Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species

  • Authors:
    • Yun Fu
    • Yuedian Ye
    • Guifang Zhu
    • Yangwei Xu
    • Jingbo Sun
    • Hongmei Wu
    • Feiyan Feng
    • Zhihui Wen
    • Shanshan Jiang
    • Yanyan Li
    • Qingling Zhang
  • View Affiliations

  • Published online on: December 23, 2020     https://doi.org/10.3892/mmr.2020.11809
  • Article Number: 170
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Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer‑related mortality worldwide according to Global Cancer Statistics 2018. Resveratrol (RSV) is a phenolic compound that possesses anticancer functions against various types of cancer, including breast and gastric cancer. However, the functions and mechanism underlying RSV in CRC are not completely understood. The present study aimed to investigate the anticancer effects and mechanism underlying RSV in CRC cells by conducting Cell Counting Kit‑8, apoptosis, reactive oxygen species (ROS) and western blotting assays. The results suggested that RSV dose‑dependently inhibited CRC cell viability, and increased cell apoptosis and ROS levels compared with the control group. The protein expression levels of Bax, cytochrome c, cleaved caspase‑9 and cleaved caspase‑3 were upregulated, whereas Bcl‑2 expression levels were downregulated in RSV‑treated CRC cells compared with control cells. The results indicated that RSV might activate the mitochondrial apoptotic pathway by increasing ROS release. The present study suggested that RSV possessed antitumour activity against CRC by modulating an ROS‑mediated mitochondrial apoptotic pathway.
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March-2021
Volume 23 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Fu Y, Ye Y, Zhu G, Xu Y, Sun J, Wu H, Feng F, Wen Z, Jiang S, Li Y, Li Y, et al: Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species. Mol Med Rep 23: 170, 2021
APA
Fu, Y., Ye, Y., Zhu, G., Xu, Y., Sun, J., Wu, H. ... Zhang, Q. (2021). Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species. Molecular Medicine Reports, 23, 170. https://doi.org/10.3892/mmr.2020.11809
MLA
Fu, Y., Ye, Y., Zhu, G., Xu, Y., Sun, J., Wu, H., Feng, F., Wen, Z., Jiang, S., Li, Y., Zhang, Q."Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species". Molecular Medicine Reports 23.3 (2021): 170.
Chicago
Fu, Y., Ye, Y., Zhu, G., Xu, Y., Sun, J., Wu, H., Feng, F., Wen, Z., Jiang, S., Li, Y., Zhang, Q."Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species". Molecular Medicine Reports 23, no. 3 (2021): 170. https://doi.org/10.3892/mmr.2020.11809