED3 is independently associated with colorectal cancer prognosis

  • Authors:
    • Rong-Fei Wang
    • Yong-Gang Hong
    • Li-Qiang Hao
    • Hai-Tao Yu
  • View Affiliations

  • Published online on: February 15, 2022     https://doi.org/10.3892/etm.2022.11215
  • Article Number: 286
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is the third most common cancer type and one of the deadliest cancers worldwide. Transmembrane p24 trafficking protein 3 (TMED3) has previously been indicated to suppress CRC metastasis, but its clinical significance has remained undetermined. In the present study, the expression of TMED3 was indicated to be elevated at the mRNA and protein levels in CRC tumor samples relative to that in para‑cancerous healthy tissue samples (P<0.05). Furthermore, Kaplan‑Meier survival analysis revealed a significant negative association between elevated TMED3 protein levels and overall survival of patients with CRC (P<0.001, log‑rank test). Multivariate Cox regression analysis additionally determined that elevated TMED3 expression in primary CRC tumors was an independent predictor of poor prognosis (P<0.05). These results revealed that elevated TMED3 expression in CRC was associated with patient survival outcomes, suggesting that TMED3 may be a potential prognostic biomarker for this cancer type.
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April-2022
Volume 23 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang R, Hong Y, Hao L and Yu H: Expression of TMED3 is independently associated with colorectal cancer prognosis. Exp Ther Med 23: 286, 2022
APA
Wang, R., Hong, Y., Hao, L., & Yu, H. (2022). Expression of TMED3 is independently associated with colorectal cancer prognosis. Experimental and Therapeutic Medicine, 23, 286. https://doi.org/10.3892/etm.2022.11215
MLA
Wang, R., Hong, Y., Hao, L., Yu, H."Expression of TMED3 is independently associated with colorectal cancer prognosis". Experimental and Therapeutic Medicine 23.4 (2022): 286.
Chicago
Wang, R., Hong, Y., Hao, L., Yu, H."Expression of TMED3 is independently associated with colorectal cancer prognosis". Experimental and Therapeutic Medicine 23, no. 4 (2022): 286. https://doi.org/10.3892/etm.2022.11215