Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2021 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Roles of telomeres and telomerase in age‑related renal diseases (Review)

  • Authors:
    • Haili Li
    • Boyuan Wang
    • Daoqun Li
    • Jinyuan Li
    • Ying Luo
    • Juhua Dan
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China, The Key Lab of Sports and Rehabilitation, Faculty of Physical Education, Yuxi Normal University, Yuxi, Yunnan 653100, P.R. China, Department of Human Anatomy, School of Basic Medicine and Institute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250014, P.R. China, Department of General Surgery, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
    |
    Published online on: November 27, 2020
       https://doi.org/10.3892/mmr.2020.11735
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Age‑related renal diseases, which account for various progressive renal disorders associated with cellular and organismal senescence, are becoming a substantial public health burden. However, their aetiologies are complicated and their pathogeneses remain poorly understood. Telomeres and telomerase are known to be essential for maintaining the integrity and stability of eukaryotic genomes and serve crucial roles in numerous related signalling pathways that activate renal functions, such as repair and regeneration. Previous studies have reported that telomere dysfunction served a role in various types of age‑related kidney disease through various different molecular pathways. The present review aimed to summarise the current knowledge of the association between telomeres and ageing‑related kidney diseases and explored the contribution of dysfunctional telomeres to these diseases. The findings may help to provide novel strategies for treating patients with renal disease.
View Figures

Figure 1

View References

1 

Shay JW and Wright WE: Hallmarks of telomeres in ageing research. J Pathol. 211:114–123. 2007. View Article : Google Scholar

2 

Pańczyszyn A, Boniewska-Bernacka E and Goc A: The role of telomeres and telomerase in the senescence of postmitotic cells. DNA Repair (Amst). 95:1029562020. View Article : Google Scholar

3 

Smith EM, Pendlebury DF and Nandakumar J: Structural biology of telomeres and telomerase. Cell Mol Life Sci. 77:61–79. 2020. View Article : Google Scholar

4 

Ameh OI, Okpechi IG, Dandara C and Kengne AP: Association between telomere length, chronic kidney disease, and renal traits: A systematic review. OMICS. 21:143–155. 2017. View Article : Google Scholar

5 

Bolignano D, Mattace-Raso F, Sijbrands EJ and Zoccali C: The aging kidney revisited: A systematic review. Ageing Res Rev. 14:65–80. 2014. View Article : Google Scholar

6 

Sitaram RT, Cairney CJ, Grabowski P, Keith WN, Hallberg B, Ljungberg B and Roos G: The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma. Int J Cancer. 125:783–790. 2009. View Article : Google Scholar

7 

Svenson U, Gronlund E, Soderstrom I, Sitaram RT, Ljungberg B and Roos G: Telomere length in relation to immunological parameters in patients with renal cell carcinoma. PLoS One. 8:e555432013. View Article : Google Scholar

8 

Melk A, Schmidt BM, Takeuchi O, Sawitzki B, Rayner DC and Halloran PF: Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int. 65:510–520. 2004. View Article : Google Scholar

9 

de Lange T: A loopy view of telomere evolution. Front Genet. 6:3212015. View Article : Google Scholar

10 

Wood AM, Laster K, Rice EL and Kosak ST: A beginning of the end: New insights into the functional organization of telomeres. Nucleus. 6:172–178. 2015. View Article : Google Scholar

11 

de Lange T: Protection of mammalian telomeres. Oncogene. 21:532–540. 2002. View Article : Google Scholar

12 

Nagpal N and Agarwal S: Telomerase RNA processing: Implications for human health and disease. Stem Cells. 2020.(Epub ahead of print). View Article : Google Scholar

13 

Serakinci N, Graakjaer J and Kolvraa S: Telomere stability and telomerase in mesenchymal stem cells. Biochimie. 90:33–40. 2008. View Article : Google Scholar

14 

Blagoev KB: Cell Proliferation in the presence of telomerase. PLoS One. 4:e26222009. View Article : Google Scholar

15 

Cong YS, Wright WE and Shay JW: Human telomerase and its regulation. Microbiol Mol Biol Rev. 66:407–425, table of contents. 2002. View Article : Google Scholar

16 

Buseman CM, Wright WE and Shay JW: Is telomerase a viable target in cancer? Mutat Res. 730:90–97. 2012. View Article : Google Scholar

17 

Melk A, Kittikowit W, Sandhu I, Halloran KM, Grimm P, Schmidt BMW and Halloran PF: Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int. 63:2134–2143. 2003. View Article : Google Scholar

18 

Li Y and Lerman LO: Cellular senescence: A new player in kidney injury. Hypertension. 76:1069–1075. 2020. View Article : Google Scholar

19 

Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L, Qureshi AR, Yuzawa Y, Matsuo S and Maruyama S: Telomere attrition and elongation after chronic dialysis initiation in patients with end-stage renal disease. Blood Purif. 41:25–33. 2016. View Article : Google Scholar

20 

Perico N, Remuzzi G and Benigni A: Aging and the kidney. Curr Opin Nephrol Hypertens. 20:312–317. 2011. View Article : Google Scholar

21 

Abdel-Rahman EM and Okusa MD: Effects of aging on renal function and regenerative capacity. Nephron Clin Pract. 127:15–20. 2014. View Article : Google Scholar

22 

Wills LP and Schnellmann RG: Telomeres and telomerase in renal health. J Am Soc Nephrol. 22:39–41. 2011. View Article : Google Scholar

23 

Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA and Greider CW: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:25–34. 1997. View Article : Google Scholar

24 

Wright WE and Shay JW: Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat Med. 6:849–851. 2000. View Article : Google Scholar

25 

Kloda K, Domanski L, Kwiatkowska E, Borowiecka E, Safranow K, Drozd A, Ciechanowicz A, Maciejewska-Karłowska A, Sawczuk M, Pawlik A and Ciechanowski K: hTERT, BICD1 and chromosome 18 polymorphisms associated with telomere length affect kidney allograft function after transplantation. Kidney Blood Press Res. 40:111–120. 2015. View Article : Google Scholar

26 

O'Hare AM, Bertenthal D, Walter LC, Garg AX, Covinsky K, Kaufman JS, Rodriguez RA and Allon M: When to refer patients with chronic kidney disease for vascular access surgery: Should age be a consideration? Kidney Int. 71:555–561. 2007. View Article : Google Scholar

27 

Verzola D, Gandolfo MT, Gaetani G, Ferraris A, Mangerini R, Ferrario F, Villaggio B, Gianiorio F, Tosetti F, Weiss U, et al: Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. Am J Physiol Renal Physiol. 295:F1563–F1573. 2008. View Article : Google Scholar

28 

Lindeman RD, Tobin J and Shock NW: Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 33:278–285. 1985. View Article : Google Scholar

29 

Chow WH, Dong LM and Devesa SS: Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 7:245–257. 2010. View Article : Google Scholar

30 

Klatte T, Rossi SH and Stewart GD: Prognostic factors and prognostic models for renal cell carcinoma: A literature review. World J Urol. 36:1943–1952. 2018. View Article : Google Scholar

31 

Morais M, Dias F, Teixeira AL and Medeiros R: Telomere length in renal cell carcinoma: The Jekyll and Hyde biomarker of ageing of the kidney. Cancer Manag Res. 12:1669–1679. 2020. View Article : Google Scholar

32 

Pal D, Sharma U, Singh SK, Kakkar N and Prasad R: Inhibition of hTERT expression by MAP kinase inhibitor induces cell death in renal cell carcinoma. Urol Oncol. 35:401–408. 2017. View Article : Google Scholar

33 

Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK and Spitz MR: Telomere dysfunction: A potential cancer predisposition factor. J Natl Cancer Inst. 95:1211–1218. 2003. View Article : Google Scholar

34 

Mehle C, Ljungberg B and Roos G: Telomere shortening in renal cell carcinoma. Cancer Res. 54:236–241. 1994.

35 

Gisselsson D, Gorunova L, Hoglund M, Mandahl N and Elfving P: Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas. Br J Cancer. 91:327–332. 2004. View Article : Google Scholar

36 

Carrozza F, Santoni M, Piva F, Cheng L, Lopez-Beltran A, Scarpelli M, Montironi R, Battelli N and Tamberi S: Emerging immunotherapeutic strategies targeting telomerases in genitourinary tumors. Crit Rev Oncol Hematol. 131:1–6. 2018. View Article : Google Scholar

37 

Svenson U, Ljungberg B and Roos G: Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma. Cancer Res. 69:2896–2901. 2009. View Article : Google Scholar

38 

Demanelis K, Jasmine F, Chen LS, Chernoff M, Tong L, Delgado D, Zhang C, Shinkle J, Sabarinathan M, Lin H, et al: Determinants of telomere length across human tissues. Science. 369:eaaz68762020. View Article : Google Scholar

39 

Aramburu T, Plucinsky S and Skordalakes E: POT1-TPP1 telomere length regulation and disease. Comput Struct Biotechnol J. 18:1939–1946. 2020. View Article : Google Scholar

40 

Pal D, Singh SK, Kakkar N and Prasad R: Expression of telomere binding proteins (RAP1 and POT1) in renal cell carcinoma and their correlation with clinicopathological parameters. Indian J Clin Biochem. 32:301–305. 2017. View Article : Google Scholar

41 

Dahse R, Fiedler W, Junker K, Schlichter A, Schubert J and Claussen U: Telomerase activity and telomere lengths: Alterations in renal cell carcinomas. Kidney Int. 56:1289–1290. 1999. View Article : Google Scholar

42 

Sugimura K, Yoshida N, Hisatomi H, Nakatani T and Ikemoto S: Telomerase activity in human renal cell carcinoma. BJU Int. 83:693–697. 1999. View Article : Google Scholar

43 

Tonelli M and Riella MC: Chronic kidney disease and the aging population. Kidney Int. 85:487–491. 2014. View Article : Google Scholar

44 

Kremers WK, Denic A, Lieske JC, Alexander MP, Kaushik V, Elsherbiny HE, Chakkera HA, Poggio ED and Rule AD: Distinguishing age-related from disease-related glomerulosclerosis on kidney biopsy: The aging kidney anatomy study. Nephrol Dial Transplant. 30:2034–2039. 2015. View Article : Google Scholar

45 

Nitta K, Okada K, Yanai M and Takahashi S: Aging and chronic kidney disease. Kidney Blood Press Res. 38:109–120. 2013. View Article : Google Scholar

46 

Cañadas-Garre M, Anderson K, Cappa R, Skelly R, Smyth LJ, McKnight AJ and Maxwell AP: Genetic susceptibility to chronic kidney disease-some more pieces for the heritability puzzle. Front Genet. 10:4532019. View Article : Google Scholar

47 

Tonelli M and Riella M: Chronic kidney disease and the aging population. J Cross Cult Gerontol. 29:231–237. 2014. View Article : Google Scholar

48 

Mazidi M, Rezaie P, Covic A, Malyszko J, Rysz J, Kengne AP and Banach M: Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States. Oncotarget. 8:80175–80181. 2017. View Article : Google Scholar

49 

Kidir V, Aynali A, Altuntas A, Inal S, Aridogan B and Sezer MT: Telomerase activity in patients with stage 2–5D chronic kidney disease. Nefrologia. 37:592–597. 2017.(In English and Spanish). View Article : Google Scholar

50 

Tsirpanlis G, Chatzipanagiotou S, Boufidou F, Kordinas V, Alevyzaki F, Zoga M, Kyritsis I, Stamatelou K, Triantafyllis G and Nicolaou C: Telomerase activity is decreased in peripheral blood mononuclear cells of hemodialysis patients. Am J Nephrol. 26:91–96. 2006. View Article : Google Scholar

51 

Sell DR and Monnier VM: End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen. J Clin Invest. 85:380–384. 1990. View Article : Google Scholar

52 

Wong LS, van der Harst P, de Boer RA, Codd V, Huzen J, Samani NJ, Hillege HL, Voors AA, van Gilst WH, Jaarsma T and van Veldhuisen DJ: Renal dysfunction is associated with shorter telomere length in heart failure. Clin Res Cardiol. 98:629–634. 2009. View Article : Google Scholar

53 

Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG, Shiels PG and Stenvinkel P: Inflammation and premature aging in advanced chronic kidney disease. Am J Physiol Renal Physiol. 313:F938–F950. 2017. View Article : Google Scholar

54 

Hu MC, Kuro-o M and Moe OW: Klotho and chronic kidney disease. Contrib Nephrol. 180:47–63. 2013. View Article : Google Scholar

55 

Vlassara H, Torreggiani M, Post JB, Zheng F, Uribarri J and Striker GE: Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging. Kidney Int Suppl. S3-11:2009.

56 

Wynn TA and Ramalingam TR: Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. Nat Med. 18:1028–1040. 2012. View Article : Google Scholar

57 

Rockey DC, Bell PD and Hill JA: Fibrosis-a common pathway to organ injury and failure. N Engl J Med. 372:1138–1149. 2015. View Article : Google Scholar

58 

Vaglio A, Salvarani C and Buzio C: Retroperitoneal fibrosis. Lancet. 367:241–251. 2006. View Article : Google Scholar

59 

Sziksz E, Pap D, Lippai R, Béres NJ, Fekete A, Szabó AJ and Vannay Á: Fibrosis related inflammatory mediators: Role of the IL-10 cytokine family. Mediators Inflamm. 2015:7646412015. View Article : Google Scholar

60 

Nowakowski ACH: Cystic fibrosis kidney disease: 10 Tips for clinicians. Front Med (Lausanne). 5:2422018. View Article : Google Scholar

61 

Piñeiro-Hermida S, Autilio C, Martínez P, Bosch F, Pérez-Gil J and Blasco MA: Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging. J Cell Biol. 219:e2020021202020. View Article : Google Scholar

62 

Sangaralingham SJ, Wang BH, Huang L, Kumfu S, Ichiki T, Krum H and Burnett JC Jr: Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen. Peptides. 76:108–114. 2016. View Article : Google Scholar

63 

Cianciolo RE, Benali SL and Aresu L: Aging in the canine kidney. Vet Pathol. 53:299–308. 2016. View Article : Google Scholar

64 

Naesens M: Replicative senescence in kidney aging, renal disease, and renal transplantation. Discov Med. 11:65–75. 2011.

65 

Turner KJ, Vasu V and Griffin DK: Telomere biology and human phenotype. Cells. 8:732019. View Article : Google Scholar

66 

Yang L, Besschetnova TY, Brooks CR, Shah JV and Bonventre JV: Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 16:535–543, 531p following 143. 2010. View Article : Google Scholar

67 

Ronco C, Bellomo R and Kellum JA: Acute kidney injury. Lancet. 394:1949–1964. 2019. View Article : Google Scholar

68 

Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA and Collins AJ: Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 20:223–228. 2009. View Article : Google Scholar

69 

Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L and Blackburn EH: Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun. 24:531–539. 2010. View Article : Google Scholar

70 

Kiecolt-Glaser JK and Glaser R: Psychological stress, telomeres, and telomerase. Brain Behav Immun. 24:529–530. 2010. View Article : Google Scholar

71 

Cheng H, Fan X, Lawson WE, Paueksakon P and Harris RC: Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy. Kidney Int. 88:85–94. 2015. View Article : Google Scholar

72 

Zhan M, Brooks C, Liu F, Sun L and Dong Z: Mitochondrial dynamics: Regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int. 83:568–581. 2013. View Article : Google Scholar

73 

Lane RK, Hilsabeck T and Rea SL: The role of mitochondrial dysfunction in age-related diseases. Biochim Biophys Acta. 1847:1387–1400. 2015. View Article : Google Scholar

74 

Volarevic V, Djokovic B, Jankovic MG, Harrell CR, Fellabaum C, Djonov V and Arsenijevic N: Molecular mechanisms of cisplatin-induced nephrotoxicity: A balance on the knife edge between renoprotection and tumor toxicity. J Biomed Sci. 26:252019. View Article : Google Scholar

75 

Shin YJ, Kim TH, Won AJ, Jung JY, Kwack SJ, Kacew S, Chung KH, Lee BM and Kim HS: Age-related differences in kidney injury biomarkers induced by cisplatin. Environ Toxicol Pharmacol. 37:1028–1039. 2014. View Article : Google Scholar

76 

Abdel-Kader K and Palevsky PM: Acute kidney injury in the elderly. Clin Geriatr Med. 25:331–358. 2009. View Article : Google Scholar

77 

Aubert G and Lansdorp PM: Telomeres and aging. Physiol Rev. 88:557–579. 2008. View Article : Google Scholar

78 

Westhoff JH, Schildhorn C, Jacobi C, Hömme M, Hartner A, Braun H, Kryzer C, Wang C, von Zglinicki T, Kränzlin B, et al: Telomere shortening reduces regenerative capacity after acute kidney injury. J Am Soc Nephrol. 21:327–336. 2010. View Article : Google Scholar

79 

Schmitt R and Cantley LG: The impact of aging on kidney repair. Am J Physiol Renal Physiol. 294:F1265–F1272. 2008. View Article : Google Scholar

80 

Andrade L, Rodrigues CE, Gomes SA and Noronha IL: Acute kidney injury as a condition of renal senescence. Cell Transplant. 27:739–753. 2018. View Article : Google Scholar

81 

Pei Y: Diagnostic approach in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 1:1108–1114. 2006. View Article : Google Scholar

82 

Mangolini A, de Stephanis L and Aguiari G: Role of calcium in polycystic kidney disease: From signaling to pathology. World J Nephrol. 5:76–83. 2016. View Article : Google Scholar

83 

Perumareddi P and Trelka DP: Autosomal dominant polycystic kidney disease. Prim Care. 47:673–689. 2020. View Article : Google Scholar

84 

McConnachie DJ, Stow JL and Mallett AJ: Ciliopathies and the kidney: A review. Am J Kidney Dis. Oct 8–2020.(Epub ahead of print). View Article : Google Scholar

85 

Rangan GK, Tchan MC, Tong A, Wong AT and Nankivell BJ: Recent advances in autosomal-dominant polycystic kidney disease. Intern Med J. 46:883–892. 2016. View Article : Google Scholar

86 

Iliuta IA, Kitchlu A and Pei Y: Methodological issues in clinical trials of polycystic kidney disease: A focused review. J Nephrol. 30:363–371. 2017. View Article : Google Scholar

87 

Yaghoubian A, de Virgilio C, White RA and Sarkisyan G: Increased incidence of renal cysts in patients with abdominal aortic aneurysms: A common pathogenesis? Ann Vasc Surg. 20:787–791. 2006. View Article : Google Scholar

88 

Kolatsi-Joannou M, Bingham C, Ellard S, Bulman MP, Allen LI, Hattersley AT and Woolf AS: Hepatocyte nuclear factor-1beta: A new kindred with renal cysts and diabetes and gene expression in normal human development. J Am Soc Nephrol. 12:2175–2180. 2001.

89 

Ta MH, Schwensen KG, Liuwantara D, Huso DL, Watnick T and Rangan GK: Constitutive renal Rel/nuclear factor-κB expression in lewis polycystic kidney disease rats. World J Nephrol. 5:339–357. 2016. View Article : Google Scholar

90 

Bergmann C, von Bothmer J, Ortiz Bruchle N, Venghaus A, Frank V, Fehrenbach H, Hampel T, Pape L, Buske A, Jonsson J, et al: Mutations in multiple PKD genes may explain early and severe polycystic kidney disease. J Am Soc Nephrol. 22:2047–2056. 2011. View Article : Google Scholar

91 

Hian CK, Lee CL and Thomas W: Renin-angiotensin-aldosterone system antagonism and polycystic kidney disease progression. Nephron. 134:59–63. 2016. View Article : Google Scholar

92 

Chapman AB: Autosomal dominant polycystic kidney disease: Time for a change? J Am Soc Nephrol. 18:1399–1407. 2007. View Article : Google Scholar

93 

Zhang W, Tan AY, Blumenfeld J, Liu G, Michaeel A, Zhang T, Robinson BD, Salvatore SP, Kapur S, Donahue S, et al: Papillary renal cell carcinoma with a somatic mutation in MET in a patient with autosomal dominant polycystic kidney disease. Cancer Genet. 209:11–20. 2016. View Article : Google Scholar

94 

Gansevoort RT, Arici M, Benzing T, Birn H, Capasso G, Covic A, Devuyst O, Drechsler C, Eckardt KU, Emma F, et al: Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: A position statement on behalf of the ERA-EDTA working groups on inherited kidney disorders and european renal best practice. Nephrol Dial Transplant. 31:337–348. 2016. View Article : Google Scholar

95 

Riwanto M, Kapoor S, Rodriguez D, Edenhofer I, Segerer S and Wuthrich RP: Inhibition of aerobic glycolysis attenuates disease progression in polycystic kidney disease. PLoS One. 11:e01466542016. View Article : Google Scholar

96 

Ta MH, Schwensen KG, Foster S, Korgaonkar M, Ozimek-Kulik JE, Phillips JK, Peduto A and Rangan GK: Effects of TORC1 inhibition during the early and established phases of polycystic kidney disease. PLoS One. 11:e01641932016. View Article : Google Scholar

97 

Couillard M, Guillaume R, Tanji N, D'Agati V and Trudel M: c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction. Cancer Res. 62:2210–2214. 2002.

98 

Raina R, Lou L, Berger B, Vogt B, Sao-Mai Do A, Cunningham R, Vasavada P, Herrmann K, Dell K and Simonson M: Relationship of urinary endothelin-1 with estimated glomerular filtration rate in autosomal dominant polycystic kidney disease: A pilot cross-sectional analysis. BMC Nephrol. 17:222016. View Article : Google Scholar

99 

Kocer D, Karakukcu C, Ozturk F, Eroglu E and Kocyigit I: Evaluation of fibrosis markers: Apelin and transforming growth factor-β1 in autosomal dominant polycystic kidney disease patients. Ther Apher Dial. 20:517–522. 2016. View Article : Google Scholar

100 

Martins DP, Souza MA, Baitello ME, Nogueira V, Oliveira CI, Pinhel MA, Caldas HC, Filho MA and Souza DR: Vascular endothelial growth factor as an angiogenesis biomarker for the progression of autosomal dominant polycystic kidney disease. Genet Mol Res. 15:2016. View Article : Google Scholar

101 

Peda JD, Salah SM, Wallace DP, Fields PE, Grantham CJ, Fields TA and Swenson-Fields KI: Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 9:1051–1061. 2016. View Article : Google Scholar

102 

de Melo AS, Dias SV, Cavalli Rde C, Cardoso VC, Bettiol H, Barbieri MA, Ferriani RA and Vieira CS: Pathogenesis of polycystic ovary syndrome: Multifactorial assessment from the foetal stage to menopause. Reproduction. 150:R11–R24. 2015. View Article : Google Scholar

103 

Borie R, Kannengiesser C, Dupin C, Debray MP, Cazes A and Crestani B: Impact of genetic factors on fibrosing interstitial lung diseases. Incidence and clinical presentation in adults. Presse Med. 49:1040242020. View Article : Google Scholar

104 

Ballew BJ and Savage SA: Updates on the biology and management of dyskeratosis congenita and related telomere biology disorders. Expert Rev Hematol. 6:327–337. 2013. View Article : Google Scholar

105 

Li H, Zhang Y, Dan J, Zhou R, Li C, Li R, Wu X, Singh SK, Chang JT, Yang J and Luo Y: p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis. Cancer Biol Med. 16:79–102. 2019. View Article : Google Scholar

106 

Duffy MJ, Synnott NC, O'Grady S and Crown J: Targeting p53 for the treatment of cancer. Semin Cancer Biol. Jul 30–2020.(Epub ahead of print). View Article : Google Scholar

107 

Sugarman ET, Zhang G and Shay JW: In perspective: An update on telomere targeting in cancer. Mol Carcinog. 58:1581–1588. 2019. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li H, Wang B, Li D, Li J, Luo Y and Dan J: Roles of telomeres and telomerase in age‑related renal diseases (Review). Mol Med Rep 23: 96, 2021.
APA
Li, H., Wang, B., Li, D., Li, J., Luo, Y., & Dan, J. (2021). Roles of telomeres and telomerase in age‑related renal diseases (Review). Molecular Medicine Reports, 23, 96. https://doi.org/10.3892/mmr.2020.11735
MLA
Li, H., Wang, B., Li, D., Li, J., Luo, Y., Dan, J."Roles of telomeres and telomerase in age‑related renal diseases (Review)". Molecular Medicine Reports 23.2 (2021): 96.
Chicago
Li, H., Wang, B., Li, D., Li, J., Luo, Y., Dan, J."Roles of telomeres and telomerase in age‑related renal diseases (Review)". Molecular Medicine Reports 23, no. 2 (2021): 96. https://doi.org/10.3892/mmr.2020.11735
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Wang B, Li D, Li J, Luo Y and Dan J: Roles of telomeres and telomerase in age‑related renal diseases (Review). Mol Med Rep 23: 96, 2021.
APA
Li, H., Wang, B., Li, D., Li, J., Luo, Y., & Dan, J. (2021). Roles of telomeres and telomerase in age‑related renal diseases (Review). Molecular Medicine Reports, 23, 96. https://doi.org/10.3892/mmr.2020.11735
MLA
Li, H., Wang, B., Li, D., Li, J., Luo, Y., Dan, J."Roles of telomeres and telomerase in age‑related renal diseases (Review)". Molecular Medicine Reports 23.2 (2021): 96.
Chicago
Li, H., Wang, B., Li, D., Li, J., Luo, Y., Dan, J."Roles of telomeres and telomerase in age‑related renal diseases (Review)". Molecular Medicine Reports 23, no. 2 (2021): 96. https://doi.org/10.3892/mmr.2020.11735
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team