Molecular Medicine Reports Special Issues

Molecular mechanism in occupational and environmental medicine

Lead Editor:

    Professor Caterina Ledda
    University of Catania
    Italy

Environmental and occupational health is influenced by chemical, physical, radiological, and biological agents in the air, water, and soil. Health risks involve injury, and exposure to radiation, carcinogenic and teratogenic agents, leading to cancer, lung and heart diseases. Environmental and occupational factors may cause in sudden death or long-term illness from hazardous environmental or working conditions. The environment impacts people from workplace settings to large-scale communities and getting global effects. The objective of the present Special Issue will be to give new scientific evidence on molecular mechanism in occupational and environmental medicine.


Submission deadline: 17 February 2023

Microenvironment and cell state, plasticity, and drug response in Hepatic and Biliary Cancer

Lead Editor:

    Professor Consolato Sergi
    Chief, Anatomic Pathology Division, Pediatric Pathologist, Children’s Hospital of Eastern Ontario (CHEO) Full Professor of Pathology & Pediatrics, Univ. Alberta & Ottawa
    Canada

Precision medicine is changing the approach to patients harboring neoplasms. The diversity of cancer in the gastrointestinal and hepatobiliary systems has evidenced that it can complicate the estimation of prognosis. The optimal timing and selection of treatment regimens for individual patients may be jeopardized. In colon-rectal cancer, pathological staging by tumor-node-metastasis (TNM), sidedness, and a few molecular markers, including mismatch repair (MMR), BRAF (B-Raf proto-oncogene serine/threonine kinase), and RAS (Kirsten rat sarcoma) mutation status, are usually used in clinical practice to identify patients for specific therapies. Recently, the BEACON drug regimen (encorafenib as BRAF-inhibitor, binimetinib as MAP2K-inhibitor or Mitogen-activated protein kinase kinase (also MEK), and cetuximab as anti-EGFR, anti-epithelial growth factor receptor) has been proposed to be effective for BRAF mutant metastatic colo-rectal cancer. The consensus molecular subtype (CMS) classification is a stratification strategy for colo-rectal cancer established because of differences in tumor biology rather than clinical outcomes. It captures the intrinsic biomolecular heterogeneity of colon-rectal cancer. It is based on differential gene expression in tumor tissue, encompassing both cancer cells as well as the microenvironment. Colon-rectal cancer can be divided into 4 subtypes (CMS1-4). CMS1 is the immunogenic subtype, enriched for MSI tumors and BRAF mutations. Epithelial characteristics with marked WNT (Wnt/β-Catenin signaling pathway) and MYC (Myelocytomatosis) signaling and high chromosomal instability (CIN) characterize CMS2. The CMS3 has epithelial features but less CIN. It is enriched for KRAS mutations, and occurs with evident metabolic dysregulation. Finally, the CMS4 is the mesenchymal subtype with prominent transforming growth factor beta (TGF-β) activation, stromal invasion, angiogenesis, and an inflammatory, immunosuppressive phenotype. Hepatocellular carcinoma can also be stratified into four distinct immune subtypes. Hepatocellular carcinoma with a high immune activation is characterized by high anti-tumor immunity accompanied with high cancer-related hallmark signatures. They include epithelial–mesenchymal transition, angiogenesis, and apoptosis. Autophagy-related proteins (Beclin-1, LAMP-1, LC3, and p62) and NanoString technology for gene expression have been used to pinpoint the microenvironment for the EBV-driven oncogenesis. The microenvironment of tumors is dynamic, with a variety of cell types and different molecular pathways at play, and studies may clearly warrant further investigation. In this special issue, we welcome papers addressing the tumor microenvironment and cell state, plasticity, and drug response in hepatic and biliary oncogenesis.


Submission deadline: 31 January 2023

Biological properties and potential biomedical applications of plant extracts, essential oils and secondary metabolites from natural products.

Lead Editor:

    Dr Antonella D'Anneo
    University of Palermo. Dep of Biological, Chemical and Pharmaceutical Sciences and Technologies
    Italy

In the last years a re-evaluation of essential oils, natural extracts as well as secondary metabolites derived from plants or their parts have attracted researchers attentions operating in the field of phyto-therapeutic medicine for their multifaceted abilities spacing from anti-oxidant, anti-inflammatory, anti-tumor, antimicrobial and anti-viral actions. Many investigations have been made with the aim to identify new potential lead compounds to apply, alone or in combination, as preventive or supportive therapy for the treatment of some human pathologies. Several studies have provided evidence that many essential oils or natural extracts derived from medicinal plants offer a plethora of effective antioxidants with potential in the prevention or in the treatment of inflammatory, degenerative or tumor diseases. Among the main antioxidant components present in plant or their parts (root, bark, flowers, leaves ect.), polyphenols represents a class of naturally-occurring phytochemicals, some of which are able to modulate many distinct physiological and molecular pathways involved in different pathological conditions. We invite investigators to contribute to this Special issue with an original paper on their recent findings or a review putting together experimental data and critical points of view on the biological properties and biomedical applications of phytochemicals, essentials oil or plant derived extracts.


Submission deadline: 21 January 2023

Liquid biopsy for cancer management

Lead Editor:

    Dr Tomasz Powrózek
    Department of Human Physiology, Medical University in Lublin
    Poland

One of the major advantage for analysis of circulating nucleic acids as cancer biomarkers is their remarkable stability in body fluids and significantly altered expression under the cancer conditions. They are both released to blood circulation from cancerous tissues (directly or within the exosomes) or from host tissues affected by tumor occurrence. Monitoring of circulating biomarkers, especially in blood circulation (plasma or serum) is more convenient and safer for patient than series of tissue biopsy. Liquid biosy allows to capture the entire heterogeneity of the tumor (primary/metastatic/recurrent) with minimally invasive manner. Liquid biopsy offers clinical applicability for cancer detection, prediction and prognosis. The aim of the special issue is summarizing the utility of circulating biomarkers (expression of ncRNAs, DNA methylation) with the use of liquid biopsy for cancer management.


Submission deadline: 07 January 2023

Journal Cover

July-2022
Volume 26 Issue 1

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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