Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review)

  • Authors:
    • Xinqiang Song
    • Yu Zhang
    • Erqin Dai
  • View Affiliations

  • Published online on: April 2, 2020     https://doi.org/10.3892/mmr.2020.11052
  • Pages: 2303-2310
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Abstract

Celastrol and triptolide, chemical compounds isolated from Tripterygium wilfordii hook (also known as thunder god vine), are effective against rheumatoid arthritis (RA). Celastrol targets numerous signaling pathways involving NF‑κB, endoplasmic reticulum Ca2+‑ATPase, myeloid differentiation factor 2, toll‑like receptor 4, pro‑inflammatory chemokines, DNA damage, cell cycle arrest and apoptosis. Triptolide, inhibits NF‑κB, the receptor activator of NF‑κB (RANK)/RANK ligand/osteoprotegerin signaling pathway, cyclooxygenase‑2, matrix metalloproteases and cytokines. The present review examined the chemistry and bioavailability of celastrol and triptolide, and their molecular targets in treating RA. Clinical studies have demonstrated that T. wilfordii has several promising bioactivities, but its multi‑target toxicity has restricted its application. Thus, dosage control and structural modification of T. wilfordii are required to reduce the toxicity. In this review, future directions for research into these promising natural products are discussed.
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June-2020
Volume 21 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Song X, Zhang Y and Dai E: Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review). Mol Med Rep 21: 2303-2310, 2020.
APA
Song, X., Zhang, Y., & Dai, E. (2020). Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review). Molecular Medicine Reports, 21, 2303-2310. https://doi.org/10.3892/mmr.2020.11052
MLA
Song, X., Zhang, Y., Dai, E."Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review)". Molecular Medicine Reports 21.6 (2020): 2303-2310.
Chicago
Song, X., Zhang, Y., Dai, E."Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review)". Molecular Medicine Reports 21, no. 6 (2020): 2303-2310. https://doi.org/10.3892/mmr.2020.11052