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Article

Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles

  • Authors:
    • Zhenyu Liang
    • Fei Long
    • Fengyan Wang
    • Yuqiong Yang
    • Jing Xiao
    • Kuimiao Deng
    • Weili Gu
    • Luqian Zhou
    • Jiaxing Xie
    • Wenhua Jian
    • Xin Chen
    • Mei Jiang
    • Jinping Zheng
    • Tao Peng
    • Rongchang Chen
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China, State Key Laboratory of Respiratory Disease, Sino‑French Hoffmann Institute, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China, Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
  • Pages: 2882-2892
    |
    Published online on: July 12, 2019
       https://doi.org/10.3892/mmr.2019.10498
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Abstract

Autoimmunity may serve a role in the pathological features of a subgroup of patients with chronic obstructive pulmonary disease (COPD); however, in immunological subgroups of COPD patients, the interrelationships between airway and circulating autoantibody responses, and clinical parameters, remain unclear. The present study was undertaken to evaluate these interrelationships in various immunological subgroups of COPD patients. Sputum supernatant and serum obtained from 102 patients with stable COPD were assayed for the presence of immunoglobulin G antibodies against ten autoantigens via Luminex multiplex technology. Hierarchical clustering based on principal components was performed on autoantibody profiles to classify patients into clusters. Network‑based and module analyses were conducted to explore interrelationships among autoantibodies and clinical variables in each cluster. Topological characteristics were compared between clusters. Unsupervised clustering identified four clusters: No significant differences in the majority of clinical characteristics were observed among clusters. In cluster 1, retrospective exacerbation was only positively associated with COPD assessment test score. Lung functions (predicted % of forced expiratory volume in 1 sec and maximal mid‑expiratory flow) were negatively associated with exacerbation risk only in cluster 2. Sputum autoantibodies (against U1 small nuclear ribonucleoprotein, proteinase‑3 and Ro/Sjögren syndrome type A antigen) were negatively associated with exacerbation risks in cluster 2, but positively associated in cluster 3. The four networks also exhibited distinct topological properties. In COPD, autoantibody responses were heterogeneous and differentially associated with exacerbation risk in certain subgroups; their dual character should be considered in future research.
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Copy and paste a formatted citation
Spandidos Publications style
Liang Z, Long F, Wang F, Yang Y, Xiao J, Deng K, Gu W, Zhou L, Xie J, Jian W, Jian W, et al: Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles. Mol Med Rep 20: 2882-2892, 2019.
APA
Liang, Z., Long, F., Wang, F., Yang, Y., Xiao, J., Deng, K. ... Chen, R. (2019). Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles. Molecular Medicine Reports, 20, 2882-2892. https://doi.org/10.3892/mmr.2019.10498
MLA
Liang, Z., Long, F., Wang, F., Yang, Y., Xiao, J., Deng, K., Gu, W., Zhou, L., Xie, J., Jian, W., Chen, X., Jiang, M., Zheng, J., Peng, T., Chen, R."Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles". Molecular Medicine Reports 20.3 (2019): 2882-2892.
Chicago
Liang, Z., Long, F., Wang, F., Yang, Y., Xiao, J., Deng, K., Gu, W., Zhou, L., Xie, J., Jian, W., Chen, X., Jiang, M., Zheng, J., Peng, T., Chen, R."Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles". Molecular Medicine Reports 20, no. 3 (2019): 2882-2892. https://doi.org/10.3892/mmr.2019.10498
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Z, Long F, Wang F, Yang Y, Xiao J, Deng K, Gu W, Zhou L, Xie J, Jian W, Jian W, et al: Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles. Mol Med Rep 20: 2882-2892, 2019.
APA
Liang, Z., Long, F., Wang, F., Yang, Y., Xiao, J., Deng, K. ... Chen, R. (2019). Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles. Molecular Medicine Reports, 20, 2882-2892. https://doi.org/10.3892/mmr.2019.10498
MLA
Liang, Z., Long, F., Wang, F., Yang, Y., Xiao, J., Deng, K., Gu, W., Zhou, L., Xie, J., Jian, W., Chen, X., Jiang, M., Zheng, J., Peng, T., Chen, R."Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles". Molecular Medicine Reports 20.3 (2019): 2882-2892.
Chicago
Liang, Z., Long, F., Wang, F., Yang, Y., Xiao, J., Deng, K., Gu, W., Zhou, L., Xie, J., Jian, W., Chen, X., Jiang, M., Zheng, J., Peng, T., Chen, R."Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles". Molecular Medicine Reports 20, no. 3 (2019): 2882-2892. https://doi.org/10.3892/mmr.2019.10498
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