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Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis

  • Authors:
    • Guanghua Qin
    • Xuejian Wu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 92
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    Published online on: March 30, 2021
       https://doi.org/10.3892/ijmm.2021.4925
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Abstract

Osteosarcoma (OS), also known as bone cancer, is a threat to the lives of millions of adolescents worldwide. Although dedicated efforts have been invested in reducing the mortality rate of this bone cancer, the research community is yet to find the exact causes of OS. Thus, the present research aimed to study the association between circular RNA circ_0032463 and OS progression. The impact of circ_0032463 on cells with OS was first evaluated using reverse transcription‑quantitative PCR. This evaluation was followed by the assessment of cell proliferation, viability, apoptosis, invasion and adhesion using BrdU, Cell Counting Kit‑8, flow cytometry, Transwell and cell adhesion assays, respectively. RNA pull‑down, RNA immunoprecipitation chip and dual‑luciferase reporter systems were utilized to investigate the relationship between circ_0032463, microRNA (miR)‑330‑3p and Pinin desmosome associated protein (PNN) in OS. The findings indicated that circ_0032463 and PNN were highly expressed in OS tissues and OS cell lines, and that they facilitated cell proliferation, viability, invasion and adhesion, but attenuated cell apoptosis in OS cells. The low expression of miR‑330‑3p suppressed OS development. It was also noted that circ_0032463 inhibited miR‑330‑3p to upregulate PNN expression. In conclusion, this study confirmed that by regulating the miR‑330‑3p/PNN axis, circular RNA circ_0032463 could function as a tumor enhancer in cells with OS.
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1 

Rickel K, Fang F and Tao J: Molecular genetics of osteosarcoma. Bone. 102:69–79. 2017. View Article : Google Scholar :

2 

Savage SA and Mirabello L: Using epidemiology and genomics to understand osteosarcoma etiology. Sarcoma. 2011:5481512011. View Article : Google Scholar : PubMed/NCBI

3 

Isakoff MS, Bielack SS, Meltzer P and Gorlick R: Osteosarcoma: Current treatment and a collaborative pathway to success. J Clin Oncol. 33:3029–3035. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Otoukesh B, Boddouhi B, Moghtadaei M, Kaghazian P and Kaghazian M: Novel molecular insights and new therapeutic strategies in osteosarcoma. Cancer Cell Int. 18:1582018. View Article : Google Scholar : PubMed/NCBI

5 

Bishop MW, Janeway KA and Gorlick R: Future directions in the treatment of osteosarcoma. Curr Opin Pediatr. 28:26–33. 2016. View Article : Google Scholar :

6 

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB and Kjems J: The biogenesis, biology and characterization of circular RNAs. Nature Rev Genet. 20:675–691. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Kristensen LS, Hansen TB, Venø MT and Kjems J: Circular RNAs in cancer: opportunities and challenges in the field. Oncogene. 37:555–565. 2018. View Article : Google Scholar :

9 

Wang C, Ren M, Zhao X, Wang A and Wang J: Emerging roles of circular RNAs in osteosarcoma. Med Sci Monit. 24:7043–7050. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Y and Li J, Wang Y, Jing J and Li J: The roles of circular RNAs in osteosarcoma. Med Sci Monit. 25:6378–6382. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Li H, Lan M, Liao X, Tang Z and Yang C: Circular RNA cir-ITCH promotes osteosarcoma migration and invasion through cir-ITCH/miR-7/EGFR pathway. Technol Cancer Res Treat. Jan 21–2020.Epub ahead of print. View Article : Google Scholar

12 

Chen L, Shan Y, Zhang H, Wang H and Chen Y: Up-regulation of Hsa_circ_0008792 inhibits osteosarcoma cell invasion and migration and promotes apoptosis by regulating Hsa-miR-711/ZFP1. OncoTargets Ther. 13:2173–2181. 2020. View Article : Google Scholar

13 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Liang M, Huang G, Liu Z, Wang Q, Yu Z, Liu Z, Lin H, Li M, Zhou X and Zheng Y: Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195/GPRC5A signalling. Cell Prolif. 52:e126612019. View Article : Google Scholar : PubMed/NCBI

15 

Rong X, Gao W, Yang X and Guo J: Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling. Life Sci. 235:1167852019. View Article : Google Scholar : PubMed/NCBI

16 

Yao J, Zhang C, Chen Y and Gao S: Downregulation of circular RNA circ-LDLRAD3 suppresses pancreatic cancer progression through miR-137-3p/PTN axis. Life Sci. 239:1168712019. View Article : Google Scholar : PubMed/NCBI

17 

Zhang CL, Li LB, She C, Xie Y, Ge DW and Dong QR: MiR-299-5p targets cell cycle to promote cell proliferation and progression of osteosarcoma. Eur Rev Med Pharmacol Sci. 22:2606–2613. 2018.PubMed/NCBI

18 

Lv DB, Zhang JY, Gao K, Yu ZH, Sheng WC, Yang G and Gao YZ: MicroRNA-765 targets MTUS1 to promote the progression of osteosarcoma via mediating ERK/EMT pathway. Eur Rev Med Pharmacol Sci. 23:4618–4628. 2019.PubMed/NCBI

19 

Loughlin V and Beniwal JS: Post-traumatic brachial artery aneurysm and arteriovenous fistulae. J Cardiovasc Surg (Torino). 29:570–571. 1988.

20 

Liu G, Huang K, Jie Z, Wu Y, Chen J, Chen Z, Fang X and Shen S: CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells. Mol Cancer. 17:1702018. View Article : Google Scholar : PubMed/NCBI

21 

Xu R, Feng F, Yu X, Liu Z and Lao L: LncRNA SNHG4 promotes tumour growth by sponging miR-224-3p and predicts poor survival and recurrence in human osteosarcoma. Cell Proliferation. 51:e125152018. View Article : Google Scholar : PubMed/NCBI

22 

He M, Shen P, Qiu C and Wang J: miR-627-3p inhibits osteosarcoma cell proliferation and metastasis by targeting PTN. Aging. 11:5744–5756. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Jin Z, Jia B, Tan L and Liu Y: miR-330-3p suppresses liver cancer cell migration by targeting MAP2K1. Oncol Lett. 18:314–320. 2019.PubMed/NCBI

24 

Guan A, Wang H, Li X, Xie H, Wang R, Zhu Y and Li R: MiR-330-3p inhibits gastric cancer progression through targeting MSI1. Am J Transl Res. 8:4802–4811. 2016.PubMed/NCBI

25 

Zheng Z, Bao F, Chen X, Huang H and Zhang X: MicroRNA-330-3p expression indicates good prognosis and suppresses cell proliferation by targeting bmi-1 in osteosarcoma. Cell Physiol Biochem. 46:442–450. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Mini E, Lapucci A, Perrone G, D'Aurizio R, Napoli C, Brugia M, Landini I, Tassi R, Picariello L, Simi L, et al: RNA sequencing reveals PNN and KCNQ1OT1 as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy. Int J Cancer. 145:2580–2593. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Kwok JS, Choi PW, Liu M, Yang J, Singh J, Ng SK, Welch WR, Muto MG, Tsui SK, et al: Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells. Oncotarget. 7:11397–11411. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Wei Z, Ma W, Qi X, Zhu X, Wang Y, Xu Z, Luo J, Wang D, Guo W, Li X, et al: Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway. Oncotarget. 7:29429–29439. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Yang X, Sun D, Dong C, Tian Y, Gao Z and Wang L: Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis. Oncotarget. 7:39694–39704. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Paoloni M, Davis S, Lana S, Withrow S, Sangiorgi L, Picci P, Hewitt S, Triche T, Meltzer P and Khanna C: Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics. 10:6252009. View Article : Google Scholar : PubMed/NCBI

31 

Sadikovic B, Yoshimoto M, Chilton-MacNeill S, Thorner P, Squire JA and Zielenska M: Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling. Human Mol Genet. 18:1962–1975. 2009. View Article : Google Scholar

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

33 

Wang H, Liu L and Fang S: MicroRNA-330-5p inhibits osteosarcoma cell growth and invasion by targeting the proto-oncogene survivin. Mol Med Rep. 20:2236–2244. 2019.PubMed/NCBI

34 

Caudill JS and Arndt CA: Diagnosis and management of bone malignancy in adolescence. Adolesc Med State Art Rev. 18:62–78. ix2007.

35 

Zhang H, Yan J, Lang X and Zhuang Y: Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/β-catenin signaling pathway. Oncol Lett. 16:5856–5862. 2018.PubMed/NCBI

36 

Zhang Z, Pu F, Wang B, Wu Q, Liu J and Shao Z: Hsa_ circ_0000285 functions as a competitive endogenous RNA to promote osteosarcoma progression by sponging hsa-miRNA-599. Gene therapy. 27:186–195. 2020. View Article : Google Scholar

37 

Liu X, Zhong Y, Li J and Shan A: Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448. Oncotarget. 8:114829–114838. 2017. View Article : Google Scholar

38 

Wu Z, Shi W and Jiang C: Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/β-catenin pathway by regulating miR-1205/APC2 axis. Biochem Biophys Res Commun. 502:465–471. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Qian L, Yu S, Chen Z, Meng Z, Huang S and Wang P: The emerging role of circRNAs and their clinical significance in human cancers. Biochimica Biophys Acta Rev Cancer. 1870:247–260. 2018. View Article : Google Scholar

40 

Chen BJ, Byrne FL, Takenaka K, Modesitt SC, Olzomer EM, Mills JD, Farrell R, Hoehn KL and Janitz M: Analysis of the circular RNA transcriptome in endometrial cancer. Oncotarget. 9:5786–5796. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Nie WB, Zhao LM, Guo R, Wang MX and Ye FG: Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma. Eur Rev Med Pharmacol Sci. 22:6239–6244. 2018.PubMed/NCBI

42 

Wang L, Du ZG, Huang H, Li FS, Li GS and Xu SN: Circ-0003998 promotes cell proliferative ability and invasiveness by binding to miR-197-3p in osteosarcoma. Eur Rev Med Pharmacol Sci. 23:10638–10646. 2019.PubMed/NCBI

43 

Dong W, Bi J, Liu H, Yan D, He Q, Zhou Q, Wang Q, Xie R, Su Y, Yang M, et al: Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis. Mol Cancer. 18:952019. View Article : Google Scholar : PubMed/NCBI

44 

Yao Y, Zuo J and Wei Y: Targeting of TRX2 by miR-330-3p in melanoma inhibits proliferation. Biomed Pharmacother. 107:1020–1029. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Tang T, Yang L, Cao Y, Wang M, Zhang S, Gong Z, Xiong F, He Y, Zhou Y, Liao Q, et al: LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. Mol Oncol. 14:2251–2270. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Wei Z, Ma W, Qi X, Zhu X, Wang Y, Xu Z, Luo J, Wang D, Guo W, Li X, et al: Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway. Oncotarget. 7:29429–29439. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Shi Y, Hunt ME and Sugrue SP: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol Cell Biol. 24:10223–10235. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Joo JH, Alpatov R, Munguba GC, Jackson MR, Hunt ME and Sugrue SP: Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells. Mol Vision. 11:133–142. 2005.

49 

Ritter J and Bielack SS: Osteosarcoma. Ann Oncol. 21(Suppl 7): vii320–vii325. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qin G and Wu X: Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis. Int J Mol Med 47: 92, 2021.
APA
Qin, G., & Wu, X. (2021). Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis. International Journal of Molecular Medicine, 47, 92. https://doi.org/10.3892/ijmm.2021.4925
MLA
Qin, G., Wu, X."Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis". International Journal of Molecular Medicine 47.5 (2021): 92.
Chicago
Qin, G., Wu, X."Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis". International Journal of Molecular Medicine 47, no. 5 (2021): 92. https://doi.org/10.3892/ijmm.2021.4925
Copy and paste a formatted citation
x
Spandidos Publications style
Qin G and Wu X: Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis. Int J Mol Med 47: 92, 2021.
APA
Qin, G., & Wu, X. (2021). Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis. International Journal of Molecular Medicine, 47, 92. https://doi.org/10.3892/ijmm.2021.4925
MLA
Qin, G., Wu, X."Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis". International Journal of Molecular Medicine 47.5 (2021): 92.
Chicago
Qin, G., Wu, X."Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis". International Journal of Molecular Medicine 47, no. 5 (2021): 92. https://doi.org/10.3892/ijmm.2021.4925
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