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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2025 Volume 32 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Ginsenoside Rh1 inhibits tumor growth in mice with colorectal cancer and depressive symptoms via modulation of the gut microbiota and tumor microenvironment

Tingting Dai, Lingchang Li, Jiaxin Li, Xiaobin Tan, Yi Luo, Xuedong Wang, Jie Song, Sujuan Li, Songshan Shi
Article Number: 345
Published online on: 08 October 2025

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Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice  

Yu Ni, Xuheng Jiang, Shuhong Wang, Tao Pu, Tiantian Yan, Anyong Yu, Qi Liu
Article Number: 344
Published online on: 07 October 2025

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Glioma‑associated microglia and macrophages as a potential target for mTOR inhibition in glioblastoma

Pia S. Zeiner, Michael Schulz, Jana Schomber, Jan-Béla Weinem, Nadja I. Lorenz, Benedikt Sauer, Bastian Roller, Katharina J. Weber, Anna-Luisa Luger, Annemarie Berger, Karl H. Plate, Lisa Sevenich, Joachim P. Steinbach, Mohammed H. Mosa, Patrick N. Harter, Michael W. Ronellenfitsch
Article Number: 343
Published online on: 06 October 2025

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Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review)

Guofeng Xie, Yongping Xie, Xichao Xu
Article Number: 342
Published online on: 06 October 2025

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Astragalus polysaccharide as a potential antitumor immunomodulatory drug (Review)

Zi-Tong Qin, Zhi-Hang Wu, Can-Mo Wang, Xiu-Chen Xie, Ying-Hao Wang
Article Number: 341
Published online on: 06 October 2025

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Retraction Open Access

[Retracted] ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis

Rui Cheng, Xiaolong Liu, Zheng Wang, Kunlong Tang
Article Number: 340
Published online on: 06 October 2025

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Circular RNA hsa_circ_0000118 promotes atrial fibrosis by regulating the microRNA‑34a‑5p/Smad4 axis

Na Wu, Yuanbo Zhang, Yuhong Zeng, Lanqing Yang, Jun Li, Yanxiu Chen, Zhiquan Yuan, Xinghua Chen, Chengying Li, Long Wu, Tongjian Cai, Zhihui Zhang, Li Zhong, Yafei Li
Article Number: 339
Published online on: 02 October 2025

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Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves

Takamaru Suzuki, Kiyohito Naito, Daisuke Kubota, Yuji Ueno, Takako Negishi‑Koga, Yasuhiro Yamamoto, So Kawakita, Norizumi Imazu, Kenjiro Kawamura, Nobutaka Hattori, Muneaki Ishijima
Article Number: 338
Published online on: 01 October 2025

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Regulatory role of POSTN in keloid pathogenesis

Bin Jiang, Fan Zhuo, Xiahong Li, Kaoyuan Zhang, Jiaxu Gu, Jingwen Wu, Weilong Zhong, Yanfen Zou, Bo Yu, Cong Huang
Article Number: 337
Published online on: 01 October 2025

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Impact of lactylation on the pathogenesis of cancer and its clinical application potential (Review)

Xiaomei Wang, Jiaqing Chen, Bing Wang, Yanping Li, Xinyue Zhou, Yingqiu Song, Chenggui Miao, Yurong Huang
Article Number: 336
Published online on: 01 October 2025

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Thrombolytic therapy efficacy in cardiopulmonary resuscitation: Investigating the effect of recombinant tissue plasminogen activator (Review)

Wenbin Zhang, Yinpng Pan, Jian Ding, Dexin Xu, Wenhai Wang
Article Number: 335
Published online on: 01 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑363‑3p is downregulated in hepatocellular carcinoma and inhibits tumorigenesis by directly targeting specificity protein 1

Jie Ying, Xuechun Yu, Chaojian Ma, Yongqi Zhang, Jingwu Dong
Article Number: 334
Published online on: 29 September 2025

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Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review)

Zizhen Ye, Hanwei Zhao, Xuanhu Ye
Article Number: 333
Published online on: 26 September 2025

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From tumor immunotherapy to myocardial injury: A mechanistic discussion of immune checkpoint inhibitor‑related myocarditis (Review)

Leiyang Dai, Yong Duan, Qiuxia Xiong
Article Number: 332
Published online on: 26 September 2025

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HSPD1 regulates angiotensin II‑induced atrial fibrillation via the PPAR signaling pathway

Yimeng Zhou, Lianzhi Zhang, Shunping Zhou, Wenjia Zhang, Qunlin Gong, Nan Xu, Jiahong Wang, Zhong Zhang, Nannan Chen
Article Number: 331
Published online on: 26 September 2025

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Atractylodin inhibits ferroptosis in sepsis‑induced acute gastrointestinal injury via SIRT3/PRDX3

Yun-Xia Hu, Ming-Qi Chen, Jian-Lin Wang, Tao Wu, Hai-Dong Zhang, Tong-Tong Li, Hui Gao, Yu Bai
Article Number: 330
Published online on: 26 September 2025

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Cholesterol metabolism in LUAD progression: GJB3 as a key target for cell‑based therapeutic interventions

Qihang Yan, Wuguang Chang, Wingshing Wong, Li Gong, Dachuan Liang, Jie Yang, Junye Wang
Article Number: 329
Published online on: 26 September 2025

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Small dense LDL: An underestimated driver of atherosclerosis (Review)

Makhabbat Bekbossynova, Timur Saliev, Tatyana Ivanova‑Razumova, Saltanat Andossova, Aknur Kali, Gulzhan Myrzakhmetova
Article Number: 328
Published online on: 24 September 2025

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Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation

Jiajie Zhu, Liangjun Yang, Zheng Fang, Jiabin Chen, Yeqian Wu, Haiyan Liu, Shan Liu, Baoying Fei
Article Number: 327
Published online on: 23 September 2025

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Expression of Concern Open Access

[Expression of Concern] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 326
Published online on: 23 September 2025

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Research advancements regarding the relationship between FBXO2 and malignant tumors (Review)

Jieya Zhang, Jize Yang, Xiaomin Zhang, Yiran Yuan, Shuai Sun, Shihua Zhang, Jiefeng He
Article Number: 325
Published online on: 23 September 2025

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PARP‑1 in liver diseases: Molecular mechanisms, therapeutic potential and emerging clinical applications (Review)

Kaipeng Hu, Heng Tian, Shuxing Chen, Yuhan Liu, Ran Wei, Bangjie Chen, Yiwen Jia
Article Number: 324
Published online on: 22 September 2025

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[Expression of Concern] PirB restricts neuronal regeneration in developing rat brain following hypoxia‑ischemia

Hua Wang, Ying Xiong, Dezhi Mu
Article Number: 323
Published online on: 18 September 2025

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Article Open Access

Capsaicin attenuates sepsis‑associated encephalopathy by inhibiting neuroinflammation and apoptosis whilst activating mitophagy through the BNIP3/NIX pathway

Silun Zhang, Nanbo Luo, Hanxi Wu, Junfa Chen, Yonghan Jiang, Lifei Xiao, Hanlin Liang, Qingsheng Xue, Yan Luo, Buwei Yu, Yuqiang Liu, Zhiheng Liu
Article Number: 322
Published online on: 17 September 2025

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Article Open Access

Inhibitory effect of antibodies against the cell adhesion molecule gicerin on gastric cancer progression

Saaya Ueno, Nao Uemura, Kazuhide Adachi, Yasuhiro Tsukamoto
Article Number: 321
Published online on: 17 September 2025

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Correction Open Access

[Corrigendum] Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate‑induced osteoarthritis rats

Jin-Woo Jeong, Hye Hyeon Lee, Jongsik Kim, Eun-Ok Choi, Hyun Hwang-Bo, Hong Jae Kim, Min Young Kim, Kyu Im Ahn, Gi-Young Kim, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Su Hyun Hong, Cheol Park, Hee-Jae Cha, Yung Hyun Choi
Article Number: 320
Published online on: 16 September 2025

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Article

TGFβ1‑induced epithelial‑mesenchymal transition is associated with stathmin downregulation and increased microtubule stability in bronchial epithelial cells

Nur Amilia Hanie Mohamad Hasan, Yu Zhao Lee, Chau Ling Tham, Daud Ahmad Israf, Nuzul Noorahya Jambari, Hanis Hazeera Harith
Article Number: 319
Published online on: 15 September 2025

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Expression of Concern Open Access

[Expression of Concern] Inhibition of tumorigenesis and invasion of hepatocellular carcinoma by siRNA‑mediated silencing of the livin gene

Hui Liu, Shaochuang Wang, Hangyong Sun, Zeya Pan, Weiping Zhou, Mengchao Wu
Article Number: 318
Published online on: 12 September 2025

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Intestinal CD4+ T cells treated with Pseudostellaria heterophylla polysaccharide improve insulin resistance in BNL CL.2 cells by modulating PI3K/AKT signaling and energy metabolism

Yongjun Kan, Yingying Liu, Yating Huang, Li Zhao, Jiang Chang, Wensheng Pang, Wenxiong Lin, Juan Hu
Article Number: 317
Published online on: 11 September 2025

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Integrated metabolomics and transcriptomics analyses reveal changes in metabolites and their associated gene expression in the blood of patients with recurrent HSV‑2 genital herpes

Jianping He, Chenxi Feng, Yaohan Xu, Yan Chen, Siji Chen, Jiang Zhu, Yinjing Song, Hao Cheng
Article Number: 316
Published online on: 11 September 2025

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Heterogeneity and characteristic changes in cardiomyocytes and non‑cardiomyocytes following myocardial infarction: Insights from single‑cell sequencing analysis (Review)

Xinxin Bian, Haizhu Gao, Cuimei Guo, Nan Lin, Lijun Gan, Xueying Chen
Article Number: 315
Published online on: 10 September 2025

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Expression of Concern Open Access

[Expression of Concern] Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway

Hong-Yu Meng, De-Cheng Shao, Han Li, Xiao-Dan Huang, Guang Yang, Bing Xu, Hai-Yun Niu
Article Number: 314
Published online on: 10 September 2025

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Role of the gut‑lung axis in bronchopulmonary dysplasia: Physiological basis, pathogenesis and immunological modulation (Review)

Yue Zhu, Rui-Dong Ding
Article Number: 313
Published online on: 09 September 2025

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Correction Open Access

[Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells

Jinlin Hou, Anguo Cui, Peiying Song, Hui Hua, Ting Luo, Yangfu Jiang
Article Number: 312
Published online on: 08 September 2025

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Article Open Access

Induction of CXCL8 by endoplasmic reticulum stress promotes migration and invasion of esophageal squamous cell carcinoma through activation of SMAD2/3

Junhong Wu, Fangyu Su, Juntao Lu, Huanchen Xu, Xia Yang, Fei Li, Lei Liu, Wei Guo
Article Number: 311
Published online on: 05 September 2025

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Journal Cover
January-2026 Volume 33 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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Article Open Access

MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Review Open Access

Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Article Open Access

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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Review Open Access

The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Article Open Access

Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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Correction Open Access

[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Review Open Access

Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Review

RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Article Open Access

Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

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Retraction Open Access

[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
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Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Review

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Review

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D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways

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