Open Access

Tumor‑associated macrophages in lung cancer: Friend or foe? (Review)

  • Authors:
    • Fei Xu
    • Ying Wei
    • Zhao Tang
    • Baojun Liu
    • Jingcheng Dong
  • View Affiliations

  • Published online on: September 17, 2020     https://doi.org/10.3892/mmr.2020.11518
  • Pages: 4107-4115
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Typically, tumor‑associated macrophages (TAMs), an abundant population of leukocytes in lung cancer, are affected by tumor microenvironment (TME) and shift towards either a pro‑tumor (M2‑like) or an anti‑tumor phenotype (M1‑like). M2‑polarized macrophages, are one of the primary tumor‑infiltrating immune cells and were reported to be associated with the promotion of cancer cell growth, invasion, metastasis, and angiogenesis. TAMs are considered a potential target for adjuvant anticancer therapies, and recent therapeutic approaches targeting the M2 polarization of TAMs have shown encouraging results. The present review discusses recent developments in the role of TAMs in cancer, in particular TAMs functions, clinical implication and prospective therapeutic strategies in lung cancer.
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November-2020
Volume 22 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Xu F, Wei Y, Tang Z, Liu B and Dong J: Tumor‑associated macrophages in lung cancer: Friend or foe? (Review). Mol Med Rep 22: 4107-4115, 2020
APA
Xu, F., Wei, Y., Tang, Z., Liu, B., & Dong, J. (2020). Tumor‑associated macrophages in lung cancer: Friend or foe? (Review). Molecular Medicine Reports, 22, 4107-4115. https://doi.org/10.3892/mmr.2020.11518
MLA
Xu, F., Wei, Y., Tang, Z., Liu, B., Dong, J."Tumor‑associated macrophages in lung cancer: Friend or foe? (Review)". Molecular Medicine Reports 22.5 (2020): 4107-4115.
Chicago
Xu, F., Wei, Y., Tang, Z., Liu, B., Dong, J."Tumor‑associated macrophages in lung cancer: Friend or foe? (Review)". Molecular Medicine Reports 22, no. 5 (2020): 4107-4115. https://doi.org/10.3892/mmr.2020.11518