Open Access

Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord

Corrigendum in: /10.3892/mmr.2022.12919 Corrigendum in: /10.3892/mmr.2022.12920

  • Authors:
    • Jing Li
    • Shi‑Qing Xu
    • Yu‑Ming Zhao
    • Shi Yu
    • Li‑Hong Ge
    • Bao‑Hua Xu
  • View Affiliations

  • Published online on: September 20, 2018     https://doi.org/10.3892/mmr.2018.9501
  • Pages: 4969-4977
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological characteristics including surface markers, proliferation capacity, tumorigenicity and immunogenicity were analyzed by flow cytometric analysis, ELISA and co‑culture with human lymphocytes, respectively. The results indicated that all four types of stem cells obtained from different sources expressed MSC surface markers, and they did not show tumorigenicity either in vivo or in vitro. Stem cells from SHED exhibited the strongest proliferation capacity. Umbilical cord‑derived MSCs displayed the strongest immunomodulatory ability, while bone marrow MSCs exhibited the best antigen‑presenting potential in response to interferon‑γ stimulation. These results provide information on MSCs derived from different tissues, which may be helpful in their clinical application.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li J, Xu SQ, Zhao YM, Yu S, Ge LH and Xu BH: Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord Corrigendum in /10.3892/mmr.2022.12919 Corrigendum in /10.3892/mmr.2022.12920. Mol Med Rep 18: 4969-4977, 2018
APA
Li, J., Xu, S., Zhao, Y., Yu, S., Ge, L., & Xu, B. (2018). Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord Corrigendum in /10.3892/mmr.2022.12919 Corrigendum in /10.3892/mmr.2022.12920. Molecular Medicine Reports, 18, 4969-4977. https://doi.org/10.3892/mmr.2018.9501
MLA
Li, J., Xu, S., Zhao, Y., Yu, S., Ge, L., Xu, B."Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord Corrigendum in /10.3892/mmr.2022.12919 Corrigendum in /10.3892/mmr.2022.12920". Molecular Medicine Reports 18.6 (2018): 4969-4977.
Chicago
Li, J., Xu, S., Zhao, Y., Yu, S., Ge, L., Xu, B."Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord Corrigendum in /10.3892/mmr.2022.12919 Corrigendum in /10.3892/mmr.2022.12920". Molecular Medicine Reports 18, no. 6 (2018): 4969-4977. https://doi.org/10.3892/mmr.2018.9501