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Expression of TMED3 is independently associated with colorectal cancer prognosis

  • Authors:
    • Rong-Fei Wang
    • Yong-Gang Hong
    • Li-Qiang Hao
    • Hai-Tao Yu
  • View Affiliations / Copyright

    Affiliations: Department of Tumor, Anus and Intestine, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, Department of Oncology, Lanxi People's Hospital, Lanxi, Zhejiang 321100, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 286
    |
    Published online on: February 15, 2022
       https://doi.org/10.3892/etm.2022.11215
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Abstract

Colorectal cancer (CRC) is the third most common cancer type and one of the deadliest cancers worldwide. Transmembrane p24 trafficking protein 3 (TMED3) has previously been indicated to suppress CRC metastasis, but its clinical significance has remained undetermined. In the present study, the expression of TMED3 was indicated to be elevated at the mRNA and protein levels in CRC tumor samples relative to that in para‑cancerous healthy tissue samples (P<0.05). Furthermore, Kaplan‑Meier survival analysis revealed a significant negative association between elevated TMED3 protein levels and overall survival of patients with CRC (P<0.001, log‑rank test). Multivariate Cox regression analysis additionally determined that elevated TMED3 expression in primary CRC tumors was an independent predictor of poor prognosis (P<0.05). These results revealed that elevated TMED3 expression in CRC was associated with patient survival outcomes, suggesting that TMED3 may be a potential prognostic biomarker for this cancer type.
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1 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014.PubMed/NCBI View Article : Google Scholar

2 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 383:1490–1502. 2014.PubMed/NCBI View Article : Google Scholar

3 

Welch HG and Robertson DJ: Colorectal cancer on the cecline - Why screening can't explain it all. N Engl J Med. 374:1605–1607. 2016.PubMed/NCBI View Article : Google Scholar

4 

Glunde K, Bhujwalla ZM and Ronen SM: Choline metabolism in malignant transformation. Nat Rev Cancer. 11:835–848. 2011.PubMed/NCBI View Article : Google Scholar

5 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

6 

Guo P, Huang ZL, Yu P and Li K: Trends in cancer mortality in China: An update. Ann Oncol. 23:2755–2762. 2012.PubMed/NCBI View Article : Google Scholar

7 

Connolly DJ, O'Neill LA and McGettrick AF: The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling. J Biol Chem. 288:5616–5623. 2013.PubMed/NCBI View Article : Google Scholar

8 

Strating JR, Hafmans TG and Martens GJ: Functional diversity among p24 subfamily members. Biol Cell. 101:207–219. 2009.PubMed/NCBI View Article : Google Scholar

9 

Zakariyah A, Hou W, Slim R and Jerome-Majewska L: TMED2/p24β1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines. Placenta. 33:214–219. 2012.PubMed/NCBI View Article : Google Scholar

10 

Liaunardy-Jopeace A, Bryant CE and Gay NJ: The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. Sci Signal. 7(ra70)2014.PubMed/NCBI View Article : Google Scholar

11 

Hou W and Jerome-Majewska LA: TMED2/emp24 is required in both the chorion and the allantois for placental labyrinth layer development. Dev Biol. 444:20–32. 2018.PubMed/NCBI View Article : Google Scholar

12 

Hasegawa H, Liu L and Nishimura M: Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting γ-cleavage of amyloid precursor protein. J Neurochem. 115:771–781. 2010.PubMed/NCBI View Article : Google Scholar

13 

Vainio P, Mpindi JP, Kohonen P, Fey V, Mirtti T, Alanen KA, Perälä M, Kallioniemi O and Iljin K: High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer. PLoS One. 7(e39801)2012.PubMed/NCBI View Article : Google Scholar

14 

Duquet A, Melotti A, Mishra S, Malerba M, Seth C, Conod A and Ruiz i Altaba A: A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12. EMBO Mol Med. 6:882–901. 2014.PubMed/NCBI View Article : Google Scholar

15 

Zheng H, Yang Y, Han J, Jiang WH, Chen C, Wang MC, Gao R, Li S, Tian T, Wang J, et al: TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling. Sci Rep. 6(37070)2016.PubMed/NCBI View Article : Google Scholar

16 

Strating JR and Martens GJ: The p24 family and selective transport processes at the ER-Golgi interface. Biol Cell. 101:495–509. 2009.PubMed/NCBI View Article : Google Scholar

17 

Füllekrug J, Suganuma T, Tang BL, Hong W, Storrie B and Nilsson T: Localization and recycling of gp27 (hp24gamma3): Complex formation with other p24 family members. Mol Biol Cell. 10:1939–1955. 1999.PubMed/NCBI View Article : Google Scholar

18 

Jenne N, Frey K, Brugger B and Wieland FT: Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. J Biol Chem. 277:46504–46511. 2002.PubMed/NCBI View Article : Google Scholar

19 

Jerome-Majewska LA, Achkar T, Luo L, Lupu F and Lacy E: The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Dev Biol. 341:154–166. 2010.PubMed/NCBI View Article : Google Scholar

20 

Montesinos JC, Sturm S, Langhans M, Hillmer S, Marcote MJ, Robinson DG and Aniento F: Coupled transport of Arabidopsis p24 proteins at the ER-Golgi interface. J Exp Bot. 63:4243–4261. 2012.PubMed/NCBI View Article : Google Scholar

21 

Denzel A, Otto F, Girod A, Pepperkok R, Watson R, Rosewell I, Bergeron JJ, Solari RC and Owen MJ: The p24 family member p23 is required for early embryonic development. Curr Biol. 10:55–58. 2000.PubMed/NCBI View Article : Google Scholar

22 

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA and McGettrick AF: The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. Nat Commun. 3(707)2012.PubMed/NCBI View Article : Google Scholar

23 

Wang X, Yang R, Jadhao SB, Yu D, Hu H, Glynn-Cunningham N, Sztalryd C, Silver KD and Gong DW: Transmembrane emp24 protein transport domain 6 is selectively expressed in pancreatic islets and implicated in insulin secretion and diabetes. Pancreas. 41:10–14. 2012.PubMed/NCBI View Article : Google Scholar

24 

Buechling T, Chaudhary V, Spirohn K, Weiss M and Boutros M: p24 proteins are required for secretion of Wnt ligands. EMBO Rep. 12:1265–1272. 2011.PubMed/NCBI View Article : Google Scholar

25 

Port F, Hausmann G and Basler K: A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. EMBO Rep. 12:1144–1152. 2011.PubMed/NCBI View Article : Google Scholar

26 

Li X, Wu Y, Shen C, Belenkaya TY, Ray L and Lin X: Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway. Biochem Biophys Res Commun. 463:483–489. 2015.PubMed/NCBI View Article : Google Scholar

27 

Mishra S, Bernal C, Silvano M, Anand S, Ruiz I and Altaba A and Altaba A: The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases. Oncogene. 38:5817–5837. 2019.PubMed/NCBI View Article : Google Scholar

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

29 

Tao QF, Yuan SX, Yang F, Yang S, Yang Y, Yuan JH, Wang ZG, Xu QG, Lin KY, Cai J, et al: Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma. Mol Cancer. 14(170)2015.PubMed/NCBI View Article : Google Scholar

30 

Petroski MD and Deshaies RJ: Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol. 6:9–20. 2005.PubMed/NCBI View Article : Google Scholar

31 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang R, Hong Y, Hao L and Yu H: Expression of TMED3 is independently associated with colorectal cancer prognosis. Exp Ther Med 23: 286, 2022.
APA
Wang, R., Hong, Y., Hao, L., & Yu, H. (2022). Expression of TMED3 is independently associated with colorectal cancer prognosis. Experimental and Therapeutic Medicine, 23, 286. https://doi.org/10.3892/etm.2022.11215
MLA
Wang, R., Hong, Y., Hao, L., Yu, H."Expression of TMED3 is independently associated with colorectal cancer prognosis". Experimental and Therapeutic Medicine 23.4 (2022): 286.
Chicago
Wang, R., Hong, Y., Hao, L., Yu, H."Expression of TMED3 is independently associated with colorectal cancer prognosis". Experimental and Therapeutic Medicine 23, no. 4 (2022): 286. https://doi.org/10.3892/etm.2022.11215
Copy and paste a formatted citation
x
Spandidos Publications style
Wang R, Hong Y, Hao L and Yu H: Expression of TMED3 is independently associated with colorectal cancer prognosis. Exp Ther Med 23: 286, 2022.
APA
Wang, R., Hong, Y., Hao, L., & Yu, H. (2022). Expression of TMED3 is independently associated with colorectal cancer prognosis. Experimental and Therapeutic Medicine, 23, 286. https://doi.org/10.3892/etm.2022.11215
MLA
Wang, R., Hong, Y., Hao, L., Yu, H."Expression of TMED3 is independently associated with colorectal cancer prognosis". Experimental and Therapeutic Medicine 23.4 (2022): 286.
Chicago
Wang, R., Hong, Y., Hao, L., Yu, H."Expression of TMED3 is independently associated with colorectal cancer prognosis". Experimental and Therapeutic Medicine 23, no. 4 (2022): 286. https://doi.org/10.3892/etm.2022.11215
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