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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2011 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2011 Volume 4 Issue 4

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Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage

  • Authors:
    • Luxin Yu
    • Zongqian Nian
    • Jianli Sang

  • View Affiliations / Copyright

    Affiliations: Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, P.R. China, Protein Science Laboratory of Ministry of Education, School of Life Sciences, Tsinghua University, Beijing, P.R. China
  • Pages: 687-692
    |
    Published online on: April 26, 2011
       https://doi.org/10.3892/mmr.2011.480
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Abstract

Adipocytes are among the most important cells for energy storage, metabolism and balance in mammals. Dysfunctional adipocytes are closely associated with type 2 diabetes and obesity, and thus with insulin resistance and inflammation. Recent studies show that endoplasmic reticulum (ER) stress may be responsible for obesity-induced insulin resistance. In this study, we investigated an ER-associated degradation-related protein in adipocytes, namely osteosarcoma amplified 9 (OS-9), a protein that is reported to have lectin activity and to be involved in ER quality control. We found that OS-9 is expressed at high levels in both types of fat tissues – brown and white adipose tissues – and we examined the subcellular localization of OS-9 in 3T3-L1 adipocytes. Furthermore, we observed that the expression levels of the OS-9 protein gradually increased as 3T3-L1 adipocytes differentiated. Most notably, we found that the depletion of this protein influences adipocyte differentiation and lipid storage, although the mechanism behind this is unclear.

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Copy and paste a formatted citation
Spandidos Publications style
Yu L, Nian Z and Sang J: Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage. Mol Med Rep 4: 687-692, 2011.
APA
Yu, L., Nian, Z., & Sang, J. (2011). Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage. Molecular Medicine Reports, 4, 687-692. https://doi.org/10.3892/mmr.2011.480
MLA
Yu, L., Nian, Z., Sang, J."Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage". Molecular Medicine Reports 4.4 (2011): 687-692.
Chicago
Yu, L., Nian, Z., Sang, J."Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage". Molecular Medicine Reports 4, no. 4 (2011): 687-692. https://doi.org/10.3892/mmr.2011.480
Copy and paste a formatted citation
x
Spandidos Publications style
Yu L, Nian Z and Sang J: Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage. Mol Med Rep 4: 687-692, 2011.
APA
Yu, L., Nian, Z., & Sang, J. (2011). Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage. Molecular Medicine Reports, 4, 687-692. https://doi.org/10.3892/mmr.2011.480
MLA
Yu, L., Nian, Z., Sang, J."Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage". Molecular Medicine Reports 4.4 (2011): 687-692.
Chicago
Yu, L., Nian, Z., Sang, J."Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage". Molecular Medicine Reports 4, no. 4 (2011): 687-692. https://doi.org/10.3892/mmr.2011.480
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