Molecular Medicine Reports Special Issues

Liquid biopsy for cancer management

Lead Editor:

    Dr Tomasz Powrózek
    Department of Human Physiology, Medical University in Lublin

One of the major advantage for analysis of circulating nucleic acids as cancer biomarkers is their remarkable stability in body fluids and significantly altered expression under the cancer conditions. They are both released to blood circulation from cancerous tissues (directly or within the exosomes) or from host tissues affected by tumor occurrence. Monitoring of circulating biomarkers, especially in blood circulation (plasma or serum) is more convenient and safer for patient than series of tissue biopsy. Liquid biosy allows to capture the entire heterogeneity of the tumor (primary/metastatic/recurrent) with minimally invasive manner. Liquid biopsy offers clinical applicability for cancer detection, prediction and prognosis. The aim of the special issue is summarizing the utility of circulating biomarkers (expression of ncRNAs, DNA methylation) with the use of liquid biopsy for cancer management.

Submission deadline: 07 July 2022

The regulation and function of gene transcription and protein post-translational modification on tumorigenesis, progression and drug

Lead Editor:

    Dr Dejie Wang
    mayo clinic
    United States

Abnormal gene transcription often leads to human diseases, such as cancer. Moreover, dysregulation of the functions of transcription regulatory proteins by mechanisms such as phosphorylation, acetylation, ubiquitination, methylation, and protein-protein initiates and develops many types of cancers. Deep understanding of these processes will not only shed new light on the etiology of cancer but also may lead to identifying novel targets for diagnostics, prognostics and therapeutics for those lethal diseases.

Submission deadline: 30 June 2022

Clinical utility of liquid biopsies as diagnostic or prognostic tools for cancer

Lead Editor:

    Dr Emmanouil Karteris
    Brunel University
    United Kingdom

Liquid biopsies offer a promising alternative to tissue samples, providing non-invasive diagnostic approaches or serial monitoring of disease evolution. However, certain challenges remain, and the full potential of liquid biopsies has yet to be reached. In this Special Issue, we will invite clinical and basic scientists to showcase their latest research in this field.

Submission deadline: 23 June 2022

Pharmacologic Chaperone

Lead Editor:

    Professor Seong-Gon Kim
    Gangneung-Wonju National University
    Republic of Korea

Chaperone is used for alleviating stress from the environment. Chaperone can improve the survival rate of organism. Using chaperone, there have been many trials to treat the challenging diseases. This special issue aims to collect the articles about molecular mechanism of pharmacologic chaperone, target disease for pharmacologic chaperone, and clinical application of pharmacologic chaperone.

Submission deadline: 22 June 2022

Direct oral anticoagulants for cancer-associated venous thromboembolism in Japan

Lead Editor:

    Dr Yoshinori Imamura
    Kobe University Hospital

Cancer-associated venous thromboembolism is a severe and potentially fatal event. Over the past few years, results from several randomized control trials have been published, and direct oral anticoagulants are becoming new standard care for this disease in addition to low molecular weight heparins. Although Japanese patients have seldom participated in these trials, direct oral anticoagulants are widely used in current practice, especially because low molecular weight heparins have not been approved for acute venous thromboembolism in Japan. Since the “East Asian paradox” meant a unique risk-benefit compromise, less anti-ischemic benefits and more risk of bleeding during antithrombotic therapies compared with Caucasian patients, direct extrapolation of Caucasian data to Japanese could be inappropriate. Polymorphisms among anticoagulant factors, cytochrome P450 metabolisms, and ATP-binding cassette transporters may be important biological factors to explain the ethnic disparity. This special issue will focus on the current evidence and future directions of direct oral anticoagulants for cancer-associated venous thromboembolism in Japanese patients.

Submission deadline: 22 June 2022

Journal Cover

Volume 25 Issue 2

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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