Update on current views and advances on RSV infection (Review)

Mammas,Ioannis   N.; Drysdale,Simon   B.; Rath,Barbara; Theodoridou,Maria; Papaioannou,Georgia; Papatheodoropoulou,Alexia; Koutsounaki,Eirini; Koutsaftiki,Chryssie; Kozanidou,Eleftheria; Achtsidis,Vassilis; Korovessi,Paraskevi; Chrousos,George   P.; Spandidos,Demetrios   A.

doi:10.3892/ijmm.2020.4641

Update on current views and advances on RSV infection (Review)

Authors:
- Ioannis N. Mammas
- Simon B. Drysdale
- Barbara Rath
- Maria Theodoridou
- Georgia Papaioannou
- Alexia Papatheodoropoulou
- Eirini Koutsounaki
- Chryssie Koutsaftiki
- Eleftheria Kozanidou
- Vassilis Achtsidis
- Paraskevi Korovessi
- George P. Chrousos
- Demetrios A. Spandidos
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Affiliations: Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, St. George's, University of London, London SW17 0RE, UK, Vienna Vaccine Safety Initiative, D‑10437 Berlin, Germany, First Department of Paediatrics, University of Athens School of Medicine, 11527 Athens, Greece, Department of Paediatric Radiology, ‘Mitera’ Children's Hospital, 15123 Athens, Greece, Paediatric Intensive Care Unit (PICU), ‘Aglaia Kyriakou’ Children's Hospital, 11527 Athens, Greece, Neonatal Department, ‘Alexandra’ Maternity Hospital, 15123 Athens, Greece, Paediatric Intensive Care Unit (PICU), ‘Penteli’ Children's Hospital, 15236 Penteli, Greece, 2nd Department of Internal Medicine, ‘St Panteleimon’ General Hospital of Nikaia, 18454 Piraeus, Greece, Department of Ophthalmology, Royal Cornwall Hospitals, Cornwall TR1 3LQ, UK, Department of Paediatrics, ‘Penteli’ Children's Hospital, 15236 Penteli, Greece
Published online on: June 15, 2020 https://doi.org/10.3892/ijmm.2020.4641
Pages: 509-520
Copyright: © Mammas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision medicine in modern paediatrics and several clinical trials are currently performed in the prevention and management of RSV infection. A new taxonomic terminology for RSV was recently adopted, while the diagnostic and omics techniques have revealed new modalities in the early identification of RSV infections and for better understanding of the disease pathogenesis. Coordinated clinical and research efforts constitute an important step in limiting RSV global predominance, improving epidemiological surveillance, and advancing neonatal and paediatric care. This review article presents the key messages of the plenary lectures, oral presentations and posters of the ‘5th workshop on paediatric virology’ (Sparta, Greece, 12th October 2019) organized by the Paediatric Virology Study Group, focusing on recent advances in the epidemiology, pathogenesis, diagnosis, prognosis, clinical management and prevention of RSV infection in childhood.

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