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Article

Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages

  • Authors:
    • Ji-Won Park
    • Ok-Kyoung Kwon
    • Hyung Won Ryu
    • Jin-Hyub Paik
    • Imam Paryanto
    • Prasetyawan Yuniato
    • Sangho Choi
    • Sei-Ryang Oh
    • Kyung-Seop Ahn
  • View Affiliations / Copyright

    Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea, International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Yuseong-gu, Daejeon 34141, Republic of Korea, Center for Pharmaceutical and Medical Technology, The Agency for the Assessment and Application of Technology (BPPT), Kawasan Puspiptek Serpong, Tangerang, Banten 15314, Indonesia
  • Pages: 3709-3716
    |
    Published online on: March 12, 2018
       https://doi.org/10.3892/ijmm.2018.3559
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Abstract

Passiflora foetida L. (Passifloraceae), a perennial climber in general, is used for treating many ailments in conventional medicine. In this study, the anti-inflammatory effect of methanolic extracts of P. foetida L. (PFME) and the involvement of nuclear factor-κB (NF-κB) signalling in the regulation of inflammation were investigated. PFME prevented the production of prostaglandin E2 (PGE2) and the expression of inducible cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced macrophage cells. Additionally, PFME reduced the release of pro-inflammatory cytokines. Moreover, in LPS-induced RAW264.7 cells, the phosphorylation of MAPKs (ERK1/2, p38 and JNK) was suppressed by PFME. Furthermore, PFME inhibited the NF-κB activation induced by LPS, which was associated with nuclear p65 levels with the abrogation of IκBα degradation and subsequent decreases. These results indicated that the PFME inhibited the LPS-induced inflammatory and oxidative responses. Therefore, we propose that the PFME may be therapeutic for treating inflammatory diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Park J, Kwon O, Ryu HW, Paik J, Paryanto I, Yuniato P, Choi S, Oh S and Ahn K: Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages. Int J Mol Med 41: 3709-3716, 2018.
APA
Park, J., Kwon, O., Ryu, H.W., Paik, J., Paryanto, I., Yuniato, P. ... Ahn, K. (2018). Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages. International Journal of Molecular Medicine, 41, 3709-3716. https://doi.org/10.3892/ijmm.2018.3559
MLA
Park, J., Kwon, O., Ryu, H. W., Paik, J., Paryanto, I., Yuniato, P., Choi, S., Oh, S., Ahn, K."Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages". International Journal of Molecular Medicine 41.6 (2018): 3709-3716.
Chicago
Park, J., Kwon, O., Ryu, H. W., Paik, J., Paryanto, I., Yuniato, P., Choi, S., Oh, S., Ahn, K."Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages". International Journal of Molecular Medicine 41, no. 6 (2018): 3709-3716. https://doi.org/10.3892/ijmm.2018.3559
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Kwon O, Ryu HW, Paik J, Paryanto I, Yuniato P, Choi S, Oh S and Ahn K: Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages. Int J Mol Med 41: 3709-3716, 2018.
APA
Park, J., Kwon, O., Ryu, H.W., Paik, J., Paryanto, I., Yuniato, P. ... Ahn, K. (2018). Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages. International Journal of Molecular Medicine, 41, 3709-3716. https://doi.org/10.3892/ijmm.2018.3559
MLA
Park, J., Kwon, O., Ryu, H. W., Paik, J., Paryanto, I., Yuniato, P., Choi, S., Oh, S., Ahn, K."Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages". International Journal of Molecular Medicine 41.6 (2018): 3709-3716.
Chicago
Park, J., Kwon, O., Ryu, H. W., Paik, J., Paryanto, I., Yuniato, P., Choi, S., Oh, S., Ahn, K."Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages". International Journal of Molecular Medicine 41, no. 6 (2018): 3709-3716. https://doi.org/10.3892/ijmm.2018.3559
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