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2014-February Volume 9 Issue 2

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Article

Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor

  • Authors:
    • Jing Dong
    • Mingjun Cheng
    • Hong Sun
  • View Affiliations / Copyright

    Affiliations: Obstetrics and Gynecology Hospital, Shanghai Medical College, Fudan University, Shanghai 200011, P.R. China
  • Pages: 583-589
    |
    Published online on: December 2, 2013
       https://doi.org/10.3892/mmr.2013.1838
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Abstract

Inducible nitric oxide synthase (iNOS) is the key enzyme in NO synthesis and exhibits a high expression in numerous types of malignant tumors. Previous studies have demonstrated that iNOS promotes the production of tumor blood vessels by catalyzing the synthesis of additional NO. Certain experimental evidence has suggested that iNOS may regulate the levels of vascular endothelial growth factor (VEGF), as the level of VEGF may be induced by iNOS during endothelial cell migration and angiogenesis. In this study, it was observed that SiHa and HeLa cells exhibit depressed proliferation levels following the knockdown of iNOS with a lentivirus. In addition, NO levels demonstrated a correlation with VEGF levels in the cell culture supernatant.
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Copy and paste a formatted citation
Spandidos Publications style
Dong J, Cheng M and Sun H: Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor. Mol Med Rep 9: 583-589, 2014.
APA
Dong, J., Cheng, M., & Sun, H. (2014). Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor. Molecular Medicine Reports, 9, 583-589. https://doi.org/10.3892/mmr.2013.1838
MLA
Dong, J., Cheng, M., Sun, H."Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor". Molecular Medicine Reports 9.2 (2014): 583-589.
Chicago
Dong, J., Cheng, M., Sun, H."Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor". Molecular Medicine Reports 9, no. 2 (2014): 583-589. https://doi.org/10.3892/mmr.2013.1838
Copy and paste a formatted citation
x
Spandidos Publications style
Dong J, Cheng M and Sun H: Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor. Mol Med Rep 9: 583-589, 2014.
APA
Dong, J., Cheng, M., & Sun, H. (2014). Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor. Molecular Medicine Reports, 9, 583-589. https://doi.org/10.3892/mmr.2013.1838
MLA
Dong, J., Cheng, M., Sun, H."Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor". Molecular Medicine Reports 9.2 (2014): 583-589.
Chicago
Dong, J., Cheng, M., Sun, H."Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor". Molecular Medicine Reports 9, no. 2 (2014): 583-589. https://doi.org/10.3892/mmr.2013.1838
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