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S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy

  • Authors:
    • Li‑Jun Yue
    • Xi‑Yu Zhu
    • Rui‑Sha Li
    • Hui‑Jing Chang
    • Bing Gong
    • Chong‑Chong Tian
    • Chang Liu
    • Yun‑Xing Xue
    • Qing Zhou
    • Tian‑Shu Xu
    • Dong‑Jin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Yue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1943-1951
    |
    Published online on: September 26, 2019
       https://doi.org/10.3892/ijmm.2019.4351
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Abstract

S‑allyl‑cysteine sulfoxide (alliin) is the main organosulfur component of garlic and its preparations. The present study aimed to examine the protective effect of alliin on cardiac function and the underlying mechanism in a mouse model of myocardial infarction (MI). Notably, alliin treatment preserved heart function, attenuated the area of infarction in the myocardium of mice and reduced lesions in the myocardium, including cardiomyocyte fibrosis and death. Further mechanistic experiments revealed that alliin inhibited necroptosis but promoted autophagy in vitro and in vivo. Cell viability assays showed that alliin dose‑dependently reduced the necroptotic index and inhibited the expression of necroptosis‑related receptor‑interacting protein 1, receptor‑interacting protein 3 and tumor necrosis factor receptor‑associated factor 2, whereas the levels of Beclin 1 and microtubule‑associated protein 1 light chain 3, which are associated with autophagy, exhibited an opposite trend upon treatment with alliin. In addition, the level of peroxisome proliferator‑activated receptor γ was increased by alliin. Collectively, these findings demonstrate that alliin has the potential to protect cardiomyocytes from necroptosis following MI and that this protective effect occurs via the enhancement of autophagy.
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Copy and paste a formatted citation
Spandidos Publications style
Yue LJ, Zhu XY, Li RS, Chang HJ, Gong B, Tian CC, Liu C, Xue YX, Zhou Q, Xu TS, Xu TS, et al: S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy. Int J Mol Med 44: 1943-1951, 2019.
APA
Yue, L., Zhu, X., Li, R., Chang, H., Gong, B., Tian, C. ... Wang, D. (2019). S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy. International Journal of Molecular Medicine, 44, 1943-1951. https://doi.org/10.3892/ijmm.2019.4351
MLA
Yue, L., Zhu, X., Li, R., Chang, H., Gong, B., Tian, C., Liu, C., Xue, Y., Zhou, Q., Xu, T., Wang, D."S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy". International Journal of Molecular Medicine 44.5 (2019): 1943-1951.
Chicago
Yue, L., Zhu, X., Li, R., Chang, H., Gong, B., Tian, C., Liu, C., Xue, Y., Zhou, Q., Xu, T., Wang, D."S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy". International Journal of Molecular Medicine 44, no. 5 (2019): 1943-1951. https://doi.org/10.3892/ijmm.2019.4351
Copy and paste a formatted citation
x
Spandidos Publications style
Yue LJ, Zhu XY, Li RS, Chang HJ, Gong B, Tian CC, Liu C, Xue YX, Zhou Q, Xu TS, Xu TS, et al: S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy. Int J Mol Med 44: 1943-1951, 2019.
APA
Yue, L., Zhu, X., Li, R., Chang, H., Gong, B., Tian, C. ... Wang, D. (2019). S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy. International Journal of Molecular Medicine, 44, 1943-1951. https://doi.org/10.3892/ijmm.2019.4351
MLA
Yue, L., Zhu, X., Li, R., Chang, H., Gong, B., Tian, C., Liu, C., Xue, Y., Zhou, Q., Xu, T., Wang, D."S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy". International Journal of Molecular Medicine 44.5 (2019): 1943-1951.
Chicago
Yue, L., Zhu, X., Li, R., Chang, H., Gong, B., Tian, C., Liu, C., Xue, Y., Zhou, Q., Xu, T., Wang, D."S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy". International Journal of Molecular Medicine 44, no. 5 (2019): 1943-1951. https://doi.org/10.3892/ijmm.2019.4351
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