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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2020 Volume 21 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Editorial Open Access

[Editorial] Possibility of transmission through dogs being a contributing factor to the extreme Covid‑19 outbreak in North Italy

Marina Goumenou, Demetrios A. Spandidos, Aristidis Tsatsakis
Pages: 2293-2295
Published online on: 23 March 2020

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Article Open Access

Novel compound heterozygous variant of BSCL2 identified by whole exome sequencing and multiplex ligation‑dependent probe amplification in an infant with congenital generalized lipodystrophy

Bobo Xie, Xin Fan, Yaqin Lei, Shang Yi, Qi Yang, Jin Wang, Zailong Qin, Fei Shen, Jingsi Luo, Yiping Shen
Pages: 2296-2302
Published online on: 23 March 2020

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Review

Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review)

Xinqiang Song, Yu Zhang, Erqin Dai
Pages: 2303-2310
Published online on: 02 April 2020

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Review Open Access

Neuregulin‑1: An underlying protective force of cardiac dysfunction in sepsis (Review)

Wen Kang, Yue Cheng, Xi Wang, Fang Zhou, Chenliang Zhou, Long Wang, Liang Zhong
Pages: 2311-2320
Published online on: 20 March 2020

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Article Open Access

Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

Hong Zhao, Chundi Li, Lina Li, Junying Liu, Yinghui Gao, Kun Mu, Donghe Chen, Aiping Lu, Yuanyuan Ren, Zhenhua Li
Pages: 2321-2334
Published online on: 01 April 2020

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Article Open Access

Abnormal DNA methylation patterns in patients with infection‑caused leukocytopenia based on methylation microarrays

Chao Wu, Xirennayi Muhataer, Wenyi Wang, Mingqin Deng, Rong Jin, Zhichuang Lian, Dan Luo, Yafang Li, Xiaohong Yang
Pages: 2335-2348
Published online on: 08 April 2020

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Article

Calycosin induces apoptosis in osteosarcoma cell line via ERβ‑mediated PI3K/Akt signaling pathways

Wei Tian, Zhi‑Wei Wang, Bao‑Ming Yuan, Yong‑Ge Bao
Pages: 2349-2356
Published online on: 26 March 2020

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Article Open Access

Effect of CD44 on differentiation of human amniotic mesenchymal stem cells into chondrocytes via Smad and ERK signaling pathways

Yan Xu, Yi‑Qing Wang, Ai‑Tong Wang, Chang‑Yin Yu, Yi Luo, Ru‑Ming Liu, Yu‑Jie Zhao, Jian‑Hui Xiao
Pages: 2357-2366
Published online on: 30 March 2020

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Article Open Access

A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule‑severing function

Jiong Li, Fengming Wu, Longfei Cheng, Jiaqi Zhang, Caihui Cha, Li Chen, Taoshan Feng, Jifeng Zhang, Guoqing Guo
Pages: 2367-2374
Published online on: 26 March 2020

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Article Open Access

A novel plasma lncRNA ENST00000416361 is upregulated in coronary artery disease and is related to inflammation and lipid metabolism

Ping Li, Xinxin Yan, Guidong Xu, Zhi Pang, Jiayi Weng, Juan Yin, Meifen Li, Lan Yu, Qian Chen, Kangyun Sun
Pages: 2375-2384
Published online on: 08 April 2020

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Article Open Access

Effects of electrical stimulation on cell activity, cell cycle, cell apoptosis and β‑catenin pathway in the injured dorsal root ganglion cell

Ming Hu, Li Hong, Songming He, Guotao Huang, Yanxiang Cheng, Qian Chen
Pages: 2385-2394
Published online on: 08 April 2020

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Article Open Access

Circular RNA Circ100084 functions as sponge of miR‑23a‑5p to regulate IGF2 expression in hepatocellular carcinoma

Jie Yang, Ying Li, Zuochun Yu, Yuefen Zhou, Jianfei Tu, Jian Lou, Yonghui Wang
Pages: 2395-2404
Published online on: 10 April 2020

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Article Open Access

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration

Faxiang Wang, Jie Zhu, Jian Zheng, Wei Duan, Zhujuan Zhou
Pages: 2405-2414
Published online on: 08 April 2020

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Article Open Access

Screening of differentially expressed miRNAs in tensile strain‑treated HepG2 cells by miRNA microarray analysis

Xu Luo, Si Shen, Suhong Yi, Jiangfeng Hu, Yunchen Sun, Kewei Gao, Liang Zhu
Pages: 2415-2426
Published online on: 07 April 2020

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Article Open Access

Relationship between autophagy, apoptosis and endoplasmic reticulum stress induced by melatonin in osteoblasts by septin7 expression

Cui Cui, Tao Lin, Zunlei Gong, Yue Zhu
Pages: 2427-2434
Published online on: 08 April 2020

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Article Open Access

MEG3 regulates apoptosis of adipose‑derived stem cells

Yao Shi
Pages: 2435-2442
Published online on: 08 April 2020

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Article Open Access

Ketamine promotes the neural differentiation of mouse embryonic stem cells by activating mTOR

Xuhui Zhou, Xiang Lv, Lei Zhang, Jia Yan, Rong Hu, Yu Sun, Siwei Xi, Hong Jiang
Pages: 2443-2451
Published online on: 30 March 2020

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Article Open Access

Changes in miRNA expressions in the injured small intestine of mice following high‑dose radiation exposure

Mitsuru Chiba, Haruka Uehara, Ikumi Niiyama, Haruka Kuwata, Satoru Monzen
Pages: 2452-2458
Published online on: 02 April 2020

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Case Report Open Access

Whole exome sequencing identified a pathogenic nonsense mutation in LMNA in a family with a progressive cardiac conduction defect: A case report

Peng Fan, Di Zhang, Kun‑Qi Yang, Tao Tian, Fang Luo, Ya‑Xin Liu, Lin‑Ping Wang, Xian‑Liang Zhou
Pages: 2459-2465
Published online on: 01 April 2020

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Article Open Access

Total saponin of Dioscorea collettii attenuates MSU crystal‑induced inflammation via inhibiting the activation of the NALP3 inflammasome and caspase‑1 in THP‑1 macrophages

Lu Wang, Liran Zhu, Chenfangyuan Duan, Lu Li, Guangliang Chen
Pages: 2466-2474
Published online on: 20 March 2020

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Article Open Access

Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice

Zhongkun Ren, Zhiyong Yang, Yi Lu, Rongping Zhang, Hui Yang
Pages: 2475-2483
Published online on: 26 March 2020

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Article Open Access

HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions

Zhan Zhang, Chenxi Huang, Ping Wang, Junjun Gao, Xin Liu, Yingying Li, Shujun Yan, Ying Shi
Pages: 2484-2492
Published online on: 01 April 2020

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Article Open Access

miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth

Jianjun Wang, Yunchun Li, Qianfeng Ma, Jiaxin Huang
Pages: 2493-2501
Published online on: 30 March 2020

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Article Open Access

Overexpression of antisense long non‑coding RNA ZNF710‑AS1‑202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression

Gang Li, Menghan Xie, Zhenlin Huang, Hao Li, Peng Li, Zhengguo Zhang, Yinghui Ding, Zhankui Jia, Jinjian Yang
Pages: 2502-2512
Published online on: 20 March 2020

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Article Open Access

Inflammatory response is modulated by lincRNACox2 via the NF‑κB pathway in macrophages infected by Mycobacterium tuberculosis

Danye Li, Caiyan Gao, Ling Zhao, Yongming Zhang
Pages: 2513-2521
Published online on: 02 April 2020

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Article Open Access

CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway

Rong Wang, Keliang Huang
Pages: 2522-2532
Published online on: 01 April 2020

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Article Open Access

Application of weighted gene co‑expression network analysis to explore the potential diagnostic biomarkers for colorectal cancer

Liping Qin, Jianping Zeng, Nannan Shi, Liu Chen, Li Wang
Pages: 2533-2543
Published online on: 01 April 2020

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Article Open Access

Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail‑induced epithelial‑mesenchymal transition

Qiongyao Zeng, Yu Zhang, Wenjing Zhang, Qiang Guo
Pages: 2544-2552
Published online on: 01 April 2020

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Article Open Access

Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells

Bo Hu, Xike Zhu, Jibin Lu
Pages: 2553-2559
Published online on: 10 April 2020

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Article Open Access

Long non‑coding RNA NORAD regulates angiogenesis of human umbilical vein endothelial cells via miR‑590‑3p under hypoxic conditions

Xiaoxue Zhao, Xiufang Wei, Xueying Wang, Guoxian Qi
Pages: 2560-2570
Published online on: 08 April 2020

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Article Open Access

SKLB1002, a potent inhibitor of VEGF receptor 2 signaling, inhibits endothelial angiogenic function in vitro and ocular angiogenesis in vivo

Qiu‑Yang Zhang, Shu‑Ya Tao, Chang Lu, Jing‑Jing Li, Xiu‑Miao Li, Jin Yao, Qin Jiang, Biao Yan
Pages: 2571-2579
Published online on: 06 April 2020

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Article Open Access

Low shear stress induces endothelial cell apoptosis and monocyte adhesion by upregulating PECAM‑1 expression

Xiangrong Xie, Feng Wang, Linlin Zhu, Hongfeng Yang, Daorong Pan, Yan Liu, Xinliang Qu, Yue Gu, Xiaobo Li, Shaoliang Chen
Pages: 2580-2588
Published online on: 08 April 2020

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Article

MicroRNA‑28 promotes the proliferation of non‑small‑cell lung cancer cells by targeting PTEN

Fenghe Cui, Qian Zhou, Kuang Xiao, Haiyun Qian
Pages: 2589-2596
Published online on: 20 March 2020

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Article

Whole‑exome sequencing study identifies two novel rare variations associated with congenital talipes equinovarus

Jing Zhang, Shang Li, Suling Ma, Yan Liu, Xuan Wang, Yazhou Li
Pages: 2597-2602
Published online on: 26 March 2020

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Article

Berberine induces lipolysis in porcine adipocytes by activating the AMP‑activated protein kinase pathway

Yongqing Yang, Rongsheng Lu, Fangfang Gao, Jie Zhang, Fenglan Liu
Pages: 2603-2614
Published online on: 10 April 2020

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Article

Effects and mechanism of the etanercept on pancreatic encephalopathy

Yifan Lv, Guojie Jing, Gang Zhu, Honghai Luo, Baisheng Li, Yituan Xie, Caiming Li, Xiangyu Wang
Pages: 2615-2623
Published online on: 08 April 2020

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Article

4,4'‑Bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma

Li Chen, Miao‑Miao Cheng, Ya‑Ping Li, Shao‑Feng Lin, Qiu‑Hong Zheng, Qin‑Ying Liu
Pages: 2624-2632
Published online on: 06 April 2020

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Article

Wnt2 overexpression protects against PINK1 mutant‑induced mitochondrial dysfunction and oxidative stress

Sui‑Rui Xia, Xue‑Yi Wen, Xiao‑Li Fan, Xiao‑Rong Chen, Zai‑Wa Wei, Qing‑Hua Li, Li Sun
Pages: 2633-2641
Published online on: 08 April 2020

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Correction Open Access

[Corrigendum] Promotion of microglial phagocytosis by tuftsin stimulates remyelination in experimental autoimmune encephalomyelitis

Zheng Bao, Jinqi Hao, Yuhong Li, Fumin Feng
Pages: 2642-2642
Published online on: 26 March 2020

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

Yihe Ma, Ye Chen, Yuhui Liang, Yun Huang, Miao Gong, Lifeng Tian, Xiaojun Xiao, Jingyan Liu, Qinmiao Huang
Article Number: 77
Published online on: 31 December 2025

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Article Open Access

Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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Expression of Concern Open Access

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Article Open Access

Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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Article Open Access

ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Article Open Access

Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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Article Open Access

CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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Expression of Concern Open Access

[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Article Open Access

Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Review Open Access

Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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Retraction Open Access

[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Review Open Access

Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Review Open Access

Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Review Open Access

Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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Retraction Open Access

[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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Article Open Access

ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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Correction Open Access

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Article Open Access

Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Article Open Access

Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Review Open Access

Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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Article Open Access

lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Review Open Access

Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Article Open Access

Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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