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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Article

Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling

  • Authors:
    • Xiaolong Wang
    • Ning Zhang
    • Qiang Huo
    • Mingjuan Sun
    • Shangge Lv
    • Qifeng Yang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 321-328
    |
    Published online on: May 20, 2013
       https://doi.org/10.3892/ijo.2013.1947
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Abstract

Estrogen receptor α (ERα) has been reported to play a critical role in promoting the growth of breast tumor cells. In the present study, we explored the effect of Huaier extract on estrogen receptor α signaling in breast cancer cell lines. Our data demonstrated that Huaier extract effectively inhibited the proliferation of the MCF-7, T47D and ZR-75-1 human breast cancer cell lines. For the mechanism analysis, we demonstrated that Huaier extract significantly reduced the mRNA and protein levels of ERα in all three ERα-positive cell lines. The downregulation of ERα protein levels was correlated with activation of the proteasomes. We demonstrated that Huaier extract markedly decreased the expression of both ERα and its downstream genes, inhibited the estrogen-stimulated proliferation and reversed the estrogen-induced activation of the nuclear factor κB (NFκB) pathway. Our study provides evidence that Huaier extract is a novel estrogen receptor modulator and is a promising drug for the prevention and treatment of ERα-positive human breast cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Zhang N, Huo Q, Sun M, Lv S and Yang Q: Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling. Int J Oncol 43: 321-328, 2013.
APA
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., & Yang, Q. (2013). Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling. International Journal of Oncology, 43, 321-328. https://doi.org/10.3892/ijo.2013.1947
MLA
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., Yang, Q."Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling". International Journal of Oncology 43.1 (2013): 321-328.
Chicago
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., Yang, Q."Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling". International Journal of Oncology 43, no. 1 (2013): 321-328. https://doi.org/10.3892/ijo.2013.1947
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhang N, Huo Q, Sun M, Lv S and Yang Q: Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling. Int J Oncol 43: 321-328, 2013.
APA
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., & Yang, Q. (2013). Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling. International Journal of Oncology, 43, 321-328. https://doi.org/10.3892/ijo.2013.1947
MLA
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., Yang, Q."Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling". International Journal of Oncology 43.1 (2013): 321-328.
Chicago
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., Yang, Q."Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling". International Journal of Oncology 43, no. 1 (2013): 321-328. https://doi.org/10.3892/ijo.2013.1947
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