Antitumor activity of bee pollen polysaccharides from Rosa rugosa

  • Authors:
    • Bo Wang
    • Qiyu Diao
    • Zhongyu Zhang
    • Yang Liu
    • Qipin Gao
    • Yifa Zhou
    • Shanshan Li
  • View Affiliations

  • Published online on: March 20, 2013     https://doi.org/10.3892/mmr.2013.1382
  • Pages: 1555-1558
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Abstract

In the present study, bee pollen polysaccharides from Rosa rugosa (WRPP) were extracted and fractionated. WRPP were purified to neutral (WRPP-N) and acidic polysaccharides (WRPP-1, WRPP-2) with DEAE-Cellulose. WRPP-N were mainly composed of glucose, mannose, arabinose and galactose, indicating the existence of glucan, arabinogalactan (AG) and mannoglucan. WRPP-1 mainly consisted of rhamnose (3.0%), galacturonic acid (12.4%), galactose (24.7%) and arabinose (53.9%), and contained a large proportion of AGs. WRPP-2 consisted of rhamnose (7.8%), galacturonic acid (23.0%), galactose (15%) and arabinose (48.7%), while WRPP-2 contained more galacturonic acid compared to WRPP-1. WRPP-1 and WRPP-2 were composed by type I rhamnogalacturonan (RG-I), homogalacturonan (HG) and AG fragments, while WRPP-2 contained more HG and RG-I. All the fractions had significant anti-proliferative activity in HT-29 and HCT116 cells; the neutral and acidic fractions were shown to have significant synergistic effects which accounted for the antitumor activity of bee pollen polysaccharides from Rosa rugosa in vitro.
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May 2013
Volume 7 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang B, Diao Q, Zhang Z, Liu Y, Gao Q, Zhou Y and Li S: Antitumor activity of bee pollen polysaccharides from Rosa rugosa. Mol Med Rep 7: 1555-1558, 2013.
APA
Wang, B., Diao, Q., Zhang, Z., Liu, Y., Gao, Q., Zhou, Y., & Li, S. (2013). Antitumor activity of bee pollen polysaccharides from Rosa rugosa. Molecular Medicine Reports, 7, 1555-1558. https://doi.org/10.3892/mmr.2013.1382
MLA
Wang, B., Diao, Q., Zhang, Z., Liu, Y., Gao, Q., Zhou, Y., Li, S."Antitumor activity of bee pollen polysaccharides from Rosa rugosa". Molecular Medicine Reports 7.5 (2013): 1555-1558.
Chicago
Wang, B., Diao, Q., Zhang, Z., Liu, Y., Gao, Q., Zhou, Y., Li, S."Antitumor activity of bee pollen polysaccharides from Rosa rugosa". Molecular Medicine Reports 7, no. 5 (2013): 1555-1558. https://doi.org/10.3892/mmr.2013.1382