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Article

VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review)

Corrigendum in: /10.3892/ijo.2016.3636
  • Authors:
    • Samanta Taurone
    • Filippo Galli
    • Alberto Signore
    • Enzo Agostinelli
    • Rudi A.J.O. Dierckx
    • Antonio Minni
    • Marcella Pucci
    • Marco Artico
  • View Affiliations / Copyright

    Affiliations: IRCCS-G.B. Bietti Foundation, Rome, Italy, Nuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, ‘Sapienza’ University, Rome, Italy, Department of Biochemical Sciences ‘A. Rossi Fanelli’, ‘Sapienza’ University, Rome, Italy, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Sensory Organs, ‘Sapienza’ University, Rome, Italy
  • Pages: 437-447
    |
    Published online on: June 1, 2016
       https://doi.org/10.3892/ijo.2016.3553
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Abstract

Clinical trials using antiangiogenic drugs revealed their potential against cancer. Unfortunately, a large percentage of patients does not yet benefit from this therapeutic approach highlighting the need of diagnostic tools to non-invasively evaluate and monitor response to therapy. It would also allow to predict which kind of patient will likely benefit of antiangiogenic therapy. Reasons for treatment failure might be due to a low expression of the drug targets or prevalence of other pathways. Molecular imaging has been therefore explored as a diagnostic technique of choice. Since the vascular endothelial growth factor (VEGF/VEGFR) pathway is the main responsible of tumor angiogenesis, several new drugs targeting either the soluble ligand or its receptor to inhibit signaling leading to tumor regression could be involved. Up today, it is difficult to determine VEGF or VEGFR local levels and their non-invasive measurement in tumors might give insight into the available target for VEGF/VEGFR-dependent antiangiogenic therapies, allowing therapy decision making and monitoring of response.
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Copy and paste a formatted citation
Spandidos Publications style
Taurone S, Galli F, Signore A, Agostinelli E, Dierckx RA, Minni A, Pucci M and Artico M: VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636. Int J Oncol 49: 437-447, 2016.
APA
Taurone, S., Galli, F., Signore, A., Agostinelli, E., Dierckx, R.A., Minni, A. ... Artico, M. (2016). VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636. International Journal of Oncology, 49, 437-447. https://doi.org/10.3892/ijo.2016.3553
MLA
Taurone, S., Galli, F., Signore, A., Agostinelli, E., Dierckx, R. A., Minni, A., Pucci, M., Artico, M."VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636". International Journal of Oncology 49.2 (2016): 437-447.
Chicago
Taurone, S., Galli, F., Signore, A., Agostinelli, E., Dierckx, R. A., Minni, A., Pucci, M., Artico, M."VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636". International Journal of Oncology 49, no. 2 (2016): 437-447. https://doi.org/10.3892/ijo.2016.3553
Copy and paste a formatted citation
x
Spandidos Publications style
Taurone S, Galli F, Signore A, Agostinelli E, Dierckx RA, Minni A, Pucci M and Artico M: VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636. Int J Oncol 49: 437-447, 2016.
APA
Taurone, S., Galli, F., Signore, A., Agostinelli, E., Dierckx, R.A., Minni, A. ... Artico, M. (2016). VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636. International Journal of Oncology, 49, 437-447. https://doi.org/10.3892/ijo.2016.3553
MLA
Taurone, S., Galli, F., Signore, A., Agostinelli, E., Dierckx, R. A., Minni, A., Pucci, M., Artico, M."VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636". International Journal of Oncology 49.2 (2016): 437-447.
Chicago
Taurone, S., Galli, F., Signore, A., Agostinelli, E., Dierckx, R. A., Minni, A., Pucci, M., Artico, M."VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review) Corrigendum in /10.3892/ijo.2016.3636". International Journal of Oncology 49, no. 2 (2016): 437-447. https://doi.org/10.3892/ijo.2016.3553
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